caa a22 4500 606177698 CHVBK 20210128100753.0 cr unu---uuuuu 210128e20150801xx s 000 0 eng 10.1007/s00018-015-1966-3 doi (NATIONALLICENCE)springer-10.1007/s00018-015-1966-3 Connexins and pannexins in the immune system and lymphatic organs [Elektronische Daten] [Aaron Glass, Elizabeth Snyder, Steven Taffet] Connexin43 and pannexin1 are found in immune cells. While gap junctional communication has been demonstrated between immune cells, hemichannels have been implicated in many cellular functions. Among the functions involved as being connexin dependent and pannexin dependent are cell migration, phagocytosis, antigen presentation, T-cell reactivity and B-cell responses. Surprisingly, many of these connexin-related and pannexin-related functions are not recapitulated in in vivo models. This is leading to a reevaluation of the role of these proteins in immune function. Springer Basel, 2015 Connexin nationallicence Pannexin nationallicence Immunity nationallicence T-cell nationallicence Macrophage nationallicence Lymphatic nationallicence APC(s) : Antigen presenting cell(s) nationallicence ATP : Adenosine triphosphate nationallicence Cx : Connexin nationallicence (f)DC(s) : (Follicular) dendritic cell(s) nationallicence GFP : Green fluorescent protein nationallicence GJIC : Gap junctional intercellular communication nationallicence IFN-γ : Interferon-γ nationallicence LPS : Lipopolysaccharide nationallicence MHC : Major histocompatibility complex nationallicence Panx : Pannexin nationallicence TCR : T-cell receptor nationallicence Treg(s) : Regulatory T-cell(s) nationallicence Glass Aaron Department of Microbiology and Immunology, SUNY Upstate Medical University, 750 E Adams Street, 13210, Syracuse, NY, USA aut Snyder Elizabeth Department of Microbiology and Immunology, SUNY Upstate Medical University, 750 E Adams Street, 13210, Syracuse, NY, USA aut Taffet Steven Department of Microbiology and Immunology, SUNY Upstate Medical University, 750 E Adams Street, 13210, Syracuse, NY, USA aut Cellular and Molecular Life Sciences Springer Basel 72/15(2015-08-01), 2899-2910 1420-682X 72:15<2899 2015 72 18 https://doi.org/10.1007/s00018-015-1966-3 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 review-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00018-015-1966-3 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Glass Aaron Department of Microbiology and Immunology, SUNY Upstate Medical University, 750 E Adams Street, 13210, Syracuse, NY, USA aut NATIONALLICENCE 700 1- Snyder Elizabeth Department of Microbiology and Immunology, SUNY Upstate Medical University, 750 E Adams Street, 13210, Syracuse, NY, USA aut NATIONALLICENCE 700 1- Taffet Steven Department of Microbiology and Immunology, SUNY Upstate Medical University, 750 E Adams Street, 13210, Syracuse, NY, USA aut NATIONALLICENCE 773 0- Cellular and Molecular Life Sciences Springer Basel 72/15(2015-08-01), 2899-2910 1420-682X 72:15<2899 2015 72 18