caa a22 4500 606177744 CHVBK 20210128100753.0 cr unu---uuuuu 210128e20150101xx s 000 0 eng 10.1007/s11136-014-0648-1 doi (NATIONALLICENCE)springer-10.1007/s11136-014-0648-1 Assessment of score- and Rasch-based methods for group comparison of longitudinal patient-reported outcomes with intermittent missing data (informative and non-informative) [Elektronische Daten] [Élodie de Bock, Jean-Benoit Hardouin, Myriam Blanchin, Tanguy Le Neel, Gildas Kubis, Véronique Sébille] Purpose: The purpose of this study was to identify the most adequate strategy for group comparison of longitudinal patient-reported outcomes in the presence of possibly informative intermittent missing data. Models coming from classical test theory (CTT) and item response theory (IRT) were compared. Methods: Two groups of patients' responses to dichotomous items with three times of assessment were simulated. Different cases were considered: presence or absence of a group effect and/or a time effect, a total of 100 or 200 patients, 4 or 7 items and two different values for the correlation coefficient of the latent trait between two consecutive times (0.4 or 0.9). Cases including informative and non-informative intermittent missing data were compared at different rates (15, 30%). These simulated data were analyzed with CTT using score and mixed model (SM) and with IRT using longitudinal Rasch mixed model (LRM). The type I error, the power and the bias of the group effect estimations were compared between the two methods. Results: This study showed that LRM performs better than SM. When the rate of missing data rose to 30%, estimations were biased with SM mainly for informative missing data. Otherwise, LRM and SM methods were comparable concerning biases. However, regardless of the rate of intermittent missing data, power of LRM was higher compared to power of SM. Conclusions: In conclusion, LRM should be favored when the rate of missing data is higher than 15%. For other cases, SM and LRM provide similar results. Springer International Publishing Switzerland, 2014 IRT nationallicence CTT nationallicence Rasch models nationallicence Longitudinal data nationallicence PROs nationallicence Missing data nationallicence de Bock Élodie EA4275-SPHERE, ‘Biostatistics, Pharmacoepidemiology and Subjective Measures in Health Sciences', Faculté de Pharmacie, Université de Nantes, Pres Université Nantes Angers Le Mans, 1, rue Gaston Veil, 44035, Nantes Cedex 01, France aut Hardouin Jean-Benoit EA4275-SPHERE, ‘Biostatistics, Pharmacoepidemiology and Subjective Measures in Health Sciences', Faculté de Pharmacie, Université de Nantes, Pres Université Nantes Angers Le Mans, 1, rue Gaston Veil, 44035, Nantes Cedex 01, France aut Blanchin Myriam EA4275-SPHERE, ‘Biostatistics, Pharmacoepidemiology and Subjective Measures in Health Sciences', Faculté de Pharmacie, Université de Nantes, Pres Université Nantes Angers Le Mans, 1, rue Gaston Veil, 44035, Nantes Cedex 01, France aut Le Neel Tanguy EA4275-SPHERE, ‘Biostatistics, Pharmacoepidemiology and Subjective Measures in Health Sciences', Faculté de Pharmacie, Université de Nantes, Pres Université Nantes Angers Le Mans, 1, rue Gaston Veil, 44035, Nantes Cedex 01, France aut Kubis Gildas EA4275-SPHERE, ‘Biostatistics, Pharmacoepidemiology and Subjective Measures in Health Sciences', Faculté de Pharmacie, Université de Nantes, Pres Université Nantes Angers Le Mans, 1, rue Gaston Veil, 44035, Nantes Cedex 01, France aut Sébille Véronique EA4275-SPHERE, ‘Biostatistics, Pharmacoepidemiology and Subjective Measures in Health Sciences', Faculté de Pharmacie, Université de Nantes, Pres Université Nantes Angers Le Mans, 1, rue Gaston Veil, 44035, Nantes Cedex 01, France aut Quality of Life Research Springer International Publishing 24/1(2015-01-01), 19-29 0962-9343 24:1<19 2015 24 11136 https://doi.org/10.1007/s11136-014-0648-1 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s11136-014-0648-1 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- de Bock Élodie EA4275-SPHERE, ‘Biostatistics, Pharmacoepidemiology and Subjective Measures in Health Sciences', Faculté de Pharmacie, Université de Nantes, Pres Université Nantes Angers Le Mans, 1, rue Gaston Veil, 44035, Nantes Cedex 01, France aut NATIONALLICENCE 700 1- Hardouin Jean-Benoit EA4275-SPHERE, ‘Biostatistics, Pharmacoepidemiology and Subjective Measures in Health Sciences', Faculté de Pharmacie, Université de Nantes, Pres Université Nantes Angers Le Mans, 1, rue Gaston Veil, 44035, Nantes Cedex 01, France aut NATIONALLICENCE 700 1- Blanchin Myriam EA4275-SPHERE, ‘Biostatistics, Pharmacoepidemiology and Subjective Measures in Health Sciences', Faculté de Pharmacie, Université de Nantes, Pres Université Nantes Angers Le Mans, 1, rue Gaston Veil, 44035, Nantes Cedex 01, France aut NATIONALLICENCE 700 1- Le Neel Tanguy EA4275-SPHERE, ‘Biostatistics, Pharmacoepidemiology and Subjective Measures in Health Sciences', Faculté de Pharmacie, Université de Nantes, Pres Université Nantes Angers Le Mans, 1, rue Gaston Veil, 44035, Nantes Cedex 01, France aut NATIONALLICENCE 700 1- Kubis Gildas EA4275-SPHERE, ‘Biostatistics, Pharmacoepidemiology and Subjective Measures in Health Sciences', Faculté de Pharmacie, Université de Nantes, Pres Université Nantes Angers Le Mans, 1, rue Gaston Veil, 44035, Nantes Cedex 01, France aut NATIONALLICENCE 700 1- Sébille Véronique EA4275-SPHERE, ‘Biostatistics, Pharmacoepidemiology and Subjective Measures in Health Sciences', Faculté de Pharmacie, Université de Nantes, Pres Université Nantes Angers Le Mans, 1, rue Gaston Veil, 44035, Nantes Cedex 01, France aut NATIONALLICENCE 773 0- Quality of Life Research Springer International Publishing 24/1(2015-01-01), 19-29 0962-9343 24:1<19 2015 24 11136