caa a22 4500 60617849X CHVBK 20210128100757.0 cr unu---uuuuu 210128e20150901xx s 000 0 eng 10.1007/s11136-015-0950-6 doi (NATIONALLICENCE)springer-10.1007/s11136-015-0950-6 Association between single-nucleotide polymorphisms in growth factor genes and quality of life in men with prostate cancer and the general population [Elektronische Daten] [Kimberly Alexander, Suzanne Chambers, Amanda Spurdle, Jyotsna Batra, Felicity Lose, Tracy O'Mara, Robert Gardiner, Joanne Aitken, Judith Clements, Mary-Anne Kedda, Monika Janda] Purpose: Improved survival for men with prostate cancer has led to increased attention to factors influencing quality of life (QOL). As protein levels of vascular endothelial growth factor (VEGF) and insulin-like growth factor 1 (IGF-1) have been reported to be associated with QOL in people with cancer, we sought to identify whether single-nucleotide polymorphisms (SNPs) of these genes were associated with QOL in men with prostate cancer. Methods: Multiple linear regression of two data sets (including approximately 750 men newly diagnosed with prostate cancer and 550 men from the general population) was used to investigate SNPs of VEGF and IGF-1 (10 SNPs in total) for associations with QOL (measured by the SF-36v2 health survey). Results: Men with prostate cancer who carried the minor ‘T' allele for IGF-1 SNP rs35767 had higher mean Role-Physical scale scores (≥0.3 SD) compared to non-carriers (p<0.05). While this association was not identified in men from the general population, one IGF-1 SNP rs7965399 was associated with higher mean Bodily Pain scale scores in men from the general population that was not found in men with prostate cancer. Men from the general population who carried the rare ‘C' allele had higher mean Bodily Pain scale scores (≥0.3 SD) than non-carriers (p<0.05). Conclusions: Through identifying SNPs that are associated with QOL in men with prostate cancer and men from the general population, this study adds to the mapping of complex interrelationships that influence QOL and suggests a role for IGF-I in physical QOL outcomes. Future research may identify biomarkers associated with increased risk of poor QOL that could assist in the provision of pre-emptive support for those identified at risk. Springer International Publishing Switzerland, 2015 Quality of life nationallicence Cancer nationallicence Oncology nationallicence Polymorphisms nationallicence Vascular endothelial growth factor nationallicence Insulin-like growth factor 1 nationallicence Alexander Kimberly Institute of Health and Biomedical Innovation (IHBI), School of Nursing, Queensland University of Technology (QUT), 4059, Kelvin Grove, Brisbane, QLD, Australia aut Chambers Suzanne Griffith Health Institute, Griffith University, Gold Coast, QLD, Australia aut Spurdle Amanda Molecular Cancer Epidemiology Group, Genetics and Population Health Division, QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia aut Batra Jyotsna Australian Prostate Cancer Research Centre-Queensland, Institute of Health and Biomedical Innovation (IHBI), Queensland University of Technology (QUT), Brisbane, QLD, Australia aut Lose Felicity Molecular Cancer Epidemiology Group, Genetics and Population Health Division, QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia aut O'Mara Tracy Molecular Cancer Epidemiology Group, Genetics and Population Health Division, QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia aut Gardiner Robert Centre for Clinical Research, The University of Queensland, Brisbane, QLD, Australia aut Aitken Joanne Viertel Centre for Cancer Research, Cancer Council Queensland, Brisbane, QLD, Australia aut Clements Judith Australian Prostate Cancer Research Centre-Queensland, Institute of Health and Biomedical Innovation (IHBI), Queensland University of Technology (QUT), Brisbane, QLD, Australia aut Kedda Mary-Anne Australian Prostate Cancer Research Centre-Queensland, Institute of Health and Biomedical Innovation (IHBI), Queensland University of Technology (QUT), Brisbane, QLD, Australia aut Janda Monika Institute of Health and Biomedical Innovation (IHBI), School of Public Health and Social Work, Queensland University of Technology (QUT), Brisbane, QLD, Australia aut Quality of Life Research Springer International Publishing 24/9(2015-09-01), 2183-2193 0962-9343 24:9<2183 2015 24 11136 https://doi.org/10.1007/s11136-015-0950-6 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s11136-015-0950-6 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Alexander Kimberly Institute of Health and Biomedical Innovation (IHBI), School of Nursing, Queensland University of Technology (QUT), 4059, Kelvin Grove, Brisbane, QLD, Australia aut NATIONALLICENCE 700 1- Chambers Suzanne Griffith Health Institute, Griffith University, Gold Coast, QLD, Australia aut NATIONALLICENCE 700 1- Spurdle Amanda Molecular Cancer Epidemiology Group, Genetics and Population Health Division, QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia aut NATIONALLICENCE 700 1- Batra Jyotsna Australian Prostate Cancer Research Centre-Queensland, Institute of Health and Biomedical Innovation (IHBI), Queensland University of Technology (QUT), Brisbane, QLD, Australia aut NATIONALLICENCE 700 1- Lose Felicity Molecular Cancer Epidemiology Group, Genetics and Population Health Division, QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia aut NATIONALLICENCE 700 1- O'Mara Tracy Molecular Cancer Epidemiology Group, Genetics and Population Health Division, QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia aut NATIONALLICENCE 700 1- Gardiner Robert Centre for Clinical Research, The University of Queensland, Brisbane, QLD, Australia aut NATIONALLICENCE 700 1- Aitken Joanne Viertel Centre for Cancer Research, Cancer Council Queensland, Brisbane, QLD, Australia aut NATIONALLICENCE 700 1- Clements Judith Australian Prostate Cancer Research Centre-Queensland, Institute of Health and Biomedical Innovation (IHBI), Queensland University of Technology (QUT), Brisbane, QLD, Australia aut NATIONALLICENCE 700 1- Kedda Mary-Anne Australian Prostate Cancer Research Centre-Queensland, Institute of Health and Biomedical Innovation (IHBI), Queensland University of Technology (QUT), Brisbane, QLD, Australia aut NATIONALLICENCE 700 1- Janda Monika Institute of Health and Biomedical Innovation (IHBI), School of Public Health and Social Work, Queensland University of Technology (QUT), Brisbane, QLD, Australia aut NATIONALLICENCE 773 0- Quality of Life Research Springer International Publishing 24/9(2015-09-01), 2183-2193 0962-9343 24:9<2183 2015 24 11136