caa a22 4500 606177663 CHVBK 20210128100753.0 cr unu---uuuuu 210128e20150801xx s 000 0 eng 10.1007/s00018-015-1961-8 doi (NATIONALLICENCE)springer-10.1007/s00018-015-1961-8 Roles of connexins and pannexins in digestive homeostasis [Elektronische Daten] [Michaël Maes, Bruno Cogliati, Sara Crespo Yanguas, Joost Willebrords, Mathieu Vinken] Connexin proteins are abundantly present in the digestive system. They primarily form gap junctions, which control the intercellular exchange of critical homeostasis regulators. By doing so, gap junctions drive a plethora of gastrointestinal and hepatic functional features, including gastric and gut motility, gastric acid secretion, intestinal innate immune defense, xenobiotic biotransformation, glycogenolysis, bile secretion, ammonia detoxification and plasma protein synthesis. In the last decade, it has become clear that connexin hemichannels, which are the structural precursors of gap junctions, also provide a pathway for cellular communication, namely between the cytosol and the extracellular environment. Although merely pathological functions have been described, some physiological roles have been attributed to connexin hemichannels, in particular in the modulation of colonic motility. This equally holds true for cellular channels composed of pannexins, connexin-like proteins recently identified in the intestine and the liver, which have become acknowledged key players in inflammatory processes and that have been proposed to control colonic motility, secretion and blood flow. Springer Basel, 2015 Stomach nationallicence Intestine nationallicence Liver nationallicence Pannexin nationallicence Connexin nationallicence Physiology nationallicence ATP : Adenosine triphosphate nationallicence cAMP : Cyclic adenosine monophosphate nationallicence CL : Cytoplasmic loop nationallicence CT : Cytoplasmic carboxy tail nationallicence Cx : Connexin nationallicence EL : Extracellular loop nationallicence GJIC : Gap junctional intercellular communication nationallicence IP3 : Inositol triphosphate nationallicence NT : Cytoplasmic amino tail nationallicence Panx : Pannexin nationallicence TM : Transmembrane domain nationallicence Maes Michaël Department of In Vitro Toxicology and Dermato-Cosmetology, Vrije Universiteit Brussel, Laarbeeklaan 103, 1090, Brussels, Belgium aut Cogliati Bruno Department of Pathology, School of Veterinary Medicine and Animal Science, University of São Paulo, São Paulo, Brazil aut Crespo Yanguas Sara Department of In Vitro Toxicology and Dermato-Cosmetology, Vrije Universiteit Brussel, Laarbeeklaan 103, 1090, Brussels, Belgium aut Willebrords Joost Department of In Vitro Toxicology and Dermato-Cosmetology, Vrije Universiteit Brussel, Laarbeeklaan 103, 1090, Brussels, Belgium aut Vinken Mathieu Department of In Vitro Toxicology and Dermato-Cosmetology, Vrije Universiteit Brussel, Laarbeeklaan 103, 1090, Brussels, Belgium aut Cellular and Molecular Life Sciences Springer Basel 72/15(2015-08-01), 2809-2821 1420-682X 72:15<2809 2015 72 18 https://doi.org/10.1007/s00018-015-1961-8 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 review-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00018-015-1961-8 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Maes Michaël Department of In Vitro Toxicology and Dermato-Cosmetology, Vrije Universiteit Brussel, Laarbeeklaan 103, 1090, Brussels, Belgium aut NATIONALLICENCE 700 1- Cogliati Bruno Department of Pathology, School of Veterinary Medicine and Animal Science, University of São Paulo, São Paulo, Brazil aut NATIONALLICENCE 700 1- Crespo Yanguas Sara Department of In Vitro Toxicology and Dermato-Cosmetology, Vrije Universiteit Brussel, Laarbeeklaan 103, 1090, Brussels, Belgium aut NATIONALLICENCE 700 1- Willebrords Joost Department of In Vitro Toxicology and Dermato-Cosmetology, Vrije Universiteit Brussel, Laarbeeklaan 103, 1090, Brussels, Belgium aut NATIONALLICENCE 700 1- Vinken Mathieu Department of In Vitro Toxicology and Dermato-Cosmetology, Vrije Universiteit Brussel, Laarbeeklaan 103, 1090, Brussels, Belgium aut NATIONALLICENCE 773 0- Cellular and Molecular Life Sciences Springer Basel 72/15(2015-08-01), 2809-2821 1420-682X 72:15<2809 2015 72 18