caa a22 4500 606177647 CHVBK 20210128100753.0 cr unu---uuuuu 210128e20150801xx s 000 0 eng 10.1007/s00018-015-1969-0 doi (NATIONALLICENCE)springer-10.1007/s00018-015-1969-0 Connexins and pannexins in the integumentary system: the skin and appendages [Elektronische Daten] [Chrysovalantou Faniku, Catherine Wright, Patricia Martin] The integumentary system comprises the skin and its appendages, which includes hair, nails, feathers, sebaceous and eccrine glands. In this review, we focus on the expression profile of connexins and pannexins throughout the integumentary system in mammals, birds and fish. We provide a picture of the complexity of the connexin/pannexin network illustrating functional importance of these proteins in maintaining the integrity of the epidermal barrier. The differential regulation and expression of connexins and pannexins during skin renewal, together with a number of epidermal, hair and nail abnormalities associated with mutations in connexins, emphasize that the correct balance of connexin and pannexin expression is critical for maintenance of the skin and its appendages with both channel and non-channel functions playing profound roles. Changes in connexin expression during both hair and feather regeneration provide suggestions of specialized communication compartments. Finally, we discuss the potential use of zebrafish as a model for connexin skin biology, where evidence mounts that differential connexin expression is involved in skin patterning and pigmentation. Springer Basel, 2015 Skin nationallicence Hair nationallicence Feathers nationallicence Connexin nationallicence Pannexin nationallicence Zebrafish nationallicence ATP : Adenosine triphosphate nationallicence Cx : Connexin nationallicence ECM : Extracellular matrix nationallicence IRS : Inner root sheath nationallicence KO : Knockout nationallicence ODDD : Oculodentodigital dysplasia nationallicence ORS : Outer root sheath nationallicence Panx : Pannexin nationallicence Faniku Chrysovalantou Department of Life Sciences and Institute for Applied Health Research, Glasgow Caledonian University, G4 0BA, Glasgow, UK aut Wright Catherine Department of Life Sciences and Institute for Applied Health Research, Glasgow Caledonian University, G4 0BA, Glasgow, UK aut Martin Patricia Department of Life Sciences and Institute for Applied Health Research, Glasgow Caledonian University, G4 0BA, Glasgow, UK aut Cellular and Molecular Life Sciences Springer Basel 72/15(2015-08-01), 2937-2947 1420-682X 72:15<2937 2015 72 18 https://doi.org/10.1007/s00018-015-1969-0 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 review-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00018-015-1969-0 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Faniku Chrysovalantou Department of Life Sciences and Institute for Applied Health Research, Glasgow Caledonian University, G4 0BA, Glasgow, UK aut NATIONALLICENCE 700 1- Wright Catherine Department of Life Sciences and Institute for Applied Health Research, Glasgow Caledonian University, G4 0BA, Glasgow, UK aut NATIONALLICENCE 700 1- Martin Patricia Department of Life Sciences and Institute for Applied Health Research, Glasgow Caledonian University, G4 0BA, Glasgow, UK aut NATIONALLICENCE 773 0- Cellular and Molecular Life Sciences Springer Basel 72/15(2015-08-01), 2937-2947 1420-682X 72:15<2937 2015 72 18