caa a22 4500 606179402 CHVBK 20210128100801.0 cr unu---uuuuu 210128e20151001xx s 000 0 eng 10.1007/s11136-015-0985-8 doi (NATIONALLICENCE)springer-10.1007/s11136-015-0985-8 Quality of life changes in patients undergoing treatment for hepatocellular carcinoma [Elektronische Daten] [Wei-Chu Chie, Fang Yu, Mengqian Li, Lorena Baccaglini, Jane Blazeby, Chin-Fu Hsiao, Herng-Chia Chiu, Ronnie Poon, Naoko Mikoshiba, Gillian Al-Kadhimi, Nigel Heaton, Jozer Calara, Peter Collins, Katharine Caddick, Anna Costantini, Valerie Vilgrain, Chieh Chiang] Purpose: Hepatocellular carcinoma (HCC) is the second leading cause of cancer-related death worldwide. One of the primary treatment goals for incurable advanced cases is to prolong quality of life (QoL). Thus, to determine which HCC therapies may be linked to a more favorable QoL, we assessed the association between QoL changes and different treatments in HCC patients. Methods: We analyzed a non-randomized multicenter longitudinal study, which included 171 patients treated with surgery (n=53), ablation (n=53) or embolization (n=65) from seven centers: four Asian and three European sites. All participants completed the EORTC QLQ-C30 and QLQ-HCC18 questionnaires before and after treatment. Propensity scores were calculated and used in addition to race for adjustment in the logistic regression model to account for the confounding effects of patient characteristics including age, gender, race, employment, living with family, at least one comorbid condition, years since diagnosis, prior treatment history, BCLC stage, Child-Pugh grade, cirrhosis, bilirubin levels and QoL score before treatment. Results: After adjustment for confounders, patients tended to have higher odds of QoL deterioration when treated with ablation versus embolization (dyspnea: p=0.019; appetite loss: p=0.018; body image: p=0.035) or ablation versus surgery (dyspnea: p=0.099; appetite loss: p=0.100; body image: p=0.038). Conclusions: There were significant differences in QoL deterioration across different treatment groups. This information may assist patients and providers when selecting patient-centered treatment approaches for HCC. Springer International Publishing Switzerland, 2015 Quality of life nationallicence Asian nationallicence Treatment nationallicence Hepatocellular nationallicence Carcinoma nationallicence Chie Wei-Chu Graduate Institute of Epidemiology and Preventive Medicine, Department of Public Health, College of Public Health, National Taiwan University, Taipei, Taiwan aut Yu Fang Department of Biostatistics, College of Public Health, University of Nebraska Medical Center, Omaha, NE, USA aut Li Mengqian Department of Biostatistics, College of Public Health, University of Nebraska Medical Center, Omaha, NE, USA aut Baccaglini Lorena Department of Epidemiology, College of Public Health, University of Nebraska Medical Center, Omaha, NE, USA aut Blazeby Jane School of Social & Community Medicine, University of Bristol, Bristol, UK aut Hsiao Chin-Fu Division of Clinical Trial Statistics, Institute of Population Health Sciences, National Health Research Institutes, Zhunan, Taiwan aut Chiu Herng-Chia Graduate Institute of Healthcare Administration, Kaohsiung Medical University, Kaohsiung, Taiwan aut Poon Ronnie Department of Surgery, The University of Hong Kong, Queen Mary Hospital, Pok Fu Lam, Hong Kong aut Mikoshiba Naoko Department of Adult Nursing/Palliative Care Nursing, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan aut Al-Kadhimi Gillian Institute of Liver Studies, King's College Hospital, London, UK aut Heaton Nigel Institute of Liver Studies, King's College Hospital, London, UK aut Calara Jozer Institute of Liver Studies, King's College Hospital, London, UK aut Collins Peter Department of Hepatology, University Hospitals Bristol NHS Foundation Trust, Bristol, UK aut Caddick Katharine Department of Hepatology, University Hospitals Bristol NHS Foundation Trust, Bristol, UK aut Costantini Anna Psychooncology Unit, Sant'Andrea Hospital-Faculty of Medicine and Psychology, Sapienza University of Rome, Rome, Italy aut Vilgrain Valerie Department of Radiology, Assistance-Publique Hôpitaux de Paris, APHP, Hôpital Beaujon, Clichy, France aut Chiang Chieh Division of Clinical Trial Statistics, Institute of Population Health Sciences, National Health Research Institutes, Zhunan, Taiwan aut Quality of Life Research Springer International Publishing 24/10(2015-10-01), 2499-2506 0962-9343 24:10<2499 2015 24 11136 https://doi.org/10.1007/s11136-015-0985-8 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s11136-015-0985-8 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Chie Wei-Chu Graduate Institute of Epidemiology and Preventive Medicine, Department of Public Health, College of Public Health, National Taiwan University, Taipei, Taiwan aut NATIONALLICENCE 700 1- Yu Fang Department of Biostatistics, College of Public Health, University of Nebraska Medical Center, Omaha, NE, USA aut NATIONALLICENCE 700 1- Li Mengqian Department of Biostatistics, College of Public Health, University of Nebraska Medical Center, Omaha, NE, USA aut NATIONALLICENCE 700 1- Baccaglini Lorena Department of Epidemiology, College of Public Health, University of Nebraska Medical Center, Omaha, NE, USA aut NATIONALLICENCE 700 1- Blazeby Jane School of Social & Community Medicine, University of Bristol, Bristol, UK aut NATIONALLICENCE 700 1- Hsiao Chin-Fu Division of Clinical Trial Statistics, Institute of Population Health Sciences, National Health Research Institutes, Zhunan, Taiwan aut NATIONALLICENCE 700 1- Chiu Herng-Chia Graduate Institute of Healthcare Administration, Kaohsiung Medical University, Kaohsiung, Taiwan aut NATIONALLICENCE 700 1- Poon Ronnie Department of Surgery, The University of Hong Kong, Queen Mary Hospital, Pok Fu Lam, Hong Kong aut NATIONALLICENCE 700 1- Mikoshiba Naoko Department of Adult Nursing/Palliative Care Nursing, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan aut NATIONALLICENCE 700 1- Al-Kadhimi Gillian Institute of Liver Studies, King's College Hospital, London, UK aut NATIONALLICENCE 700 1- Heaton Nigel Institute of Liver Studies, King's College Hospital, London, UK aut NATIONALLICENCE 700 1- Calara Jozer Institute of Liver Studies, King's College Hospital, London, UK aut NATIONALLICENCE 700 1- Collins Peter Department of Hepatology, University Hospitals Bristol NHS Foundation Trust, Bristol, UK aut NATIONALLICENCE 700 1- Caddick Katharine Department of Hepatology, University Hospitals Bristol NHS Foundation Trust, Bristol, UK aut NATIONALLICENCE 700 1- Costantini Anna Psychooncology Unit, Sant'Andrea Hospital-Faculty of Medicine and Psychology, Sapienza University of Rome, Rome, Italy aut NATIONALLICENCE 700 1- Vilgrain Valerie Department of Radiology, Assistance-Publique Hôpitaux de Paris, APHP, Hôpital Beaujon, Clichy, France aut NATIONALLICENCE 700 1- Chiang Chieh Division of Clinical Trial Statistics, Institute of Population Health Sciences, National Health Research Institutes, Zhunan, Taiwan aut NATIONALLICENCE 773 0- Quality of Life Research Springer International Publishing 24/10(2015-10-01), 2499-2506 0962-9343 24:10<2499 2015 24 11136