caa a22 4500 60617771X CHVBK 20210128100753.0 cr unu---uuuuu 210128e20150801xx s 000 0 eng 10.1007/s00018-015-1964-5 doi (NATIONALLICENCE)springer-10.1007/s00018-015-1964-5 Functional roles of connexins and pannexins in the kidney [Elektronische Daten] [Ahmed Abed, Panagiotis Kavvadas, Christos Chadjichristos] Kidneys are highly complex organs, playing a crucial role in human physiopathology, as they are implicated in vital processes, such as fluid filtration and vasomotor tone regulation. There is growing evidence that gap junctions are major determinants of renal physiopathology. It has been demonstrated that their expression or channel activity may vary depending on physiological and pathological situations within distinct renal compartments. While some studies have focused on the role of connexins in renal physiology, our knowledge regarding the functional relevance of pannexins is still very limited. In this paper, we provide an overview of the involvement of connexins, pannexins and their channels in various physiological processes related to different renal compartments. Springer Basel, 2015 Connexin nationallicence Pannexin nationallicence Renal physiology nationallicence ATP : Adenosine triphosphate nationallicence Cx(s) : Connexin(s) nationallicence EDHF : Endothelium-derived hyperpolarizing factor nationallicence eNOS : Endothelial nitric oxide synthase nationallicence GJ(s) : Gap junction(s) nationallicence HC(s) : Hemichannel(s) nationallicence JGA : Juxtaglomerular apparatus nationallicence KO : Knock-out nationallicence MEJ(s) : Myoendothelial junction(s) nationallicence MR : Myogenic response nationallicence NO : Nitric oxide nationallicence Panx(s) : Pannexin(s) nationallicence TGF : Tubuloglomerular feedback nationallicence VSMC(s) : Vascular smooth muscle cell(s) nationallicence Abed Ahmed INSERM UMR-S1155, Batiment Recherche, Tenon Hospital, 4 rue de la Chine, 75020, Paris, France aut Kavvadas Panagiotis INSERM UMR-S1155, Batiment Recherche, Tenon Hospital, 4 rue de la Chine, 75020, Paris, France aut Chadjichristos Christos INSERM UMR-S1155, Batiment Recherche, Tenon Hospital, 4 rue de la Chine, 75020, Paris, France aut Cellular and Molecular Life Sciences Springer Basel 72/15(2015-08-01), 2869-2877 1420-682X 72:15<2869 2015 72 18 https://doi.org/10.1007/s00018-015-1964-5 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 review-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00018-015-1964-5 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Abed Ahmed INSERM UMR-S1155, Batiment Recherche, Tenon Hospital, 4 rue de la Chine, 75020, Paris, France aut NATIONALLICENCE 700 1- Kavvadas Panagiotis INSERM UMR-S1155, Batiment Recherche, Tenon Hospital, 4 rue de la Chine, 75020, Paris, France aut NATIONALLICENCE 700 1- Chadjichristos Christos INSERM UMR-S1155, Batiment Recherche, Tenon Hospital, 4 rue de la Chine, 75020, Paris, France aut NATIONALLICENCE 773 0- Cellular and Molecular Life Sciences Springer Basel 72/15(2015-08-01), 2869-2877 1420-682X 72:15<2869 2015 72 18