caa a22 4500 606177728 CHVBK 20210128100753.0 cr unu---uuuuu 210128e20150801xx s 000 0 eng 10.1007/s00018-015-1960-9 doi (NATIONALLICENCE)springer-10.1007/s00018-015-1960-9 The lung communication network [Elektronische Daten] [Davide Losa, Marc Chanson] The different types of cells in the lung, from the conducting airway epithelium to the alveolar epithelium and the pulmonary vasculature, are interconnected by gap junctions. The specific profile of gap junction proteins, the connexins, expressed in these different cell types forms compartments of intercellular communication that can be further shaped by the release of extracellular nucleotides via pannexin1 channels. In this review, we focus on the physiology of connexins and pannexins and describe how this lung communication network modulates lung function and host defenses in conductive and respiratory airways. Springer Basel, 2015 Lung nationallicence Intercellular communication nationallicence Connexin nationallicence Pannexin nationallicence Physiology nationallicence Disease nationallicence A2B : Adenosine 2B receptor nationallicence ANO1 : Anoctamin1 nationallicence ASL : Airway surface liquid nationallicence ATI : Alveolar type I cells nationallicence ATII : Alveolar type II cells nationallicence ATP : Adenosine triphosphate nationallicence BAL : Bronchoalveolar lavage nationallicence BMSC : Bone marrow-derived mesenchymal stem or stromal cells nationallicence C12 : N-3-oxo-dodecanoyl-l-homoserine lactone nationallicence CaCC : Calcium-activated chloride channels nationallicence CAMKK : Ca2+/calmodulin-dependent kinase kinase nationallicence cAMP : Cyclic adenosine monophosphate nationallicence CD73 : Ecto-5′-nucleotidase nationallicence CF : Cystic fibrosis nationallicence CFTR : Cystic fibrosis transmembrane conductance regulator nationallicence Cx(s) : Connexin(s) nationallicence ENaC : Amiloride-sensitive epithelial channel nationallicence FRAP : Fluorescence recovery after photobleaching nationallicence GJIC : Gap junctional intercellular communication nationallicence HPV : Hypoxic pulmonary vasoconstriction nationallicence IL-8 : Interleukin-8 nationallicence IP3 : Inositol triphosphate nationallicence JNK : c-Jun N-terminal kinases nationallicence LPS : Lipopolysaccharide nationallicence LXA4 : Lipoxin A4 nationallicence MAPK : Mitogen-activated protein kinase nationallicence MSC : Mesenchymal stem or stromal cell nationallicence NF-κB : Nuclear factor-κB nationallicence PAMP : Pathogen-associated molecular pattern nationallicence Panx(s) : Pannexin(s) nationallicence PGE2 : Prostaglandin E2 nationallicence P2R : Purinergic receptor nationallicence PRR : Pathogen recognition receptor nationallicence TLR : Toll-like receptor nationallicence TNF-α : Tumor necrosis factor-α nationallicence Losa Davide Geneva University Hospitals and University of Geneva, 1211 Geneva, Switzerland aut Chanson Marc Geneva University Hospitals and University of Geneva, 1211 Geneva, Switzerland aut Cellular and Molecular Life Sciences Springer Basel 72/15(2015-08-01), 2793-2808 1420-682X 72:15<2793 2015 72 18 https://doi.org/10.1007/s00018-015-1960-9 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 review-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00018-015-1960-9 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Losa Davide Geneva University Hospitals and University of Geneva, 1211 Geneva, Switzerland aut NATIONALLICENCE 700 1- Chanson Marc Geneva University Hospitals and University of Geneva, 1211 Geneva, Switzerland aut NATIONALLICENCE 773 0- Cellular and Molecular Life Sciences Springer Basel 72/15(2015-08-01), 2793-2808 1420-682X 72:15<2793 2015 72 18