caa a22 4500 606179038 CHVBK 20210128100759.0 cr unu---uuuuu 210128e20150301xx s 000 0 eng 10.1007/s11136-014-0787-4 doi (NATIONALLICENCE)springer-10.1007/s11136-014-0787-4 Estimating the minimum important change in the 15D scores [Elektronische Daten] [Soili Alanne, Risto Roine, Pirjo Räsänen, Tarja Vainiola, Harri Sintonen] Purpose: To facilitate the interpretation of empirical results produced by the 15D, a generic, preference-based instrument for measuring health-related quality of life (HRQoL), a subjective five-category global assessment scale (GAS) was used as an external anchor to determine the minimum important change (MIC) in the 15D scores. Methods: Altogether 4,903 hospital patients representing sixteen disease entities and having the 15D score at baseline repeated the HRQoL assessment at 6months after treatment and answered the question: compared to the situation before treatment, my overall health status is now (1) much better, (2) slightly better, (3) much the same, (4) slightly worse, (5) much worse. Regression analysis was used to estimate the MIC for improvement/deterioration, defined as the lower/upper limit of 99.9% confidence interval of the regression coefficient, standardized for baseline HRQoL, for categories (2) and (4), respectively, and confirmed by ROC curve analysis. Results: The limits or intervals for classifying the changes of 15D scores into GAS categories were >.035 for (1), .015-.035 for (2),>−.015 and<.015 for (3), −.035-−.015 for (4) and <−.035 for (5). The lower/upper limits of ±.015 for categories (2) and (4) can be regarded as the generic MIC thresholds for improvement/deterioration, respectively. Conclusions: The generic MICs for the change of 15D scores are ±.015. Follow-up studies using the 15D should report the mean change in the 15D score, its statistical significance, relationship to the MIC, and the distribution of the changes of the 15D scores into the five categories. Springer International Publishing Switzerland, 2014 15D nationallicence Health-related quality of life nationallicence Global assessment scale nationallicence Minimum important change nationallicence Minimum clinically important difference nationallicence Alanne Soili Department of Clinical Nutrition, Seinäjoki Central Hospital, The Hospital District of South Ostrobothnia, Seinäjoki, Finland aut Roine Risto Group Administration, Helsinki and Uusimaa Hospital Group, Helsinki, Finland aut Räsänen Pirjo External Evaluation Unit, Helsinki and Uusimaa Hospital Group, Helsinki, Finland aut Vainiola Tarja Group Administration, Helsinki and Uusimaa Hospital Group, Helsinki, Finland aut Sintonen Harri Department of Public Health/Hjelt Institute, University of Helsinki, P.O. Box 40, 00014, Helsinki, Finland aut Quality of Life Research Springer International Publishing 24/3(2015-03-01), 599-606 0962-9343 24:3<599 2015 24 11136 https://doi.org/10.1007/s11136-014-0787-4 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s11136-014-0787-4 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Alanne Soili Department of Clinical Nutrition, Seinäjoki Central Hospital, The Hospital District of South Ostrobothnia, Seinäjoki, Finland aut NATIONALLICENCE 700 1- Roine Risto Group Administration, Helsinki and Uusimaa Hospital Group, Helsinki, Finland aut NATIONALLICENCE 700 1- Räsänen Pirjo External Evaluation Unit, Helsinki and Uusimaa Hospital Group, Helsinki, Finland aut NATIONALLICENCE 700 1- Vainiola Tarja Group Administration, Helsinki and Uusimaa Hospital Group, Helsinki, Finland aut NATIONALLICENCE 700 1- Sintonen Harri Department of Public Health/Hjelt Institute, University of Helsinki, P.O. Box 40, 00014, Helsinki, Finland aut NATIONALLICENCE 773 0- Quality of Life Research Springer International Publishing 24/3(2015-03-01), 599-606 0962-9343 24:3<599 2015 24 11136