caa a22 4500 606178627 CHVBK 20210128100757.0 cr unu---uuuuu 210128e20150701xx s 000 0 eng 10.1007/s11136-014-0892-4 doi (NATIONALLICENCE)springer-10.1007/s11136-014-0892-4 Mapping the disease-specific LupusQoL to the SF-6D [Elektronische Daten] [Rachel Meacock, Mark Harrison, Kathleen McElhone, Janice Abbott, Sahena Haque, Ian Bruce, Lee-Suan Teh] Purpose: To derive a mapping algorithm to predict SF-6D utility scores from the non-preference-based LupusQoL and test the performance of the developed algorithm on a separate independent validation data set. Method: LupusQoL and SF-6D data were collected from 320 patients with systemic lupus erythematosus (SLE) attending routine rheumatology outpatient appointments at seven centres in the UK. Ordinary least squares (OLS) regression was used to estimate models of increasing complexity in order to predict individuals' SF-6D utility scores from their responses to the LupusQoL questionnaire. Model performance was judged on predictive ability through the size and pattern of prediction errors generated. The performance of the selected model was externally validated on an independent data set containing 113 female SLE patients who had again completed both the LupusQoL and SF-36 questionnaires. Results: Four of the eight LupusQoL domains (physical health, pain, emotional health, and fatigue) were selected as dependent variables in the final model. Overall model fit was good, with R2 0.7219, MAE 0.0557, and RMSE 0.0706 when applied to the estimation data set, and R2 0.7431, MAE 0.0528, and RMSE 0.0663 when applied to the validation sample. Conclusion: This study provides a method by which health state utility values can be estimated from patient responses to the non-preference-based LupusQoL, generalisable beyond the data set upon which it was estimated. Despite concerns over the use of OLS to develop mapping algorithms, we find this method to be suitable in this case due to the normality of the SF-6D data. Springer International Publishing Switzerland, 2014 Mapping nationallicence SF-6D nationallicence LupusQoL nationallicence Quality of life nationallicence Utility nationallicence Systemic lupus erythematosus nationallicence Meacock Rachel The University of Manchester, 4.311 Jean McFarlane Building, Oxford Road, M15 4QE, Manchester, UK aut Harrison Mark The University of Manchester, 4.311 Jean McFarlane Building, Oxford Road, M15 4QE, Manchester, UK aut McElhone Kathleen Royal Blackburn Hospital, Blackburn, UK aut Abbott Janice University of Central Lancashire, Preston, UK aut Haque Sahena University Hospital of South Manchester, Manchester, UK aut Bruce Ian The University of Manchester, 4.311 Jean McFarlane Building, Oxford Road, M15 4QE, Manchester, UK aut Teh Lee-Suan Royal Blackburn Hospital, Blackburn, UK aut Quality of Life Research Springer International Publishing 24/7(2015-07-01), 1749-1758 0962-9343 24:7<1749 2015 24 11136 https://doi.org/10.1007/s11136-014-0892-4 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s11136-014-0892-4 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Meacock Rachel The University of Manchester, 4.311 Jean McFarlane Building, Oxford Road, M15 4QE, Manchester, UK aut NATIONALLICENCE 700 1- Harrison Mark The University of Manchester, 4.311 Jean McFarlane Building, Oxford Road, M15 4QE, Manchester, UK aut NATIONALLICENCE 700 1- McElhone Kathleen Royal Blackburn Hospital, Blackburn, UK aut NATIONALLICENCE 700 1- Abbott Janice University of Central Lancashire, Preston, UK aut NATIONALLICENCE 700 1- Haque Sahena University Hospital of South Manchester, Manchester, UK aut NATIONALLICENCE 700 1- Bruce Ian The University of Manchester, 4.311 Jean McFarlane Building, Oxford Road, M15 4QE, Manchester, UK aut NATIONALLICENCE 700 1- Teh Lee-Suan Royal Blackburn Hospital, Blackburn, UK aut NATIONALLICENCE 773 0- Quality of Life Research Springer International Publishing 24/7(2015-07-01), 1749-1758 0962-9343 24:7<1749 2015 24 11136