caa a22 4500 606177612 CHVBK 20210128100752.0 cr unu---uuuuu 210128e20150801xx s 000 0 eng 10.1007/s00018-015-1967-2 doi (NATIONALLICENCE)springer-10.1007/s00018-015-1967-2 Roles of connexins and pannexins in (neuro)endocrine physiology [Elektronische Daten] [David Hodson, Christian Legros, Michel Desarménien, Nathalie Guérineau] To ensure appropriate secretion in response to demand, (neuro)endocrine tissues liberate massive quantities of hormones, which act to coordinate and synchronize biological signals in distant secretory and nonsecretory cell populations. Intercellular communication plays a central role in this control. With regard to molecular identity, junctional cell-cell communication is supported by connexin-based gap junctions. In addition, connexin hemichannels, the structural precursors of gap junctions, as well as pannexin channels have recently emerged as possible modulators of the secretory process. This review focuses on the expression of connexins and pannexins in various (neuro)endocrine tissues, including the adrenal cortex and medulla, the anterior pituitary, the endocrine hypothalamus and the pineal, thyroid and parathyroid glands. Upon a physiological or pathological stimulus, junctional intercellular coupling can be acutely modulated or persistently remodeled, thus offering multiple regulatory possibilities. The functional roles of gap junction-mediated intercellular communication in endocrine physiology as well as the involvement of connexin/pannexin-related hemichannels are also discussed. Springer Basel, 2015 Connexin nationallicence Pannexin nationallicence Hemichannel nationallicence Endocrine nationallicence Adrenal gland nationallicence Pituitary gland nationallicence Endocrine hypothalamus nationallicence Pineal gland nationallicence Thyroid and parathyroid glands nationallicence ACTH : Adrenocorticotropic hormone nationallicence ATP : Adenosine triphosphate nationallicence ARC : Arcuate nationallicence cAMP : Cyclic adenosine monophosphate nationallicence CRH : Corticotropin-releasing hormone nationallicence Cx : Connexin nationallicence FS : Folliculostellate nationallicence FSH : Follicle-stimulating hormone nationallicence GH : Growth hormone nationallicence GHRH : Growth hormone-releasing hormone nationallicence GnRH : Gonadotropin-releasing hormone nationallicence LH : Luteinizing hormone nationallicence PACAP : Pituitary adenylate cyclase-activating peptide nationallicence Panx : Pannexin nationallicence PRL : Prolactin nationallicence PV : Parvocellular nationallicence PVN : Paraventricular nucleus nationallicence SON : Supraoptic nucleus nationallicence T3 : Triiodothyronine nationallicence T4 : Thyroxine nationallicence TRH : Thyrotropin-releasing hormone nationallicence TSH : Thyroid-stimulating hormone nationallicence ZF : Zona fasciculata nationallicence ZG : Zona glomerulosa nationallicence ZR : Zona reticularis nationallicence Hodson David Section of Cell Biology and Functional Genomics, Department of Medicine, Imperial College London, W12 0NN, London, UK aut Legros Christian Department of Integrated Neurovascular and Mitochondrial Biology, Angers, France aut Desarménien Michel CNRS, UMR5203, Institut de Génomique Fonctionnelle, 141 rue de la Cardonille, 34094, Montpellier Cedex 5, France aut Guérineau Nathalie CNRS, UMR5203, Institut de Génomique Fonctionnelle, 141 rue de la Cardonille, 34094, Montpellier Cedex 5, France aut Cellular and Molecular Life Sciences Springer Basel 72/15(2015-08-01), 2911-2928 1420-682X 72:15<2911 2015 72 18 https://doi.org/10.1007/s00018-015-1967-2 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 review-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00018-015-1967-2 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Hodson David Section of Cell Biology and Functional Genomics, Department of Medicine, Imperial College London, W12 0NN, London, UK aut NATIONALLICENCE 700 1- Legros Christian Department of Integrated Neurovascular and Mitochondrial Biology, Angers, France aut NATIONALLICENCE 700 1- Desarménien Michel CNRS, UMR5203, Institut de Génomique Fonctionnelle, 141 rue de la Cardonille, 34094, Montpellier Cedex 5, France aut NATIONALLICENCE 700 1- Guérineau Nathalie CNRS, UMR5203, Institut de Génomique Fonctionnelle, 141 rue de la Cardonille, 34094, Montpellier Cedex 5, France aut NATIONALLICENCE 773 0- Cellular and Molecular Life Sciences Springer Basel 72/15(2015-08-01), 2911-2928 1420-682X 72:15<2911 2015 72 18