caa a22 4500 606179607 CHVBK 20210128100802.0 cr unu---uuuuu 210128e20150401xx s 000 0 eng 10.1007/s11136-014-0818-1 doi (NATIONALLICENCE)springer-10.1007/s11136-014-0818-1 Correlation of PROMIS scales and clinical measures among chronic obstructive pulmonary disease patients with and without exacerbations [Elektronische Daten] [Debra Irwin, Charles Atwood Jr., Ron Hays, Karen Spritzer, Honghu Liu, James Donohue, Nancy Leidy, Susan Yount, Darren DeWalt] Purpose: The Patient-Reported Outcomes Measurement Information System (PROMIS®) initiative was developed to advance the methodology of PROs applicable to chronic diseases. Chronic obstructive pulmonary disease (COPD) is a progressive chronic disease associated with poor health. This study was designed to examine the correlation of PROMIS health-related quality of life (HRQOL) scales and clinical measures among COPD patients. Methods: A cross-sectional analysis was conducted comparing patients who were stable (n=100) with those currently experiencing a COPD exacerbation (n=85). All PROMIS measures for adults available at the time of the study (2008), disease-targeted and other HRQOL instruments, health literacy, percent predicted FEV1, and a 6-min walk distance were assessed when patients were considered clinically stable. Results: Stable COPD patients reported significantly (p≤0.05) better health-related quality of life on PROMIS domains than patients experiencing an exacerbation. PROMIS domain scores were significantly (p≤0.01) correlated with each of legacy measures. Six-min walk scores were most highly correlated with the PROMIS physical function domain scores (r=0.53) followed by the fatigue (r=−0.26), social (r=0.24) and to a lesser extent depression (r=−0.23), and anxiety (r=−0.22) domain scores. Percent predicted FEV1 score was significantly associated with PROMIS physical function scores (r=0.27). Conclusion: This study provides support for the validity of the PROMIS measures in COPD patients. Springer International Publishing Switzerland, 2014 Patient-reported outcomes nationallicence Health-related quality of life nationallicence Chronic obstructive pulmonary disease nationallicence ADL : Activities of daily living nationallicence BMI : Body mass index nationallicence CAT : Computerized adaptive testing nationallicence COPD : Chronic obstructive pulmonary disease nationallicence DSA : Discretionary social activities nationallicence ER : Emergency room nationallicence EXACT-PRO : EXAcerbations of Chronic pulmonary disease Tool—Patient Reported Outcomes nationallicence FACIT : Functional assessment of chronic illness therapy nationallicence FEV1 : Forced expiratory volume in 1s nationallicence GOLD : Global initiative for chronic obstructive lung disease nationallicence HRQOL : Health-related quality of life nationallicence IRB : Institutional Review Board nationallicence IRT : Item response theory nationallicence NIH : National Institutes of Health nationallicence MRC : Medical Research Council Dyspnea Scale nationallicence PRO : Patient Reported Outcomes nationallicence PROMIS : Patient Reported Outcomes Measurement Information System nationallicence PSQI : Pittsburgh Sleep Quality Index nationallicence SGRQ : St. George's Respiratory Questionnaire nationallicence SR : Social roles nationallicence s-TOFLHA : Short test of functional health literacy in adults nationallicence Irwin Debra Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina-Chapel Hill, 27599, Chapel Hill, NC, USA aut Atwood Jr. Charles Division of Pulmonary Medicine, University of Pittsburgh and the Pittsburgh Veterans Affairs Medical Center, Pittsburgh, PA, USA aut Hays Ron Department of Medicine, University of California, Los Angeles, Los Angeles, CA, USA aut Spritzer Karen Department of Medicine, University of California, Los Angeles, Los Angeles, CA, USA aut Liu Honghu Department of Dentistry, University of California, Los Angeles, Los Angeles, CA, USA aut Donohue James Division of Pulmonary Medicine, University of North Carolina School of Medicine-Chapel Hill, Chapel Hill, NC, USA aut Leidy Nancy United Biosource Corporation, Bethesda, MD, USA aut Yount Susan Department of Medical Social Sciences, Northwestern University Feinberg School of Medicine, Chicago, IL, USA aut DeWalt Darren Division of General Medicine and Clinical Epidemiology and the Cecil G. Sheps Center for Health Services Research, University of North Carolina School of Medicine, Chapel Hill, NC, USA aut Quality of Life Research Springer International Publishing 24/4(2015-04-01), 999-1009 0962-9343 24:4<999 2015 24 11136 https://doi.org/10.1007/s11136-014-0818-1 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s11136-014-0818-1 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Irwin Debra Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina-Chapel Hill, 27599, Chapel Hill, NC, USA aut NATIONALLICENCE 700 1- Atwood Jr Charles Division of Pulmonary Medicine, University of Pittsburgh and the Pittsburgh Veterans Affairs Medical Center, Pittsburgh, PA, USA aut NATIONALLICENCE 700 1- Hays Ron Department of Medicine, University of California, Los Angeles, Los Angeles, CA, USA aut NATIONALLICENCE 700 1- Spritzer Karen Department of Medicine, University of California, Los Angeles, Los Angeles, CA, USA aut NATIONALLICENCE 700 1- Liu Honghu Department of Dentistry, University of California, Los Angeles, Los Angeles, CA, USA aut NATIONALLICENCE 700 1- Donohue James Division of Pulmonary Medicine, University of North Carolina School of Medicine-Chapel Hill, Chapel Hill, NC, USA aut NATIONALLICENCE 700 1- Leidy Nancy United Biosource Corporation, Bethesda, MD, USA aut NATIONALLICENCE 700 1- Yount Susan Department of Medical Social Sciences, Northwestern University Feinberg School of Medicine, Chicago, IL, USA aut NATIONALLICENCE 700 1- DeWalt Darren Division of General Medicine and Clinical Epidemiology and the Cecil G. Sheps Center for Health Services Research, University of North Carolina School of Medicine, Chapel Hill, NC, USA aut NATIONALLICENCE 773 0- Quality of Life Research Springer International Publishing 24/4(2015-04-01), 999-1009 0962-9343 24:4<999 2015 24 11136