caa a22 4500 606177574 CHVBK 20210128100752.0 cr unu---uuuuu 210128e20150601xx s 000 0 eng 10.1007/s00018-015-1848-8 doi (NATIONALLICENCE)springer-10.1007/s00018-015-1848-8 Na+-H+ exchanger-1 (NHE1) regulation in kidney proximal tubule [Elektronische Daten] [Mark Parker, Evan Myers, Jeffrey Schelling] The ubiquitously expressed plasma membrane Na+-H+ exchanger NHE1 is a 12 transmembrane-spanning protein that directs important cell functions such as homeostatic intracellular volume and pH control. The 315 amino acid cytosolic tail of NHE1 binds plasma membrane phospholipids and multiple proteins that regulate additional, ion-translocation independent functions. This review focuses on NHE1 structure/function relationships, as well as the role of NHE1 in kidney proximal tubule functions, including pH regulation, vectorial Na+ transport, cell volume control and cell survival. The implications of these functions are particularly critical in the setting of progressive, albuminuric kidney diseases, where the accumulation of reabsorbed fatty acids leads to disruption of NHE1-membrane phospholipid interactions and tubular atrophy, which is a poor prognostic factor for progression to end stage renal disease. This review amplifies the vital role of the proximal tubule NHE1 Na+-H+ exchanger as a kidney cell survival factor. Springer Basel, 2015 Na+-H+ exchange nationallicence Ion transport nationallicence Apoptosis nationallicence Cell survival nationallicence Tubular atrophy nationallicence Chronic kidney disease nationallicence AE2 : Anion exchange protein 2 nationallicence AKI : Acute kidney injury nationallicence CHP1 : Calcineurin-homologous protein 1 nationallicence CKD : Chronic kidney disease nationallicence ERM : Ezrin/radixin/moesin nationallicence ESRD : End stage renal disease nationallicence JAK2 : Janus kinase 2 nationallicence LC-CoA : Long chain fatty acyl-CoA nationallicence MDCK : Madin-Darby canine kidney cell line nationallicence NaPi-IIa : Na+-phosphate co-transporter nationallicence NBC : Na+/HCO3 − co-transporter nationallicence NCX1 : Na+-Ca2+ exchanger 1 nationallicence NHE : Na+-H+ exchanger nationallicence NIK : Nck (non-catalytic region of tyrosine kinase adaptor protein 1)-interacting kinase nationallicence NKCC1 : Na+/K+/Cl− co-transporter 1 nationallicence pHi : Intracellular pH nationallicence PI(4,5)P2 : Phosphatidylinositol 4,5-bisphosphate nationallicence ROCK1 : Rho-associated, coiled-coil-containing protein kinase 1 nationallicence RVI : Regulatory volume increase nationallicence SGK1 : Serum and glucocorticoid-regulated kinase 1 nationallicence SGLT : Sodium-glucose co-transporter nationallicence TM : Transmembrane-spanning domain nationallicence Parker Mark Department of Physiology and Biophysics, University at Buffalo: The State University of New York, 14214, Buffalo, NY, USA aut Myers Evan Department of Physiology and Biophysics, University at Buffalo: The State University of New York, 14214, Buffalo, NY, USA aut Schelling Jeffrey Department of Medicine, Case Western Reserve University, 44109, Cleveland, OH, USA aut Cellular and Molecular Life Sciences Springer Basel 72/11(2015-06-01), 2061-2074 1420-682X 72:11<2061 2015 72 18 https://doi.org/10.1007/s00018-015-1848-8 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 review-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00018-015-1848-8 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Parker Mark Department of Physiology and Biophysics, University at Buffalo: The State University of New York, 14214, Buffalo, NY, USA aut NATIONALLICENCE 700 1- Myers Evan Department of Physiology and Biophysics, University at Buffalo: The State University of New York, 14214, Buffalo, NY, USA aut NATIONALLICENCE 700 1- Schelling Jeffrey Department of Medicine, Case Western Reserve University, 44109, Cleveland, OH, USA aut NATIONALLICENCE 773 0- Cellular and Molecular Life Sciences Springer Basel 72/11(2015-06-01), 2061-2074 1420-682X 72:11<2061 2015 72 18