caa a22 4500 606177825 CHVBK 20210128100753.0 cr unu---uuuuu 210128e20150101xx s 000 0 eng 10.1007/s11136-014-0753-1 doi (NATIONALLICENCE)springer-10.1007/s11136-014-0753-1 Development and validation of a disease-targeted quality of life instrument for chronic diverticular disease: the DV-QOL [Elektronische Daten] [Brennan Spiegel, Mark Reid, Roger Bolus, Cynthia Whitman, Jennifer Talley, Stanley Dea, Kamyar Shahedi, Hetal Karsan, Chassidy Teal, Gil Melmed, Erica Cohen, Garth Fuller, Linnette Yen, Paul Hodgkins, M. Erder] Background: Colonic diverticular disease is typically conceived as acute diverticulitis attacks surrounded by periods of clinical silence. However, evolving data indicate that many patients have persistent symptoms and diminished health-related quality of life (HRQOL) long after acute attacks. We developed a disease-targeted HRQOL measure for symptomatic uncomplicated diverticular disease (SUDD)—the diverticulitis quality of life (DV-QOL) instrument. Methods: We conducted a systematic literature review to craft a conceptual model of SUDD HRQOL. This was complemented by three focus groups including 45 SUDD patients. We developed items based on our literature search, focus groups, and cognitive debriefings. We administered the items to SUDD patients with persistent symptoms following a confirmed diverticulitis event. We created scales based on factor analysis and evaluated the scales for reliability and validity. Results: Concept elicitation revealed a range of illness experiences attributed to SUDD. Coding of 20,490 transcribed words yielded a 52-code network with four primary, condition-related concepts: (1) physical symptoms (e.g., bloating); (2) behaviors (e.g., restrictions); (3) cognitions and concerns (e.g., fear); and (4) impact and consequences (e.g., absenteeism, anxiety). Based on patient language, we developed the 17-item DV-QOL instrument. In a cross-sectional validation sample of 197 patients, DV-QOL discriminated between patients with recent versus distant diverticulitis events and correlated highly with Short Form 36 and hospital anxiety and depression scores. Conclusions: Patients with SUDD attribute a wide range of negative psychological, social, and physical symptoms to their condition, both during and after acute attacks; DV-QOL captures these symptoms in a valid, reliable manner. Springer International Publishing Switzerland, 2014 Patient-reported outcomes nationallicence Health-related quality of life nationallicence Diverticulosis nationallicence Diverticulitis nationallicence Spiegel Brennan Department of Gastroenterology, VA Greater Los Angeles Healthcare System, 11301 Wilshire Blvd, Building 115, Room 215, 90073, Los Angeles, CA, USA aut Reid Mark Department of Gastroenterology, VA Greater Los Angeles Healthcare System, 11301 Wilshire Blvd, Building 115, Room 215, 90073, Los Angeles, CA, USA aut Bolus Roger Division of Digestive Diseases, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA aut Whitman Cynthia Cedars-Sinai Center for Outcomes Research and Education (CS-CORE), Los Angeles, CA, USA aut Talley Jennifer Department of Gastroenterology, VA Greater Los Angeles Healthcare System, 11301 Wilshire Blvd, Building 115, Room 215, 90073, Los Angeles, CA, USA aut Dea Stanley Department of Gastroenterology, UCLA-Olive View Medical Center, Los Angeles, CA, USA aut Shahedi Kamyar Department of Gastroenterology, UCLA-Olive View Medical Center, Los Angeles, CA, USA aut Karsan Hetal Atlanta Gastroenterology Associates, Atlanta, GA, USA aut Teal Chassidy Atlanta Gastroenterology Associates, Atlanta, GA, USA aut Melmed Gil Department of Gastroenterology, Cedars-Sinai Medical Center, Los Angeles, CA, USA aut Cohen Erica Department of Gastroenterology, VA Greater Los Angeles Healthcare System, 11301 Wilshire Blvd, Building 115, Room 215, 90073, Los Angeles, CA, USA aut Fuller Garth Department of Health Policy and Management, UCLA Fielding School of Public Health, Los Angeles, CA, USA aut Yen Linnette Shire Development LLC, Wayne, PA, USA aut Hodgkins Paul Shire Development LLC, Wayne, PA, USA aut Erder M. Shire Development LLC, Wayne, PA, USA aut Quality of Life Research Springer International Publishing 24/1(2015-01-01), 163-179 0962-9343 24:1<163 2015 24 11136 https://doi.org/10.1007/s11136-014-0753-1 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s11136-014-0753-1 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Spiegel Brennan Department of Gastroenterology, VA Greater Los Angeles Healthcare System, 11301 Wilshire Blvd, Building 115, Room 215, 90073, Los Angeles, CA, USA aut NATIONALLICENCE 700 1- Reid Mark Department of Gastroenterology, VA Greater Los Angeles Healthcare System, 11301 Wilshire Blvd, Building 115, Room 215, 90073, Los Angeles, CA, USA aut NATIONALLICENCE 700 1- Bolus Roger Division of Digestive Diseases, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA aut NATIONALLICENCE 700 1- Whitman Cynthia Cedars-Sinai Center for Outcomes Research and Education (CS-CORE), Los Angeles, CA, USA aut NATIONALLICENCE 700 1- Talley Jennifer Department of Gastroenterology, VA Greater Los Angeles Healthcare System, 11301 Wilshire Blvd, Building 115, Room 215, 90073, Los Angeles, CA, USA aut NATIONALLICENCE 700 1- Dea Stanley Department of Gastroenterology, UCLA-Olive View Medical Center, Los Angeles, CA, USA aut NATIONALLICENCE 700 1- Shahedi Kamyar Department of Gastroenterology, UCLA-Olive View Medical Center, Los Angeles, CA, USA aut NATIONALLICENCE 700 1- Karsan Hetal Atlanta Gastroenterology Associates, Atlanta, GA, USA aut NATIONALLICENCE 700 1- Teal Chassidy Atlanta Gastroenterology Associates, Atlanta, GA, USA aut NATIONALLICENCE 700 1- Melmed Gil Department of Gastroenterology, Cedars-Sinai Medical Center, Los Angeles, CA, USA aut NATIONALLICENCE 700 1- Cohen Erica Department of Gastroenterology, VA Greater Los Angeles Healthcare System, 11301 Wilshire Blvd, Building 115, Room 215, 90073, Los Angeles, CA, USA aut NATIONALLICENCE 700 1- Fuller Garth Department of Health Policy and Management, UCLA Fielding School of Public Health, Los Angeles, CA, USA aut NATIONALLICENCE 700 1- Yen Linnette Shire Development LLC, Wayne, PA, USA aut NATIONALLICENCE 700 1- Hodgkins Paul Shire Development LLC, Wayne, PA, USA aut NATIONALLICENCE 700 1- Erder M. Shire Development LLC, Wayne, PA, USA aut NATIONALLICENCE 773 0- Quality of Life Research Springer International Publishing 24/1(2015-01-01), 163-179 0962-9343 24:1<163 2015 24 11136