caa a22 4500 606178090 CHVBK 20210128100755.0 cr unu---uuuuu 210128e20150601xx s 000 0 eng 10.1007/s11136-014-0855-9 doi (NATIONALLICENCE)springer-10.1007/s11136-014-0855-9 Strategies to improve success of pediatric cancer cooperative group quality of life studies: a report from the Children's Oncology Group [Elektronische Daten] [Puja Whitlow, Mae Caparas, Patricia Cullen, Christine Trask, Fiona Schulte, Leanne Embry, Rajaram Nagarajan, Donna Johnston, Lillian Sung] Purpose: Quality of life (QoL) has been increasingly emphasized in National Cancer Institute (NCI)-sponsored multisite clinical trials. Little is known about the outcomes of these trials in pediatric cancer. Objectives were to describe the proportion of Children's Oncology Group (COG) QoL studies that successfully accrued subjects and were analyzed, presented or published. Methods: We conducted a survey to describe outcomes of COG QoL studies. We included studies that contained at least one QoL assessment and were closed to patient accrual at the time of survey dissemination. Respondents were the investigators most responsible for the QoL aim. Results: Sixteen studies were included; response rate was 100%. Nine (56%) studies were embedded into a cancer treatment trial. Only 3 (19%) studies accrued their intended sample size. Seven (44%) studies were analyzed, 9 (56%) were presented, and 6 (38%) were published. Conclusions: NCI-sponsored pediatric QoL studies have high rates of failure to accrue. Many were not analyzed or disseminated. Using these data, strategies have been implemented to improve conduct in future trials. Monitoring of QoL studies is important to maximize the chances of study success. Springer International Publishing Switzerland, 2014 Quality of life nationallicence Pediatric cancer nationallicence Supportive care nationallicence Multicenter clinical trials nationallicence Whitlow Puja Division of Oncology, Cincinnati Children's Hospital Medical Center, 3333 Burnet Ave ML 7015, 45229, Cincinnati, OH, USA aut Caparas Mae Children's Oncology Group, Monrovia, CA, USA aut Cullen Patricia Division of Nursing, Loretto Heights School of Nursing, Regis University, Denver, CO, USA aut Trask Christine Neuropsychology Program, Department of Psychiatry, Rhode Island Hospital, Providence, RI, USA aut Schulte Fiona Departments of Oncology and Paediatrics, Alberta Children's Hospital Research Institute, and Haematology, Oncology and Transplant Program, Alberta Children's, University of Calgary, Calgary, AB, Canada aut Embry Leanne Department of Pediatrics, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA aut Nagarajan Rajaram Division of Oncology, Cincinnati Children's Hospital Medical Center, 3333 Burnet Ave ML 7015, 45229, Cincinnati, OH, USA aut Johnston Donna Division of Haematology/Oncology, Children's Hospital of Eastern Ontario, Ottawa, ON, Canada aut Sung Lillian Division of Haematology/Oncology, The Hospital for Sick Children, Toronto, ON, Canada aut Quality of Life Research Springer International Publishing 24/6(2015-06-01), 1297-1301 0962-9343 24:6<1297 2015 24 11136 https://doi.org/10.1007/s11136-014-0855-9 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s11136-014-0855-9 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Whitlow Puja Division of Oncology, Cincinnati Children's Hospital Medical Center, 3333 Burnet Ave ML 7015, 45229, Cincinnati, OH, USA aut NATIONALLICENCE 700 1- Caparas Mae Children's Oncology Group, Monrovia, CA, USA aut NATIONALLICENCE 700 1- Cullen Patricia Division of Nursing, Loretto Heights School of Nursing, Regis University, Denver, CO, USA aut NATIONALLICENCE 700 1- Trask Christine Neuropsychology Program, Department of Psychiatry, Rhode Island Hospital, Providence, RI, USA aut NATIONALLICENCE 700 1- Schulte Fiona Departments of Oncology and Paediatrics, Alberta Children's Hospital Research Institute, and Haematology, Oncology and Transplant Program, Alberta Children's, University of Calgary, Calgary, AB, Canada aut NATIONALLICENCE 700 1- Embry Leanne Department of Pediatrics, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA aut NATIONALLICENCE 700 1- Nagarajan Rajaram Division of Oncology, Cincinnati Children's Hospital Medical Center, 3333 Burnet Ave ML 7015, 45229, Cincinnati, OH, USA aut NATIONALLICENCE 700 1- Johnston Donna Division of Haematology/Oncology, Children's Hospital of Eastern Ontario, Ottawa, ON, Canada aut NATIONALLICENCE 700 1- Sung Lillian Division of Haematology/Oncology, The Hospital for Sick Children, Toronto, ON, Canada aut NATIONALLICENCE 773 0- Quality of Life Research Springer International Publishing 24/6(2015-06-01), 1297-1301 0962-9343 24:6<1297 2015 24 11136