caa a22 4500 60617799X CHVBK 20210128100754.0 cr unu---uuuuu 210128e20150601xx s 000 0 eng 10.1007/s11136-014-0865-7 doi (NATIONALLICENCE)springer-10.1007/s11136-014-0865-7 Development of the Alcohol Quality of Life Scale (AQoLS): a new patient-reported outcome measure to assess health-related quality of life in alcohol use disorder [Elektronische Daten] [A. Luquiens, D. Whalley, S. Crawford, P. Laramée, L. Doward, M. Price, N. Hawken, J. Dorey, L. Owens, P. Llorca, B. Falissard, H. Aubin] Purpose: The development of patient-centred approaches and of reduction in consumption strategies in alcohol use disorder requires giving a larger place to qualitative assessments that are closer to patients' concerns and more clinically relevant than drinking outcomes and generic health-related quality of life instrument. Our purpose was to develop from patients input the Alcohol Quality of Life Scale (AQoLS), a disease-specific measure for alcohol use disorder (AUD). Methods: Concept elicitation focus groups were conducted with AUD patients in the UK and France. Thematic analysis was used to identify key areas of impact of AUD, and draft items were developed to capture these issues. The draft items underwent expert review to ensure clinical and cross-cultural applicability. Two iterative rounds of cognitive debriefing interviews were conducted with AUD patients in both countries, to assess face and content validity. Results: From focus groups conducted with 38 AUD patients, seven areas of impact emerged, forming the basis for the AQoLS: relationships, activities, looking after self, emotional impact, control, living conditions, and sleep. An initial pool of 90 items was reduced to 50 following the review process. In cognitive interviews, the measure took less than 10min to complete, and patients reported that items were relevant to their experience. Following Round 1 interviews (n=16), 14 items were removed because patients felt they were unclear or uneasy to respond to, 2 were combined, 7 were revised, and 4 new items were added. The recall period of 2weeks was changed to 4weeks, based on patient comments. Following Round 2 interviews (n=15), 5 items were removed and 3 were modified to produce the 34-item AQoLS. Conclusion: As the only de novo measure of health-related quality of life developed specifically for AUD, the AQoLS offers the potential of increased sensitivity to show the effectiveness of therapeutic interventions from the patient's perspective. Springer International Publishing Switzerland, 2014 Quality of life nationallicence Alcohol use disorder nationallicence Patient-reported outcome nationallicence Focus groups nationallicence Health-related quality of life nationallicence Luquiens A. Département de psychiatrie et d'addictologie, INSERM U669, Hôpital Paul Brousse, Univ Paris Sud, APHP, Villejuif, France aut Whalley D. RTI Health Solutions, The Pavilion, Towers Business Park, Wilmslow Road, Didsbury, M20 2LS, Manchester, UK aut Crawford S. RTI Health Solutions, The Pavilion, Towers Business Park, Wilmslow Road, Didsbury, M20 2LS, Manchester, UK aut Laramée P. Université Claude Bernard Lyon I, Villeurbanne, France aut Doward L. RTI Health Solutions, The Pavilion, Towers Business Park, Wilmslow Road, Didsbury, M20 2LS, Manchester, UK aut Price M. RTI Health Solutions, 3040 Cornwallis Road, Post Office Box 12194, 27709-2194, Research Triangle Park, NC, USA aut Hawken N. Creativ-Ceutical, 215, rue du Faubourg St-Honoré, 75008, Paris, France aut Dorey J. Creativ-Ceutical, 215, rue du Faubourg St-Honoré, 75008, Paris, France aut Owens L. Department of Molecular and Clinical Pharmacology, Institute of Translational Medicine, University of Liverpool, Liverpool, UK aut Llorca P. CMP B, CHU Clermont-Ferrand, EA U7280, Université d'Auvergne, Clermont-Ferrand, France aut Falissard B. Département de psychiatrie et d'addictologie, INSERM U669, Hôpital Paul Brousse, Univ Paris Sud, APHP, Villejuif, France aut Aubin H. Département de psychiatrie et d'addictologie, INSERM U669, Hôpital Paul Brousse, Univ Paris Sud, APHP, Villejuif, France aut Quality of Life Research Springer International Publishing 24/6(2015-06-01), 1471-1481 0962-9343 24:6<1471 2015 24 11136 https://doi.org/10.1007/s11136-014-0865-7 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s11136-014-0865-7 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Luquiens A. Département de psychiatrie et d'addictologie, INSERM U669, Hôpital Paul Brousse, Univ Paris Sud, APHP, Villejuif, France aut NATIONALLICENCE 700 1- Whalley D. RTI Health Solutions, The Pavilion, Towers Business Park, Wilmslow Road, Didsbury, M20 2LS, Manchester, UK aut NATIONALLICENCE 700 1- Crawford S. RTI Health Solutions, The Pavilion, Towers Business Park, Wilmslow Road, Didsbury, M20 2LS, Manchester, UK aut NATIONALLICENCE 700 1- Laramée P. Université Claude Bernard Lyon I, Villeurbanne, France aut NATIONALLICENCE 700 1- Doward L. RTI Health Solutions, The Pavilion, Towers Business Park, Wilmslow Road, Didsbury, M20 2LS, Manchester, UK aut NATIONALLICENCE 700 1- Price M. RTI Health Solutions, 3040 Cornwallis Road, Post Office Box 12194, 27709-2194, Research Triangle Park, NC, USA aut NATIONALLICENCE 700 1- Hawken N. Creativ-Ceutical, 215, rue du Faubourg St-Honoré, 75008, Paris, France aut NATIONALLICENCE 700 1- Dorey J. Creativ-Ceutical, 215, rue du Faubourg St-Honoré, 75008, Paris, France aut NATIONALLICENCE 700 1- Owens L. Department of Molecular and Clinical Pharmacology, Institute of Translational Medicine, University of Liverpool, Liverpool, UK aut NATIONALLICENCE 700 1- Llorca P. CMP B, CHU Clermont-Ferrand, EA U7280, Université d'Auvergne, Clermont-Ferrand, France aut NATIONALLICENCE 700 1- Falissard B. Département de psychiatrie et d'addictologie, INSERM U669, Hôpital Paul Brousse, Univ Paris Sud, APHP, Villejuif, France aut NATIONALLICENCE 700 1- Aubin H. Département de psychiatrie et d'addictologie, INSERM U669, Hôpital Paul Brousse, Univ Paris Sud, APHP, Villejuif, France aut NATIONALLICENCE 773 0- Quality of Life Research Springer International Publishing 24/6(2015-06-01), 1471-1481 0962-9343 24:6<1471 2015 24 11136