caa a22 4500 606179313 CHVBK 20210128100800.0 cr unu---uuuuu 210128e20151001xx s 000 0 eng 10.1007/s11136-015-0995-6 doi (NATIONALLICENCE)springer-10.1007/s11136-015-0995-6 The added effect of comorbidity on health-related quality of life in patients with asthma [Elektronische Daten] [Wenjia Chen, Larry Lynd, J. FitzGerald, Carlo Marra, Roxanne Rousseau, Mohsen Sadatsafavi] Purpose: To examine the effect of comorbidities on health-related quality of life (HRQoL) and their interaction with asthma control. Methods: In a random sample of adults with asthma, we measured generic (EQ5D) and disease-specific (AQ5D) utility scores. Asthma symptom control was determined using the 2014 Global Initiative for Asthma Management Strategy. Comorbidity scores were calculated using a validated questionnaire. We used two-part regression models to measure the adjusted difference in utility across levels of symptom control and comorbidity scores and to examine the relative role of symptom control and comorbidity in explaining the variation in HRQoL. Results: A total of 2,299 observations from 460 adult patients (mean age 52years, 67% women) were included. Compared to controlled asthma, uncontrolled asthma was associated with −0.018 reduction (95% CI −0.028, −0.009) in EQ5D and −0.076 reduction (95% CI −0.115, −0.052) in AQ5D utilities. An increase by one standard deviation in comorbidity score relative to the mean was associated with a change of −0.029 (95% CI −0.043, −0.016) in EQ5D and −0.010 (95% CI −0.020, −0.004) in AQLQ utilities. The impact of comorbidity was greater than asthma symptom control in explaining EQ5D variance (12 vs. 1%) but smaller in explaining AQ5D variance (3 vs. 12%). Conclusions: Generic and disease-specific HRQoL instruments differentially capture the impact of symptom control and comorbidity in asthma. The selection of HRQoL instruments for asthma studies should depend on the prevalence of comorbidity in the target population and the impact of interventions on asthma control and comorbidity. Springer International Publishing Switzerland, 2015 Asthma control nationallicence Comorbidity nationallicence Health-related quality of life nationallicence Generic instrument nationallicence Disease-specific instrument nationallicence Utility nationallicence Chen Wenjia Collaboration for Outcomes Research and Evaluation, Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, BC, Canada aut Lynd Larry Collaboration for Outcomes Research and Evaluation, Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, BC, Canada aut FitzGerald J. Division of Respiratory Medicine, Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada aut Marra Carlo Collaboration for Outcomes Research and Evaluation, Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, BC, Canada aut Rousseau Roxanne Division of Respiratory Medicine, Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada aut Sadatsafavi Mohsen Division of Respiratory Medicine, Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada aut Quality of Life Research Springer International Publishing 24/10(2015-10-01), 2507-2517 0962-9343 24:10<2507 2015 24 11136 https://doi.org/10.1007/s11136-015-0995-6 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s11136-015-0995-6 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Chen Wenjia Collaboration for Outcomes Research and Evaluation, Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, BC, Canada aut NATIONALLICENCE 700 1- Lynd Larry Collaboration for Outcomes Research and Evaluation, Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, BC, Canada aut NATIONALLICENCE 700 1- FitzGerald J. Division of Respiratory Medicine, Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada aut NATIONALLICENCE 700 1- Marra Carlo Collaboration for Outcomes Research and Evaluation, Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, BC, Canada aut NATIONALLICENCE 700 1- Rousseau Roxanne Division of Respiratory Medicine, Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada aut NATIONALLICENCE 700 1- Sadatsafavi Mohsen Division of Respiratory Medicine, Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada aut NATIONALLICENCE 773 0- Quality of Life Research Springer International Publishing 24/10(2015-10-01), 2507-2517 0962-9343 24:10<2507 2015 24 11136