caa a22 4500 606177558 CHVBK 20210128100752.0 cr unu---uuuuu 210128e20150601xx s 000 0 eng 10.1007/s00018-015-1858-6 doi (NATIONALLICENCE)springer-10.1007/s00018-015-1858-6 Mononuclear phagocyte-mediated antifungal immunity: the role of chemotactic receptors and ligands [Elektronische Daten] [Muthulekha Swamydas, Timothy Break, Michail Lionakis] Over the past two decades, fungal infections have emerged as significant causes of morbidity and mortality in patients with hematological malignancies, hematopoietic stem cell or solid organ transplantation and acquired immunodeficiency syndrome. Besides neutrophils and CD4+ T lymphocytes, which have long been known to play an indispensable role in promoting protective antifungal immunity, mononuclear phagocytes are now being increasingly recognized as critical mediators of host defense against fungi. Thus, a recent surge of research studies has focused on understanding the mechanisms by which resident and recruited monocytes, macrophages and dendritic cells accumulate and become activated at the sites of fungal infection. Herein, we critically review how a variety of G-protein coupled chemoattractant receptors and their ligands mediate mononuclear phagocyte recruitment and effector function during infection by the most common human fungal pathogens. Springer Basel (outside the USA), 2015 Fungal infections nationallicence Monocytes nationallicence Macrophages nationallicence Dendritic cells nationallicence Chemotactic factors nationallicence Candidiasis nationallicence Aspergillosis nationallicence Cryptococcosis nationallicence AIDS : Acquired immunodeficiency syndrome nationallicence DCs : Dendritic cells nationallicence TNF : Tumor necrosis factor nationallicence GM-CSF : Granulocyte-macrophage colony-stimulating factor nationallicence C5aR : C5a receptor nationallicence LTB4R1 : Leukotriene B4 receptor 1 nationallicence FPR : Formyl-peptide receptor nationallicence PAFR : Platelet-activating factor receptor nationallicence NK : Natural killer nationallicence HSC : Hematopoietic stem cells nationallicence MPC : Myeloid progenitor cell nationallicence ART : Antiretroviral therapy nationallicence HIV : Human immunodeficiency virus nationallicence CNS : Central nervous system nationallicence 5-LO : 5-lipoxygenase nationallicence MMP : Matrix metalloproteinase nationallicence PCP : Pneumocystis pneumonia nationallicence Swamydas Muthulekha Fungal Pathogenesis Unit, Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institute of Health, 9000 Rockville Pike, Building 10, Room 11C102, 20892, Bethesda, MD, USA aut Break Timothy Fungal Pathogenesis Unit, Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institute of Health, 9000 Rockville Pike, Building 10, Room 11C102, 20892, Bethesda, MD, USA aut Lionakis Michail Fungal Pathogenesis Unit, Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institute of Health, 9000 Rockville Pike, Building 10, Room 11C102, 20892, Bethesda, MD, USA aut Cellular and Molecular Life Sciences Springer Basel 72/11(2015-06-01), 2157-2175 1420-682X 72:11<2157 2015 72 18 https://doi.org/10.1007/s00018-015-1858-6 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 review-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00018-015-1858-6 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Swamydas Muthulekha Fungal Pathogenesis Unit, Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institute of Health, 9000 Rockville Pike, Building 10, Room 11C102, 20892, Bethesda, MD, USA aut NATIONALLICENCE 700 1- Break Timothy Fungal Pathogenesis Unit, Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institute of Health, 9000 Rockville Pike, Building 10, Room 11C102, 20892, Bethesda, MD, USA aut NATIONALLICENCE 700 1- Lionakis Michail Fungal Pathogenesis Unit, Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institute of Health, 9000 Rockville Pike, Building 10, Room 11C102, 20892, Bethesda, MD, USA aut NATIONALLICENCE 773 0- Cellular and Molecular Life Sciences Springer Basel 72/11(2015-06-01), 2157-2175 1420-682X 72:11<2157 2015 72 18