caa a22 4500 606178422 CHVBK 20210128100756.0 cr unu---uuuuu 210128e20150901xx s 000 0 eng 10.1007/s11136-015-0958-y doi (NATIONALLICENCE)springer-10.1007/s11136-015-0958-y Psychometric evaluation of the EORTC QLQ-PR25 questionnaire in assessing health-related quality of life in prostate cancer survivors: a curate's egg [Elektronische Daten] [Eamonn O'Leary, Frances Drummond, Anna Gavin, Heather Kinnear, Linda Sharp] Purpose: The EORTC QLQ-PR25 was primarily developed to measure disease-specific health-related quality of life (HRQoL) of prostate cancer (PCa) patients undergoing active treatment. The growing number of cancer survivors has focussed interest on assessing survivors' HRQoL. We evaluated psychometric properties of the EORTC QLQ-PR25 questionnaire amongst PCa survivors. Methods: A postal questionnaire, including the QLQ-PR25, was administered to 6559 PCa survivors 2-18years post-diagnosis, identified through population-based cancer registries in Ireland; 3348 participated. The QLQ-PR25 has been suggested to have five multi-item subscales measuring urinary (US), bowel (BS) and hormone treatment-related symptoms (TS), sexual activity (SA) and sexual functioning (SF), and a single item measuring bother due to using incontinence aids (IA). Reliability analysis, divergent validity, discriminant validity (compared to EORTC QLQ-C30, DASS-21 and EuroQoL EQ-5D-5L), and exploratory and confirmatory factor analysis (EFA, CFA) were undertaken. Results: The percentage of survivors completing QLQ-PR25 subscales was: US-79%; IA-20%; BS-83%; TS-86%; SA-87%; and SF-26%. Reliability was acceptable (Cronbach's α>0.7) for three subscales (US, SA, SF). The instrument discriminated well between clinically distinct groups, especially those defined by primary treatment(s) and stage at diagnosis. The SA and SF subscales showed good discriminant validity compared to QLQ-C30, DASS-21 and EQ-5D-5L; other subscales did not. EFA reproduced a near fit to the proposed factor structure. CFA confirmed this. Conclusion: This is the largest ever QLQ-PR25 validation study. When used in PCa survivors, although the proposed factor structure was confirmed, some of the subscales (e.g. BS and TS) showed poor reliability, a lack of discriminant validity and moderate levels of item non-response. Springer International Publishing Switzerland, 2015 Health-related quality of life nationallicence Prostate cancer nationallicence Survivors nationallicence QLQ-PR25 nationallicence O'Leary Eamonn National Cancer Registry, Cork, Ireland aut Drummond Frances National Cancer Registry, Cork, Ireland aut Gavin Anna Northern Ireland Cancer Registry, Belfast, UK aut Kinnear Heather Northern Ireland Cancer Registry, Belfast, UK aut Sharp Linda National Cancer Registry, Cork, Ireland aut Quality of Life Research Springer International Publishing 24/9(2015-09-01), 2219-2230 0962-9343 24:9<2219 2015 24 11136 https://doi.org/10.1007/s11136-015-0958-y text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s11136-015-0958-y text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- O'Leary Eamonn National Cancer Registry, Cork, Ireland aut NATIONALLICENCE 700 1- Drummond Frances National Cancer Registry, Cork, Ireland aut NATIONALLICENCE 700 1- Gavin Anna Northern Ireland Cancer Registry, Belfast, UK aut NATIONALLICENCE 700 1- Kinnear Heather Northern Ireland Cancer Registry, Belfast, UK aut NATIONALLICENCE 700 1- Sharp Linda National Cancer Registry, Cork, Ireland aut NATIONALLICENCE 773 0- Quality of Life Research Springer International Publishing 24/9(2015-09-01), 2219-2230 0962-9343 24:9<2219 2015 24 11136