caa a22 4500 606178260 CHVBK 20210128100755.0 cr unu---uuuuu 210128e20150901xx s 000 0 eng 10.1007/s11136-015-0952-4 doi (NATIONALLICENCE)springer-10.1007/s11136-015-0952-4 Quality of life and patient preferences: identification of subgroups of multiple sclerosis patients [Elektronische Daten] [Rosalba Rosato, Silvia Testa, Alessandra Oggero, Giorgia Molinengo, Antonio Bertolotto] Purpose: The aim of this study was to estimate preferences related to quality of life attributes in people with multiple sclerosis, by keeping heterogeneity of patient preference in mind, using the latent class approach. Methods: A discrete choice experiment survey was developed using the following attributes: activities of daily living, instrumental activities of daily living, pain/fatigue, anxiety/depression and attention/concentration. Choice sets were presented as pairs of hypothetical health status, based upon a fractional factorial design. Results: The latent class logit model estimated on 152 patients identified three subpopulations, which, respectively, attached more importance to: (1) the physical dimension; (2) pain/fatigue and anxiety/depression; and (3) instrumental activities of daily living impairments, anxiety/depression and attention/concentration. A posterior analysis suggests that the latent class membership may be related to an individual's age to some extent, or to diagnosis and treatment, while apart from energy dimension, no significant difference exists between latent groups, with regard to Multiple Sclerosis Quality of Life-54 scales. Conclusions: A quality of life preference-based utility measure for people with multiple sclerosis was developed. These utility values allow identification of a hierarchic priority among different aspects of quality of life and may allow physicians to develop a care programme tailored to patient needs. Springer International Publishing Switzerland, 2015 Quality of life nationallicence Multiple sclerosis nationallicence Preferences nationallicence Discrete choice experiment nationallicence Latent nationallicence Class nationallicence Rosato Rosalba Psychology Department, University of Turin, Via Verdi 10, 10126, Turin, Italy aut Testa Silvia Psychology Department, University of Turin, Via Verdi 10, 10126, Turin, Italy aut Oggero Alessandra II Neurological Department and CRESM (Referral Multiple Sclerosis Center), San Luigi Hospital, Orbassano, Turin, Italy aut Molinengo Giorgia Psychology Department, University of Turin, Via Verdi 10, 10126, Turin, Italy aut Bertolotto Antonio II Neurological Department and CRESM (Referral Multiple Sclerosis Center), San Luigi Hospital, Orbassano, Turin, Italy aut Quality of Life Research Springer International Publishing 24/9(2015-09-01), 2173-2182 0962-9343 24:9<2173 2015 24 11136 https://doi.org/10.1007/s11136-015-0952-4 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s11136-015-0952-4 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Rosato Rosalba Psychology Department, University of Turin, Via Verdi 10, 10126, Turin, Italy aut NATIONALLICENCE 700 1- Testa Silvia Psychology Department, University of Turin, Via Verdi 10, 10126, Turin, Italy aut NATIONALLICENCE 700 1- Oggero Alessandra II Neurological Department and CRESM (Referral Multiple Sclerosis Center), San Luigi Hospital, Orbassano, Turin, Italy aut NATIONALLICENCE 700 1- Molinengo Giorgia Psychology Department, University of Turin, Via Verdi 10, 10126, Turin, Italy aut NATIONALLICENCE 700 1- Bertolotto Antonio II Neurological Department and CRESM (Referral Multiple Sclerosis Center), San Luigi Hospital, Orbassano, Turin, Italy aut NATIONALLICENCE 773 0- Quality of Life Research Springer International Publishing 24/9(2015-09-01), 2173-2182 0962-9343 24:9<2173 2015 24 11136