caa a22 4500 606177795 CHVBK 20210128100753.0 cr unu---uuuuu 210128e20150101xx s 000 0 eng 10.1007/s11136-014-0799-0 doi (NATIONALLICENCE)springer-10.1007/s11136-014-0799-0 Testing the measurement invariance of the EORTC QLQ-C30 across primary cancer sites using multi-group confirmatory factor analysis [Elektronische Daten] [D. Costa, N. Aaronson, P. Fayers, J. Pallant, G. Velikova, M. King] Purpose: The EORTC Quality of Life Questionnaire is a widely used cancer-specific quality of life instrument comprising a core set of 30 items (QLQ-C30) supplemented by cancer site-specific modules. The purpose of this paper was to examine the extent to which the conventional multi-item domain structure of the QLQ-C30 holds across patients with seven different primary cancer sites. Methods: Multi-group confirmatory factor analysis was used to test whether a measurement model of the QLQ-C30 was invariant across cancer sites. Configural (same patterns of factor loadings), metric (equivalence of factor loadings) and scalar (equivalence of thresholds) invariance amongst the cancer site groups were assessed (N=1,906) by comparing the fit of a model with these parameters freely estimated to a model where estimates were constrained to be equal for the corresponding items in each group. Results: All groups exhibited good model fit except for the prostate group, which was excluded. Only 1 of 576 parameters was found to differ between primary sites: specifically, the first threshold of Item 1 in the breast cancer group exhibited non-invariance. In a post hoc analysis, several instances of non-invariance by treatment status (baseline, on-treatment, off-treatment) were observed. Conclusions: Given only one instance of non-invariance between cancer sites, there is a reason to be confident in the validity of conclusions drawn when comparing QLQ-C30 domain scores between different sites and when interpreting the scores of heterogeneous samples, although future research should assess the potential impact of confounding variables such as treatment and gender. Springer International Publishing Switzerland, 2014 EORTC QLQ-C30 nationallicence Measurement invariance nationallicence Quality of life nationallicence Multi-group confirmatory factor analysis nationallicence Costa D. Psycho-oncology Co-operative Research Group, University of Sydney, Chris O'Brien Lifehouse (C39Z), 2006, Sydney, NSW, Australia aut Aaronson N. Division of Psychosocial Research and Epidemiology, The Netherlands Cancer Institute, Amsterdam, The Netherlands aut Fayers P. Institute of Applied Health Sciences, University of Aberdeen, Aberdeen, UK aut Pallant J. Rural Health Academic Centre, University of Melbourne, Shepparton, VIC, Australia aut Velikova G. Leeds Institute for Cancer and Pathology, School of Medicine, University of Leeds and Leeds Cancer Centre, St James's Hospital, Leeds, UK aut King M. Psycho-oncology Co-operative Research Group, University of Sydney, Chris O'Brien Lifehouse (C39Z), 2006, Sydney, NSW, Australia aut Quality of Life Research Springer International Publishing 24/1(2015-01-01), 125-133 0962-9343 24:1<125 2015 24 11136 https://doi.org/10.1007/s11136-014-0799-0 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s11136-014-0799-0 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Costa D. Psycho-oncology Co-operative Research Group, University of Sydney, Chris O'Brien Lifehouse (C39Z), 2006, Sydney, NSW, Australia aut NATIONALLICENCE 700 1- Aaronson N. Division of Psychosocial Research and Epidemiology, The Netherlands Cancer Institute, Amsterdam, The Netherlands aut NATIONALLICENCE 700 1- Fayers P. Institute of Applied Health Sciences, University of Aberdeen, Aberdeen, UK aut NATIONALLICENCE 700 1- Pallant J. Rural Health Academic Centre, University of Melbourne, Shepparton, VIC, Australia aut NATIONALLICENCE 700 1- Velikova G. Leeds Institute for Cancer and Pathology, School of Medicine, University of Leeds and Leeds Cancer Centre, St James's Hospital, Leeds, UK aut NATIONALLICENCE 700 1- King M. Psycho-oncology Co-operative Research Group, University of Sydney, Chris O'Brien Lifehouse (C39Z), 2006, Sydney, NSW, Australia aut NATIONALLICENCE 773 0- Quality of Life Research Springer International Publishing 24/1(2015-01-01), 125-133 0962-9343 24:1<125 2015 24 11136