caa a22 4500 606179143 CHVBK 20210128100759.0 cr unu---uuuuu 210128e20150301xx s 000 0 eng 10.1007/s11136-014-0790-9 doi (NATIONALLICENCE)springer-10.1007/s11136-014-0790-9 Creating meaningful cut-scores for Neuro-QOL measures of fatigue, physical functioning, and sleep disturbance using standard setting with patients and providers [Elektronische Daten] [Karon Cook, David Victorson, David Cella, Benjamin Schalet, Deborah Miller] Purpose: To establish clinically relevant classifications of health outcome scores for four Neuro-QOL measures (lower extremity function, upper extremity function, fatigue, and sleep disturbance). Methods: We employed a modified educational standard-setting methodology to identify cut-scores for symptom severity. Clinical vignettes were developed to represent graduated levels of symptom severity. A clinician panel and a panel of persons with multiple sclerosis (PwMS) were recruited, and, in separate, 1-day meetings, the panelists identified adjacent vignettes they judged to represent the threshold between two levels of severity for a given domain (e.g., threshold between a vignette that indicated "no problems” with sleep and the adjacent one that represented "mild problems” with sleep). Working independently, each panel (PwMS and clinicians) reached consensus on its recommended thresholds for each of the four targeted measures. Cut-scores were defined as the mean location for each pair of threshold vignettes. Results: PwMS and clinician panels derived identical thresholds for severity levels of lower extremity function and sleep disturbance, but slightly different ones for upper extremity function and fatigue. In every case of divergence, PwMS set higher thresholds for more severe classifications of symptoms (by 0.5 SDs) than did clinicians. Conclusions: The modified bookmarking method is effective for defining thresholds for symptom severity based on self-reported outcome scores and consensus judgments. Derived cut-scores and severity levels provide an interpretative context for Neuro-QOL scores. Future studies should explore whether these findings can be replicated and evaluate the validity of the classifications compared to external criteria. Springer International Publishing Switzerland, 2014 Interpretation of HRQOL data nationallicence Item response theory (IRT) nationallicence Psychometric methods/scaling nationallicence Neurology nationallicence Multiple sclerosis nationallicence Cook Karon Department of Medical Social Sciences, Northwestern University Feinberg School of Medicine, Chicago, IL, USA aut Victorson David Department of Medical Social Sciences, Northwestern University Feinberg School of Medicine, Chicago, IL, USA aut Cella David Department of Medical Social Sciences, Northwestern University Feinberg School of Medicine, Chicago, IL, USA aut Schalet Benjamin Department of Medical Social Sciences, Northwestern University Feinberg School of Medicine, Chicago, IL, USA aut Miller Deborah Mellen Center, Cleveland Clinic Foundation, Cleveland, OH, USA aut Quality of Life Research Springer International Publishing 24/3(2015-03-01), 575-589 0962-9343 24:3<575 2015 24 11136 https://doi.org/10.1007/s11136-014-0790-9 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s11136-014-0790-9 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Cook Karon Department of Medical Social Sciences, Northwestern University Feinberg School of Medicine, Chicago, IL, USA aut NATIONALLICENCE 700 1- Victorson David Department of Medical Social Sciences, Northwestern University Feinberg School of Medicine, Chicago, IL, USA aut NATIONALLICENCE 700 1- Cella David Department of Medical Social Sciences, Northwestern University Feinberg School of Medicine, Chicago, IL, USA aut NATIONALLICENCE 700 1- Schalet Benjamin Department of Medical Social Sciences, Northwestern University Feinberg School of Medicine, Chicago, IL, USA aut NATIONALLICENCE 700 1- Miller Deborah Mellen Center, Cleveland Clinic Foundation, Cleveland, OH, USA aut NATIONALLICENCE 773 0- Quality of Life Research Springer International Publishing 24/3(2015-03-01), 575-589 0962-9343 24:3<575 2015 24 11136