caa a22 4500 606178066 CHVBK 20210128100754.0 cr unu---uuuuu 210128e20150601xx s 000 0 eng 10.1007/s11136-014-0873-7 doi (NATIONALLICENCE)springer-10.1007/s11136-014-0873-7 Comparing responsiveness of the EQ-5D-5L, EQ-5D-3L and EQ VAS in stroke patients [Elektronische Daten] [Dominik Golicki, Maciej Niewada, Anna Karlińska, Julia Buczek, Adam Kobayashi, M. Janssen, A. Pickard] Aims: To date, evidence to support the construct validity of the EQ-5D-5L has primarily focused on cross-sectional data. The aims of this study were to examine the responsiveness of EQ-5D-5L in patients with stroke and to compare it with responsiveness of EQ-5D-3L and visual analogue scale (EQ VAS). Methods: We performed an observational longitudinal cohort study of patients with stroke. At 1week and 4months post-stroke, patients were assessed with modified Rankin Scale (mRS) and Barthel Index (BI)and were administered the EQ-5D-5L and EQ-5D-3L, including the EQ VAS. The EQ-5D-5L index scores were derived using the crosswalk methodology developed by the EuroQol Group. We classified patients according to two external criteria, based on mRS or BI, into 3 categories: ‘improvement,' ‘stable' or ‘deterioration'. We assessed the responsiveness of each measure in each patient subgroup using: effect size (ES), standardized response mean (SRM), F-statistic, relative efficiency and area under the receiver operating characteristic curve. Results: A total of 112 patients (52% females; mean age 70.6years; 93% ischemic stroke) completed all the instruments at both occasions. In subjects with clinical improvement, EQ-5D-5L was consistently responsive, showing moderate ES (0.51-0.71) and moderate to large SRM (0.69-0.86). In general, EQ-5D-3L index appeared to be more responsive (ES 0.63-0.82; SRM 0.77-1.06) and EQ VAS less responsive (ES 0.51-0.65; SRM 0.59-0.69) than EQ-5D-5L index. Conclusions: The EQ-5D-5L index, based on the crosswalk value set, seems to be appropriately responsive in patients with stroke, 4months after disease onset. As far as EQ-5D-5L index is scored according to crosswalk approach, the EQ-5D-3L index appears to be more responsive in stroke population. The Author(s), 2014 EQ-5D-5L nationallicence EQ-5D-3L nationallicence Health-related quality of life nationallicence Patient-reported outcomes nationallicence Psychometrics nationallicence Stroke nationallicence Golicki Dominik Department of Experimental and Clinical Pharmacology, Medical University of Warsaw, Banacha 1B St., 02-097, Warsaw, Poland aut Niewada Maciej Department of Experimental and Clinical Pharmacology, Medical University of Warsaw, Banacha 1B St., 02-097, Warsaw, Poland aut Karlińska Anna 2nd Department of Neurology, Institute of Psychiatry and Neurology, Jana III Sobieskiego 9 St, 02-957, Warsaw, Poland aut Buczek Julia 2nd Department of Neurology, Institute of Psychiatry and Neurology, Jana III Sobieskiego 9 St, 02-957, Warsaw, Poland aut Kobayashi Adam 2nd Department of Neurology, Institute of Psychiatry and Neurology, Jana III Sobieskiego 9 St, 02-957, Warsaw, Poland aut Janssen M. Department of Medical Psychology and Psychotherapy, Erasmus MC, Erasmus University, PO Box 2040, 3000, Rotterdam, CA, The Netherlands aut Pickard A. Department of Pharmacy Systems, Outcomes, and Policy, College of Pharmacy, University of Illinois at Chicago, 833 South Wood St, MC886, Chicago, IL, USA aut Quality of Life Research Springer International Publishing 24/6(2015-06-01), 1555-1563 0962-9343 24:6<1555 2015 24 11136 https://doi.org/10.1007/s11136-014-0873-7 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s11136-014-0873-7 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Golicki Dominik Department of Experimental and Clinical Pharmacology, Medical University of Warsaw, Banacha 1B St., 02-097, Warsaw, Poland aut NATIONALLICENCE 700 1- Niewada Maciej Department of Experimental and Clinical Pharmacology, Medical University of Warsaw, Banacha 1B St., 02-097, Warsaw, Poland aut NATIONALLICENCE 700 1- Karlińska Anna 2nd Department of Neurology, Institute of Psychiatry and Neurology, Jana III Sobieskiego 9 St, 02-957, Warsaw, Poland aut NATIONALLICENCE 700 1- Buczek Julia 2nd Department of Neurology, Institute of Psychiatry and Neurology, Jana III Sobieskiego 9 St, 02-957, Warsaw, Poland aut NATIONALLICENCE 700 1- Kobayashi Adam 2nd Department of Neurology, Institute of Psychiatry and Neurology, Jana III Sobieskiego 9 St, 02-957, Warsaw, Poland aut NATIONALLICENCE 700 1- Janssen M. Department of Medical Psychology and Psychotherapy, Erasmus MC, Erasmus University, PO Box 2040, 3000, Rotterdam, CA, The Netherlands aut NATIONALLICENCE 700 1- Pickard A. Department of Pharmacy Systems, Outcomes, and Policy, College of Pharmacy, University of Illinois at Chicago, 833 South Wood St, MC886, Chicago, IL, USA aut NATIONALLICENCE 773 0- Quality of Life Research Springer International Publishing 24/6(2015-06-01), 1555-1563 0962-9343 24:6<1555 2015 24 11136