caa a22 4500 606179178 CHVBK 20210128100800.0 cr unu---uuuuu 210128e20150301xx s 000 0 eng 10.1007/s11136-014-0801-x doi (NATIONALLICENCE)springer-10.1007/s11136-014-0801-x A qualitative study of the impact of severe asthma and its treatment showing that treatment burden is neglected in existing asthma assessment scales [Elektronische Daten] [Michael Hyland, Ben Whalley, Rupert Jones, Matthew Masoli] Background: People with severe asthma experience significant respiratory symptoms and suffer adverse effects of oral corticosteroids (OCS), including disturbed mood and physical symptoms. OCS impacts on health-related quality of life (HRQoL) have not been quantified. Asthma HRQoL scales are valid as outcome measures for patients requiring OCS only if they assess the deficits imposed by OCS. Aims: The aim of this study was to compare the burden of disease and treatment in patients with severe asthma with items in eight asthma-specific HRQoL scales. Methods: Twenty-three patients with severe asthma recruited from a severe asthma clinic were interviewed about the impact of their respiratory symptoms and the burden of their treatment. The domains from a thematic analysis of these interviews were compared with the items of eight asthma-specific HRQoL scales. Results: In addition to the burden caused by symptoms, ten domains of OCS impact on HRQoL were identified: depression, irritability, sleep, hunger, weight, skin, gastric, pain, disease anxiety, and medication anxiety. Some patients experienced substantial HRQoL deficits attributed to OCS. Although all HRQoL scales include some OCS-relevant items, all eight scales fail to adequately assess the several types of burden experienced by some patients while on OCS. Conclusion: The burden of OCS in severe asthma is neglected in policy and practice because it is not assessed in outcome studies. Existing asthma HRQoL scales provide an overly positive estimation of HRQoL in patients with frequent exposure to OCS and underestimate the benefit of interventions that reduce OCS exposure. Changes to existing measurement procedures are needed. Springer International Publishing Switzerland, 2014 Severe asthma nationallicence Difficult asthma nationallicence Quality of life nationallicence Treatment burden nationallicence Assessment nationallicence Hyland Michael School of Psychology, Plymouth University, PL4 8AA, Plymouth, UK aut Whalley Ben School of Psychology, Plymouth University, PL4 8AA, Plymouth, UK aut Jones Rupert Plymouth Respiratory Psychology Partnership, Plymouth, UK aut Masoli Matthew Plymouth Respiratory Psychology Partnership, Plymouth, UK aut Quality of Life Research Springer International Publishing 24/3(2015-03-01), 631-639 0962-9343 24:3<631 2015 24 11136 https://doi.org/10.1007/s11136-014-0801-x text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s11136-014-0801-x text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Hyland Michael School of Psychology, Plymouth University, PL4 8AA, Plymouth, UK aut NATIONALLICENCE 700 1- Whalley Ben School of Psychology, Plymouth University, PL4 8AA, Plymouth, UK aut NATIONALLICENCE 700 1- Jones Rupert Plymouth Respiratory Psychology Partnership, Plymouth, UK aut NATIONALLICENCE 700 1- Masoli Matthew Plymouth Respiratory Psychology Partnership, Plymouth, UK aut NATIONALLICENCE 773 0- Quality of Life Research Springer International Publishing 24/3(2015-03-01), 631-639 0962-9343 24:3<631 2015 24 11136