caa a22 4500 606179070 CHVBK 20210128100759.0 cr unu---uuuuu 210128e20150301xx s 000 0 eng 10.1007/s11136-014-0798-1 doi (NATIONALLICENCE)springer-10.1007/s11136-014-0798-1 Cross-cultural validity of the thyroid-specific quality-of-life patient-reported outcome measure, ThyPRO [Elektronische Daten] [Torquil Watt, Giuseppe Barbesino, Jakob Bjorner, Steen Bonnema, Branka Bukvic, Russell Drummond, Mogens Groenvold, Laszlo Hegedüs, Valeska Kantzer, Kathryn Lasch, Claudio Marcocci, Anjali Mishra, Romana Netea-Maier, Merel Ekker, Ivan Paunovic, Terence Quinn, Åse Rasmussen, Audrey Russell, Mayilvaganan Sabaretnam, Johannes Smit, Ove Törring, Vladan Zivaljevic, Ulla Feldt-Rasmussen] Background and purpose: Thyroid diseases are common and often affect quality of life (QoL). No cross-culturally validated patient-reported outcome measuring thyroid-related QoL is available. The purpose of the present study was to test the cross-cultural validity of the newly developed thyroid-related patient-reported outcome ThyPRO, using tests for differential item functioning (DIF) according to language version. Methods: The ThyPRO consists of 85 items summarized in 13 multi-item scales and one single item. Scales cover physical and mental symptoms, well-being and function as well as social and daily function and cosmetic concerns. Translation applied standard forward-backward methodology with subsequent cognitive interviews and reviews. Responses (N=1,810) to the ThyPRO were collected in seven countries: UK (n=166), The Netherlands (n=147), Serbia (n=150), Italy (n=110), India (n=148), Denmark (n=902) and Sweden (n=187). Translated versions were compared pairwise to the English version by examining uniform and nonuniform DIF, i.e., whether patients from different countriesrespond differentlyto a particular item, although they have identical level of the concept measuredby the item. Analyses were controlled for thyroid diagnosis. DIF was investigated by ordinal logistic regression, testing for both statistical significance and magnitude (ΔR 2>0.02). Scale level was estimated by the sum score, after purification. Results: For twelve of the 84 tested items, DIF was identified in more than one language. Eight of these were small, but four were indicative of possible low translatability. Twenty-one instances of DIF in single languages were identified, indicating potential problems with the particular translation. However, only seven were of a magnitude which could affect scale scores, most of which could be explained by sample differences not controlled for. Conclusion: The ThyPRO has good cross-cultural validity with only minor cross-cultural invariance and is recommended for use in international multicenter studies. Springer International Publishing Switzerland, 2014 Thyroid diseases nationallicence Quality of life nationallicence Patient-reported outcome measure nationallicence Cross-cultural validity nationallicence Differential item functioning nationallicence Watt Torquil Department of Endocrinology, Copenhagen University Hospital Rigshospitalet, Blegdamsvej 9, 2100, Copenhagen Ø, Denmark aut Barbesino Giuseppe Massachusetts General Hospital, Boston, MA, USA aut Bjorner Jakob QualityMetric, Lincoln, RI, USA aut Bonnema Steen Department of Endocrinology and Metabolism, Odense University Hospital, Odense, Denmark aut Bukvic Branka Clinical Centre of Serbia, Belgrade, Serbia aut Drummond Russell Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, Scotland, UK aut Groenvold Mogens Research Unit, Department of Palliative Medicine, Bispebjerg Hospital and Department of Health Service Research, University of Copenhagen, Copenhagen, Denmark aut Hegedüs Laszlo Department of Endocrinology and Metabolism, Odense University Hospital, Odense, Denmark aut Kantzer Valeska Health Research Associates Inc., Mountlake Terrace, WA, USA aut Lasch Kathryn Pharmerit International, Bethesda, MD, USA aut Marcocci Claudio University Department of Clinical and Experimental Medicine, University of Pisa, and Endocrine Unit 2, University Hospital of Pisa, Pisa, Italy aut Mishra Anjali Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India aut Netea-Maier Romana Department of Internal Medicine, Radboud University