caa a22 4500 606177655 CHVBK 20210128100753.0 cr unu---uuuuu 210128e20150801xx s 000 0 eng 10.1007/s00018-015-1965-4 doi (NATIONALLICENCE)springer-10.1007/s00018-015-1965-4 Physiological roles of connexins and pannexins in reproductive organs [Elektronische Daten] [Mark Kibschull, Alexandra Gellhaus, Diane Carette, Dominique Segretain, Georges Pointis, Jerome Gilleron] Reproductive organs are complex and well-structured tissues essential to perpetuate the species. In mammals, the male and female reproductive organs vary on their organization, morphology and function. Connectivity between cells in such tissues plays pivotal roles in organogenesis and tissue functions through the regulation of cellular proliferation, migration, differentiation and apoptosis. Connexins and pannexins can be seen as major regulators of these physiological processes. In the present review, we assembled several lines of evidence demonstrating that these two families of proteins are essential for male and female reproduction. Springer Basel, 2015 Connexin nationallicence Pannexin nationallicence Testis nationallicence Ovary nationallicence Function nationallicence ATP : Adenosine triphosphate nationallicence BTB : Blood-testis barrier nationallicence cAMP : Cyclic adenosine monophosphate nationallicence Cx(s) : Connexin(s) nationallicence EVT : Extravillous cytotrophoblast nationallicence FSH : Follicle-stimulating hormone nationallicence GJIC : Gap junctional intercellular communication nationallicence hCG : Human chorionic gonadotropin nationallicence LH : Luteinizing hormone nationallicence Panx(s) : Pannexin(s) nationallicence PGCs : Primordial germ cells nationallicence PTM : Peritubular myoid nationallicence ZO-1 : Zonula occludens 1 nationallicence Kibschull Mark Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, 25 Orde Street, M5T 3H7, Toronto, Canada aut Gellhaus Alexandra Department of Gynecology and Obstetrics, University of Duisburg-Essen, Hufelandstrasse 55, 45122, Essen, Germany aut Carette Diane UMR S1147, University Paris Descartes, 45 rue des Saints-Pères, 75006, Paris, France aut Segretain Dominique UMR S1147, University Paris Descartes, 45 rue des Saints-Pères, 75006, Paris, France aut Pointis Georges INSERM U 1065, University of Nice Sophia-Antipolis, 151 Route Saint-Antoine de Ginestière, BP 2 3194, 06204, Nice Cedex 3, France aut Gilleron Jerome INSERM U 1065, University of Nice Sophia-Antipolis, 151 Route Saint-Antoine de Ginestière, BP 2 3194, 06204, Nice Cedex 3, France aut Cellular and Molecular Life Sciences Springer Basel 72/15(2015-08-01), 2879-2898 1420-682X 72:15<2879 2015 72 18 https://doi.org/10.1007/s00018-015-1965-4 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 review-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00018-015-1965-4 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Kibschull Mark Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, 25 Orde Street, M5T 3H7, Toronto, Canada aut NATIONALLICENCE 700 1- Gellhaus Alexandra Department of Gynecology and Obstetrics, University of Duisburg-Essen, Hufelandstrasse 55, 45122, Essen, Germany aut NATIONALLICENCE 700 1- Carette Diane UMR S1147, University Paris Descartes, 45 rue des Saints-Pères, 75006, Paris, France aut NATIONALLICENCE 700 1- Segretain Dominique UMR S1147, University Paris Descartes, 45 rue des Saints-Pères, 75006, Paris, France aut NATIONALLICENCE 700 1- Pointis Georges INSERM U 1065, University of Nice Sophia-Antipolis, 151 Route Saint-Antoine de Ginestière, BP 2 3194, 06204, Nice Cedex 3, France aut NATIONALLICENCE 700 1- Gilleron Jerome INSERM U 1065, University of Nice Sophia-Antipolis, 151 Route Saint-Antoine de Ginestière, BP 2 3194, 06204, Nice Cedex 3, France aut NATIONALLICENCE 773 0- Cellular and Molecular Life Sciences Springer Basel 72/15(2015-08-01), 2879-2898 1420-682X 72:15<2879 2015 72 18