caa a22 4500 606178236 CHVBK 20210128100755.0 cr unu---uuuuu 210128e20150601xx s 000 0 eng 10.1007/s11136-014-0858-6 doi (NATIONALLICENCE)springer-10.1007/s11136-014-0858-6 The impact of tuberculosis on health utility: a longitudinal cohort study [Elektronische Daten] [Melissa Bauer, Sara Ahmed, Andrea Benedetti, Christina Greenaway, Marek Lalli, Allison Leavens, Dick Menzies, Claudia Vadeboncoeur, Bilkis Vissandjée, Ashley Wynne, Kevin Schwartzman] Purpose: To estimate health utility derived from the Short Form-36 (SF-36) questionnaire and Standard Gamble instrument for persons diagnosed and treated for tuberculosis (TB) disease, those diagnosed and treated for latent TB infection (LTBI), and those screened but not treated for TB disease or LTBI over the year following their diagnosis/initial assessment. Methods: Participants were recruited at two Montreal hospitals (2008-2011) and completed the SF-36 and Standard Gamble at baseline and at follow-up visits 1, 2, 4, 6, 9, and 12months thereafter. SF-6D health utility scores were derived from SF-36 responses. Linear mixed models were used to compare mean health utility at each evaluation and changes in health utility between participants treated for TB disease, those treated for LTBI, and those in the control group. Results: Of the 263 participants, 48 were treated for TB disease, 105 for LTBI, and 110 were control participants. Fifty-four percent were women, mean age was 35years, and 90% were foreign-born. Participants treated for TB disease reported worse health utility compared with control participants at the baseline visit (mean SF-6D: 0.69 vs. 0.81; mean Standard Gamble: 0.64 vs. 0.96). They reported successive improvement at months 1 and 2 that was then sustained throughout follow-up. Health utility reported by participants treated for LTBI and control participants was comparable throughout the study. Conclusion: Treatment for TB disease had a substantial negative impact on health utility, particularly during the first 2months of treatment. However, treatment for LTBI did not have a substantial impact. Springer International Publishing Switzerland, 2014 Tuberculosis nationallicence Health utility nationallicence SF-6D nationallicence Standard Gamble nationallicence Linear mixed model regression nationallicence Bauer Melissa Respiratory Epidemiology and Clinical Research Unit, McGill University, Montreal, Canada aut Ahmed Sara Division of Clinical Epidemiology, McGill University Health Center, Montreal, Canada aut Benedetti Andrea Respiratory Epidemiology and Clinical Research Unit, McGill University, Montreal, Canada aut Greenaway Christina Division of Infectious Diseases and Clinical Epidemiology, Sir Mortimer B. Davis - Jewish General Hospital, Montreal, Canada aut Lalli Marek Respiratory Epidemiology and Clinical Research Unit, McGill University, Montreal, Canada aut Leavens Allison Respiratory Epidemiology and Clinical Research Unit, McGill University, Montreal, Canada aut Menzies Dick Respiratory Epidemiology and Clinical Research Unit, McGill University, Montreal, Canada aut Vadeboncoeur Claudia Respiratory Epidemiology and Clinical Research Unit, McGill University, Montreal, Canada aut Vissandjée Bilkis Faculté des sciences infirmières - School of Nursing, Université de Montréal, Montreal, Canada aut Wynne Ashley Respiratory Epidemiology and Clinical Research Unit, McGill University, Montreal, Canada aut Schwartzman Kevin Respiratory Epidemiology and Clinical Research Unit, McGill University, Montreal, Canada aut Quality of Life Research Springer International Publishing 24/6(2015-06-01), 1337-1349 0962-9343 24:6<1337 2015 24 11136 https://doi.org/10.1007/s11136-014-0858-6 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s11136-014-0858-6 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Bauer Melissa Respiratory Epidemiology and Clinical Research Unit, McGill University, Montreal, Canada aut NATIONALLICENCE 700 1- Ahmed Sara Division of Clinical Epidemiology, McGill University Health Center, Montreal, Canada aut NATIONALLICENCE 700 1- Benedetti Andrea Respiratory Epidemiology and Clinical Research Unit, McGill University, Montreal, Canada aut NATIONALLICENCE 700 1- Greenaway Christina Division of Infectious Diseases and Clinical Epidemiology, Sir Mortimer B. Davis - Jewish General Hospital, Montreal, Canada aut NATIONALLICENCE 700 1- Lalli Marek Respiratory Epidemiology and Clinical Research Unit, McGill University, Montreal, Canada aut NATIONALLICENCE 700 1- Leavens Allison Respiratory Epidemiology and Clinical Research Unit, McGill University, Montreal, Canada aut NATIONALLICENCE 700 1- Menzies Dick Respiratory Epidemiology and Clinical Research Unit, McGill University, Montreal, Canada aut NATIONALLICENCE 700 1- Vadeboncoeur Claudia Respiratory Epidemiology and Clinical Research Unit, McGill University, Montreal, Canada aut NATIONALLICENCE 700 1- Vissandjée Bilkis Faculté des sciences infirmières - School of Nursing, Université de Montréal, Montreal, Canada aut NATIONALLICENCE 700 1- Wynne Ashley Respiratory Epidemiology and Clinical Research Unit, McGill University, Montreal, Canada aut NATIONALLICENCE 700 1- Schwartzman Kevin Respiratory Epidemiology and Clinical Research Unit, McGill University, Montreal, Canada aut NATIONALLICENCE 773 0- Quality of Life Research Springer International Publishing 24/6(2015-06-01), 1337-1349 0962-9343 24:6<1337 2015 24 11136