caa a22 4500 606178414 CHVBK 20210128100756.0 cr unu---uuuuu 210128e20150901xx s 000 0 eng 10.1007/s11136-015-0964-0 doi (NATIONALLICENCE)springer-10.1007/s11136-015-0964-0 Health-related quality of life of Asian patients with end-stage renal disease (ESRD) in Singapore [Elektronische Daten] [F. Yang, K. Griva, T. Lau, A. Vathsala, E. Lee, H. Ng, N. Mooppil, M. Foo, S. Newman, K. Chia, N. Luo] Background: This study aimed to identify factors associated with the health-related quality of life (HRQOL) of multiethnic Asian end-stage renal disease (ESRD) patients treated with dialysis. The role of dialysis modality was also explored. Methods: Data used in this study were from two cross-sectional surveys of Singaporean ESRD patients on haemodialysis (HD) or peritoneal dialysis (PD). In both surveys, participants were assessed using the kidney disease quality of life (KDQOL) instrument and questions assessing socio-demographic characteristics. Clinical data including co-morbidity (measured by Charlson comorbidity index [CCI]), albumin level, haemoglobin level, and dialysis-related variables (e.g. dialysis vintage and dialysis adequacy) were retrieved from medical records. The 36-item KDQOL (KDQOL-36) was used to generate three summary scores (physical component summary [PCS], mental component summary [MCS] and kidney disease component summary [KDCS]) and two health utility scores (Short Form 6-dimension [SF-6D] and EuroQol 5-dimension [EQ-5D]). Linear regression analysis was performed to examine the association of factors with each of the HRQOL scale scores. Results: Five hundred and two patients were included in the study (mean age 57.1years; male 52.4%; HD 236, PD 266). Mean [standard deviation (SD)] PCS, MCS and KDCS scores were 37.9 (9.7), 46.4 (10.8) and 57.6 (18.1), respectively. Mean (SD) health utility score was 0.66 (0.12) for SF-6D and 0.60 (0.21) for EQ-5D. In multivariate regression analysis, factors found to be significantly associated with better HRQOL included: young (<45years) or old age (>60years), low CCI (<5), high albumin (≥37g/l) and high haemoglobin (≥11g/dl) with PCS; long dialysis vintage (≥3.5years) with MCS; old age, Malay ethnicity and PD modality with KDCS; low CCI, high albumin and high haemoglobin with EQ-5D and high albumin with SF-6D. Conclusions: Clinical characteristics are better predictors of HRQOL in ESRD patients than socio-demographics in Singapore. Dialysis modality has no impact on the health utility of those patients. Springer International Publishing Switzerland, 2015 Dialysis nationallicence End-stage renal disease nationallicence Health-related quality of life nationallicence HRQOL : Health-related quality of life nationallicence ESRD : End-stage renal disease nationallicence HD : Haemodialysis nationallicence PD : Peritoneal dialysis nationallicence SF-36 : 36-Item short form health survey nationallicence SF-12 : 12-Item short form health survey nationallicence EQ-5D : EuroQol 5-dimension nationallicence QALY : Quality-adjusted life year nationallicence KDQOL-SF : Kidney disease quality of life short form questionnaire nationallicence KDQOL-36 : Kidney disease quality of life 36-item questionnaire nationallicence SF-6D : Short Form 6-dimension nationallicence CCI : Charlson comorbidity index nationallicence PCS : Physical component summary nationallicence MCS : Mental component summary nationallicence KDCS : Kidney disease component summary nationallicence Yang F. Saw Swee Hock School of Public Health, National University of Singapore, Tahir Foundation Building, 12 Science Drive 2, 117549, Singapore, Singapore aut Griva K. Department of Psychology, Faculty of Arts and Social Sciences, National University of Singapore, Singapore, Singapore aut Lau T. Division of Nephrology, University Medicine Cluster, National University Health System, Singapore, Singapore aut Vathsala A. Division of Nephrology, University Medicine Cluster, National University Health System, Singapore, Singapore aut Lee E. Division of Nephrology, University Medicine Cluster, National University Health System, Singapore, Singapore aut Ng H. Department of Psychology, Faculty of Arts and Social Sciences, National University of Singapore, Singapore, Singapore aut Mooppil N. National Kidney Foundation, Singapore, Singapore aut Foo M. Department of Renal Medicine, Singapore General Hospital, Singapore, Singapore aut Newman S. Health Services Research, City University London, Northampton Square, EC1V0HB, London, UK aut Chia K. Saw Swee Hock School of Public Health, National University of Singapore, Tahir Foundation Building, 12 Science Drive 2, 117549, Singapore, Singapore aut Luo N. Saw Swee Hock School of Public Health, National University of Singapore, Tahir Foundation Building, 12 Science Drive 2, 117549, Singapore, Singapore aut Quality of Life Research Springer International Publishing 24/9(2015-09-01), 2163-2171 0962-9343 24:9<2163 2015 24 11136 https://doi.org/10.1007/s11136-015-0964-0 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s11136-015-0964-0 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Yang F. Saw Swee Hock School of Public Health, National University of Singapore, Tahir Foundation Building, 12 Science Drive 2, 117549, Singapore, Singapore aut NATIONALLICENCE 700 1- Griva K. Department of Psychology, Faculty of Arts and Social Sciences, National University of Singapore, Singapore, Singapore aut NATIONALLICENCE 700 1- Lau T. Division of Nephrology, University Medicine Cluster, National University Health System, Singapore, Singapore aut NATIONALLICENCE 700 1- Vathsala A. Division of Nephrology, University Medicine Cluster, National University Health System, Singapore, Singapore aut NATIONALLICENCE 700 1- Lee E. Division of Nephrology, University Medicine Cluster, National University Health System, Singapore, Singapore aut NATIONALLICENCE 700 1- Ng H. Department of Psychology, Faculty of Arts and Social Sciences, National University of Singapore, Singapore, Singapore aut NATIONALLICENCE 700 1- Mooppil N. National Kidney Foundation, Singapore, Singapore aut NATIONALLICENCE 700 1- Foo M. Department of Renal Medicine, Singapore General Hospital, Singapore, Singapore aut NATIONALLICENCE 700 1- Newman S. Health Services Research, City University London, Northampton Square, EC1V0HB, London, UK aut NATIONALLICENCE 700 1- Chia K. Saw Swee Hock School of Public Health, National University of Singapore, Tahir Foundation Building, 12 Science Drive 2, 117549, Singapore, Singapore aut NATIONALLICENCE 700 1- Luo N. Saw Swee Hock School of Public Health, National University of Singapore, Tahir Foundation Building, 12 Science Drive 2, 117549, Singapore, Singapore aut NATIONALLICENCE 773 0- Quality of Life Research Springer International Publishing 24/9(2015-09-01), 2163-2171 0962-9343 24:9<2163 2015 24 11136