caa a22 4500 606178651 CHVBK 20210128100757.0 cr unu---uuuuu 210128e20150701xx s 000 0 eng 10.1007/s11136-014-0896-0 doi (NATIONALLICENCE)springer-10.1007/s11136-014-0896-0 Thyroid-specific questions on work ability showed known-groups validity among Danes with thyroid diseases [Elektronische Daten] [Mette Nexo, Torquil Watt, Steen Bonnema, Laszlo Hegedüs, Åse Rasmussen, Ulla Feldt-Rasmussen, Jakob Bjorner] Purpose: We aimed to identify the best approach to work ability assessment in patients with thyroid disease by evaluating the factor structure, measurement equivalence, known-groups validity, and predictive validity of a broad set of work ability items. Methods: Based on the literature and interviews with thyroid patients, 24 work ability items were selected from previous questionnaires, revised, or developed anew. Items were tested among 632 patients with thyroid disease (non-toxic goiter, toxic nodular goiter, Graves' disease (with or without orbitopathy), autoimmune hypothyroidism, and other thyroid diseases), 391 of which had participated in a study 5years previously. Responses to select items were compared to general population data. We used confirmatory factor analyses for categorical data, logistic regression analyses and tests of differential item function, and head-to-head comparisons of relative validity in distinguishing known groups. Results: Although all work ability items loaded on a common factor, the optimal factor solution included five factors: role physical, role emotional, thyroid-specific limitations, work limitations (without disease attribution), and work performance. The scale on thyroid-specific limitations showed the most power in distinguishing clinical groups and time since diagnosis. A global single item proved useful for comparisons with the general population, and a thyroid-specific item predicted labor market exclusion within the next 5years (OR 5.0, 95% CI 2.7-9.1). Conclusions: Items on work limitations with attribution to thyroid disease were most effective in detecting impact on work ability and showed good predictive validity. Generic work ability items remain useful for general population comparisons. The Author(s), 2014 Thyroid disease nationallicence QOL nationallicence Scale validation nationallicence Work ability nationallicence Hyperthyroidism nationallicence Hypothyroidism nationallicence Nexo Mette The National Research Centre for the Working Environment, Lersø Parkallé 105, 2100, Copenhagen, Denmark aut Watt Torquil Department of Medical Endocrinology, Copenhagen University Hospital (Rigshospitalet), Blegdamsvej 9, 2100, Copenhagen, Denmark aut Bonnema Steen Department of Endocrinology and Metabolism, Odense University Hospital, Sdr. Boulevard 29, 5000, Odense, Denmark aut Hegedüs Laszlo Department of Endocrinology and Metabolism, Odense University Hospital, Sdr. Boulevard 29, 5000, Odense, Denmark aut Rasmussen Åse Department of Medical Endocrinology, Copenhagen University Hospital (Rigshospitalet), Blegdamsvej 9, 2100, Copenhagen, Denmark aut Feldt-Rasmussen Ulla Department of Medical Endocrinology, Copenhagen University Hospital (Rigshospitalet), Blegdamsvej 9, 2100, Copenhagen, Denmark aut Bjorner Jakob The National Research Centre for the Working Environment, Lersø Parkallé 105, 2100, Copenhagen, Denmark aut Quality of Life Research Springer International Publishing 24/7(2015-07-01), 1615-1627 0962-9343 24:7<1615 2015 24 11136 https://doi.org/10.1007/s11136-014-0896-0 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s11136-014-0896-0 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Nexo Mette The National Research Centre for the Working Environment, Lersø Parkallé 105, 2100, Copenhagen, Denmark aut NATIONALLICENCE 700 1- Watt Torquil Department of Medical Endocrinology, Copenhagen University Hospital (Rigshospitalet), Blegdamsvej 9, 2100, Copenhagen, Denmark aut NATIONALLICENCE 700 1- Bonnema Steen Department of Endocrinology and Metabolism, Odense University Hospital, Sdr. Boulevard 29, 5000, Odense, Denmark aut NATIONALLICENCE 700 1- Hegedüs Laszlo Department of Endocrinology and Metabolism, Odense University Hospital, Sdr. Boulevard 29, 5000, Odense, Denmark aut NATIONALLICENCE 700 1- Rasmussen Åse Department of Medical Endocrinology, Copenhagen University Hospital (Rigshospitalet), Blegdamsvej 9, 2100, Copenhagen, Denmark aut NATIONALLICENCE 700 1- Feldt-Rasmussen Ulla Department of Medical Endocrinology, Copenhagen University Hospital (Rigshospitalet), Blegdamsvej 9, 2100, Copenhagen, Denmark aut NATIONALLICENCE 700 1- Bjorner Jakob The National Research Centre for the Working Environment, Lersø Parkallé 105, 2100, Copenhagen, Denmark aut NATIONALLICENCE 773 0- Quality of Life Research Springer International Publishing 24/7(2015-07-01), 1615-1627 0962-9343 24:7<1615 2015 24 11136