Medical Center Nijmegen, Nijmegen, Netherlands aut Ekker Merel Department of Internal Medicine, Radboud University Medical Center Nijmegen, Nijmegen, Netherlands aut Paunovic Ivan Clinical Centre of Serbia, Belgrade, Serbia aut Quinn Terence Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, Scotland, UK aut Rasmussen Åse Department of Endocrinology, Copenhagen University Hospital Rigshospitalet, Blegdamsvej 9, 2100, Copenhagen Ø, Denmark aut Russell Audrey University College Cork, Cork, Ireland aut Sabaretnam Mayilvaganan Christian Medical College, Vellore, India aut Smit Johannes Department of Internal Medicine, Radboud University Medical Center Nijmegen, Nijmegen, Netherlands aut Törring Ove Institution for Clinical Science and Education, Karolinska Institutet Södersjukhuset, Stockholm, Sweden aut Zivaljevic Vladan Clinical Centre of Serbia, Belgrade, Serbia aut Feldt-Rasmussen Ulla Department of Endocrinology, Copenhagen University Hospital Rigshospitalet, Blegdamsvej 9, 2100, Copenhagen Ø, Denmark aut Quality of Life Research Springer International Publishing 24/3(2015-03-01), 769-780 0962-9343 24:3<769 2015 24 11136 https://doi.org/10.1007/s11136-014-0798-1 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s11136-014-0798-1 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Watt Torquil Department of Endocrinology, Copenhagen University Hospital Rigshospitalet, Blegdamsvej 9, 2100, Copenhagen Ø, Denmark aut NATIONALLICENCE 700 1- Barbesino Giuseppe Massachusetts General Hospital, Boston, MA, USA aut NATIONALLICENCE 700 1- Bjorner Jakob QualityMetric, Lincoln, RI, USA aut NATIONALLICENCE 700 1- Bonnema Steen Department of Endocrinology and Metabolism, Odense University Hospital, Odense, Denmark aut NATIONALLICENCE 700 1- Bukvic Branka Clinical Centre of Serbia, Belgrade, Serbia aut NATIONALLICENCE 700 1- Drummond Russell Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, Scotland, UK aut NATIONALLICENCE 700 1- Groenvold Mogens Research Unit, Department of Palliative Medicine, Bispebjerg Hospital and Department of Health Service Research, University of Copenhagen, Copenhagen, Denmark aut NATIONALLICENCE 700 1- Hegedüs Laszlo Department of Endocrinology and Metabolism, Odense University Hospital, Odense, Denmark aut NATIONALLICENCE 700 1- Kantzer Valeska Health Research Associates Inc., Mountlake Terrace, WA, USA aut NATIONALLICENCE 700 1- Lasch Kathryn Pharmerit International, Bethesda, MD, USA aut NATIONALLICENCE 700 1- Marcocci Claudio University Department of Clinical and Experimental Medicine, University of Pisa, and Endocrine Unit 2, University Hospital of Pisa, Pisa, Italy aut NATIONALLICENCE 700 1- Mishra Anjali Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India aut NATIONALLICENCE 700 1- Netea-Maier Romana Department of Internal Medicine, Radboud University Medical Center Nijmegen, Nijmegen, Netherlands aut NATIONALLICENCE 700 1- Ekker Merel Department of Internal Medicine, Radboud University Medical Center Nijmegen, Nijmegen, Netherlands aut NATIONALLICENCE 700 1- Paunovic Ivan Clinical Centre of Serbia, Belgrade, Serbia aut NATIONALLICENCE 700 1- Quinn Terence Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, Scotland, UK aut NATIONALLICENCE 700 1- Rasmussen Åse Department of Endocrinology, Copenhagen University Hospital Rigshospitalet, Blegdamsvej 9, 2100, Copenhagen Ø, Denmark aut NATIONALLICENCE 700 1- Russell Audrey University College Cork, Cork, Ireland aut NATIONALLICENCE 700 1- Sabaretnam Mayilvaganan Christian Medical College, Vellore, India aut NATIONALLICENCE 700 1- Smit Johannes Department of Internal Medicine, Radboud University Medical Center Nijmegen, Nijmegen, Netherlands aut NATIONALLICENCE 700 1- Törring Ove Institution for Clinical Science and Education, Karolinska Institutet Södersjukhuset, Stockholm, Sweden aut NATIONALLICENCE 700 1- Zivaljevic Vladan Clinical Centre of Serbia, Belgrade, Serbia aut NATIONALLICENCE 700 1- Feldt-Rasmussen Ulla Department of Endocrinology, Copenhagen University Hospital Rigshospitalet, Blegdamsvej 9, 2100, Copenhagen Ø, Denmark aut NATIONALLICENCE 773 0- Quality of Life Research Springer International Publishing 24/3(2015-03-01), 769-780 0962-9343 24:3<769 2015 24 11136