caa a22 4500 60617835X CHVBK 20210128100756.0 cr unu---uuuuu 210128e20150901xx s 000 0 eng 10.1007/s11136-015-0947-1 doi (NATIONALLICENCE)springer-10.1007/s11136-015-0947-1 Assessing quality of life in Crohn's disease: development and validation of the Crohn's Life Impact Questionnaire (CLIQ) [Elektronische Daten] [Jeanette Wilburn, Stephen McKenna, James Twiss, Karen Kemp, Simon Campbell] Purpose: Despite the significant impact of Crohn's disease (CD) on patients' physical and emotional well-being, no CD-specific patient-reported outcome (PRO) measure is available for determining the efficacy of interventions. The objective of the study was to develop and validate the Crohn's Life Impact Scale (CLIQ), the first such measure. Methods: Questionnaire content was derived from qualitative interviews with CD patients and face and content validity assessed by cognitive debriefing interviews (CDIs) with patients. A postal survey was conducted to identify the final scale, confirm its unidimensionality and determine reproducibility and construct validity. A subset of the respondents was sent a second questionnaire package 2weeks after the first. The survey included the CLIQ, Nottingham Health Profile (NHP) and Unidimensional Fatigue Impact Scale (U-FIS). Results: Content analysis was conducted on the 30 interview transcripts and a draft scale produced. The CDIs indicated that the draft scale was relevant, clear and easy to use. The questionnaire package was completed by 273 CD patients (65.6% male; aged 16-79 (mean 43.9; SD 15.1) years). Of these, 104 also completed the second package. Rasch analysis confirmed a 27-item unidimensional QoL scale (p<0.05). Both internal consistency and test-retest reliability were high (0.91). Scores on the CLIQ were related to both physical and emotional impairments (NHP) and to fatigue (U-FIS). Conclusion: The CLIQ, the first CD-specific PRO, is unidimensional and has excellent psychometric properties. It should prove to be a valuable tool for evaluating the impact of CD and its treatment from the patients' perspective. Springer International Publishing Switzerland, 2015 Crohn's disease nationallicence Inflammatory bowel disease nationallicence IBD nationallicence Patient-reported outcome measure nationallicence PRO nationallicence Questionnaire nationallicence Quality of life nationallicence Wilburn Jeanette Galen Research Ltd, Enterprise House, Manchester Science Park, Lloyd Street North, M15 6SE, Manchester, UK aut McKenna Stephen Galen Research Ltd, Enterprise House, Manchester Science Park, Lloyd Street North, M15 6SE, Manchester, UK aut Twiss James Galen Research Ltd, Enterprise House, Manchester Science Park, Lloyd Street North, M15 6SE, Manchester, UK aut Kemp Karen Department of Gastroenterology, Manchester Royal Infirmary, M13 9WL, Manchester, UK aut Campbell Simon Department of Gastroenterology, Manchester Royal Infirmary, M13 9WL, Manchester, UK aut Quality of Life Research Springer International Publishing 24/9(2015-09-01), 2279-2288 0962-9343 24:9<2279 2015 24 11136 https://doi.org/10.1007/s11136-015-0947-1 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s11136-015-0947-1 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Wilburn Jeanette Galen Research Ltd, Enterprise House, Manchester Science Park, Lloyd Street North, M15 6SE, Manchester, UK aut NATIONALLICENCE 700 1- McKenna Stephen Galen Research Ltd, Enterprise House, Manchester Science Park, Lloyd Street North, M15 6SE, Manchester, UK aut NATIONALLICENCE 700 1- Twiss James Galen Research Ltd, Enterprise House, Manchester Science Park, Lloyd Street North, M15 6SE, Manchester, UK aut NATIONALLICENCE 700 1- Kemp Karen Department of Gastroenterology, Manchester Royal Infirmary, M13 9WL, Manchester, UK aut NATIONALLICENCE 700 1- Campbell Simon Department of Gastroenterology, Manchester Royal Infirmary, M13 9WL, Manchester, UK aut NATIONALLICENCE 773 0- Quality of Life Research Springer International Publishing 24/9(2015-09-01), 2279-2288 0962-9343 24:9<2279 2015 24 11136