caa a22 4500 606179224 CHVBK 20210128100800.0 cr unu---uuuuu 210128e20150301xx s 000 0 eng 10.1007/s11136-014-0811-8 doi (NATIONALLICENCE)springer-10.1007/s11136-014-0811-8 The relationship of health-related quality of life and treatment outcome during inpatient treatment of depression [Elektronische Daten] [Stephan Köhler, Theresa Unger, Sabine Hoffmann, Arthur Mackert, Barbara Ross, Thomas Fydrich] Purpose: Health-related quality of life (HRQoL) is important for long-term social functioning. It is considerably reduced in patients with depression. We studied the impact of HRQoL on treatment outcome in patients with unipolar depression. Furthermore, we analysed factors associated with HRQoL in inpatients with unipolar depression. Methods: One hundred and eighty patients suffering from major depressive disorder were evaluated during their inpatient treatment by assessing admission and discharge depression severity and their HRQoL, using the Medical Outcomes Study 12-item Short Form (SF-12). Baseline and treatment variables associated with HRQoL were examined by regression analysis. Primary outcome measures were the Hamilton Rating Scale and theBeck Depression Inventory. Results: HRQoL improved significantly during inpatient treatment. Lower HRQoL outcomes were strongly associated with higher age, somatic comorbidities, a recurrent depressive disorder and stronger depressive symptoms at admission. Additionally, patients with a complex treatment situation (high number of medications, antidepressant switch) showed stronger impairment of HRQoL. Personality disorders and additional psychotherapy did not predict HRQoL. Conclusion: The inpatient treatment resulted in an increase of the SF-12 scores, although to a lower extent than depressive symptoms. Several factors negatively influence HRQoL, such as the presence of somatic and axis I psychiatric comorbiditites and a recurrent or severe depressive episode. Targeting somatic comorbidities in patients with unipolar depression seem to play an important role for HRQoL. Springer International Publishing Switzerland, 2014 Depression nationallicence HRQoL nationallicence Health-related quality of life nationallicence Treatment response nationallicence Inpatient treatment nationallicence Köhler Stephan Department of Psychiatry and Psychotherapy, Kliniken im Theodor-Wenzel-Werk, Berlin, Germany aut Unger Theresa Department of Psychiatry and Psychotherapy, Kliniken im Theodor-Wenzel-Werk, Berlin, Germany aut Hoffmann Sabine Department of Psychiatry and Psychotherapy, Kliniken im Theodor-Wenzel-Werk, Berlin, Germany aut Mackert Arthur Department of Psychiatry and Psychotherapy, Kliniken im Theodor-Wenzel-Werk, Berlin, Germany aut Ross Barbara Department of Psychiatry and Psychotherapy, Kliniken im Theodor-Wenzel-Werk, Berlin, Germany aut Fydrich Thomas Department of Psychology, Humboldt-University, Berlin, Germany aut Quality of Life Research Springer International Publishing 24/3(2015-03-01), 641-649 0962-9343 24:3<641 2015 24 11136 https://doi.org/10.1007/s11136-014-0811-8 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s11136-014-0811-8 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Köhler Stephan Department of Psychiatry and Psychotherapy, Kliniken im Theodor-Wenzel-Werk, Berlin, Germany aut NATIONALLICENCE 700 1- Unger Theresa Department of Psychiatry and Psychotherapy, Kliniken im Theodor-Wenzel-Werk, Berlin, Germany aut NATIONALLICENCE 700 1- Hoffmann Sabine Department of Psychiatry and Psychotherapy, Kliniken im Theodor-Wenzel-Werk, Berlin, Germany aut NATIONALLICENCE 700 1- Mackert Arthur Department of Psychiatry and Psychotherapy, Kliniken im Theodor-Wenzel-Werk, Berlin, Germany aut NATIONALLICENCE 700 1- Ross Barbara Department of Psychiatry and Psychotherapy, Kliniken im Theodor-Wenzel-Werk, Berlin, Germany aut NATIONALLICENCE 700 1- Fydrich Thomas Department of Psychology, Humboldt-University, Berlin, Germany aut NATIONALLICENCE 773 0- Quality of Life Research Springer International Publishing 24/3(2015-03-01), 641-649 0962-9343 24:3<641 2015 24 11136