caa a22 4500 606179747 CHVBK 20210128100802.0 cr unu---uuuuu 210128e20150401xx s 000 0 eng 10.1007/s11136-014-0814-5 doi (NATIONALLICENCE)springer-10.1007/s11136-014-0814-5 Validation of clinical symptom IRT scores for diagnosis and severity assessment of common mental disorders [Elektronische Daten] [Elena Olariu, José-Ignacio Castro-Rodriguez, Pilar Álvarez, Carolina Garnier, Marta Reinoso, Luis Martín-López, Jordi Alonso, Carlos Forero] Purpose: We studied the validity and responsiveness of an item response theory (IRT) scoring method for assessing major depressive episode (MDE) and generalized anxiety disorder (GAD) severity based on direct assessment of DSM-IV-TR symptoms. Methods: Prospective cohort study (baseline, 1-month, 3-months assessments) of patients seeking help for incident or aggravated mood or anxiety symptoms from primary, outpatient and inpatient mental health centers (N=244; 67.81% active cases−100% under psychiatric treatment). The drop-out rate at 3 months was 24.89%. Patients were assessed at each follow-up for presence/absence of DSM-IV symptoms of MDE (nine symptoms) and GAD (eight symptoms). IRT scores for depression (INS-D) and anxiety (INS-G), based on response patterns, were obtained by means of a 2-parameter model. Diagnostic accuracy was assessed with receiver operating characteristic analysis, using a blinded MINI interview as gold standard. Scores' construct validity was compared with external clinician-administered (Hamilton Depression Rating Scale, HRSD; Hamilton Anxiety Rating Scale, HAM-A) and self-reported severity measures (PHQ-9; Beck Anxiety Inventory—Subjective Aspects, BAI-Sub). Responsiveness was analyzed based on the evolution of HRSD and HAM-A scores. Results: Both severity scores showed excellent reliability (INS-D: 0.92; INS-G: 0.93) and yielded high diagnostic accuracy (INS-D: AUC=0.96; INS-G: AUC=0.91) with respect to MINI diagnoses. INS-D and INS-G had higher correlations with clinician-administered measures of the same disorder (INS-D-HRSD: 0.73; INS-G-HAM-A: 0.53) than with self-reported measures (INS-D-PHQ-9: 0.69; INS-G-BAI-Sub: 0.49). Patients who recovered during follow-up showed important decreases in severity (Cohen's d INS-D:−1.38; INS-G: −1.75). About 90% variance of INS-D and INS-G score changes over time was associated with changes in clinical status. Conclusions: INS-D and INS-G are short reliable, valid, and responsive measures that can be used for diagnostic and severity assessment of mood and anxiety disorders in outpatient care. Springer International Publishing Switzerland, 2014 Major depressive disorder nationallicence Generalized anxiety disorder nationallicence Primary care nationallicence Assessment/diagnosis nationallicence Measurement/psychometrics nationallicence Olariu Elena Universitat Pompeu Fabra (UPF), Department of Experimental and Health Sciences, Barcelona, Spain aut Castro-Rodriguez José-Ignacio Universitat Pompeu Fabra (UPF), Department of Experimental and Health Sciences, Barcelona, Spain aut Álvarez Pilar Institut de Neuropsiquiatria i Addiccions, Parc de Salut Mar, Barcelona, Spain aut Garnier Carolina Institut de Neuropsiquiatria i Addiccions, Parc de Salut Mar, Barcelona, Spain aut Reinoso Marta Health Services Research Unit, IMIM-Institut Hospital del Mar d'Investigacions Mèdiques, Carrer del Doctor Aiguader, 88, Edifici PRBB, 08003, Barcelona, Spain aut Martín-López Luis Institut de Neuropsiquiatria i Addiccions, Parc de Salut Mar, Barcelona, Spain aut Alonso Jordi Universitat Pompeu Fabra (UPF), Department of Experimental and Health Sciences, Barcelona, Spain aut Forero Carlos Health Services Research Unit, IMIM-Institut Hospital del Mar d'Investigacions Mèdiques, Carrer del Doctor Aiguader, 88, Edifici PRBB, 08003, Barcelona, Spain aut Quality of Life Research Springer International Publishing 24/4(2015-04-01), 979-992 0962-9343 24:4<979 2015 24 11136 https://doi.org/10.1007/s11136-014-0814-5 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s11136-014-0814-5 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Olariu Elena Universitat Pompeu Fabra (UPF), Department of Experimental and Health Sciences, Barcelona, Spain aut NATIONALLICENCE 700 1- Castro-Rodriguez José-Ignacio Universitat Pompeu Fabra (UPF), Department of Experimental and Health Sciences, Barcelona, Spain aut NATIONALLICENCE 700 1- Álvarez Pilar Institut de Neuropsiquiatria i Addiccions, Parc de Salut Mar, Barcelona, Spain aut NATIONALLICENCE 700 1- Garnier Carolina Institut de Neuropsiquiatria i Addiccions, Parc de Salut Mar, Barcelona, Spain aut NATIONALLICENCE 700 1- Reinoso Marta Health Services Research Unit, IMIM-Institut Hospital del Mar d'Investigacions Mèdiques, Carrer del Doctor Aiguader, 88, Edifici PRBB, 08003, Barcelona, Spain aut NATIONALLICENCE 700 1- Martín-López Luis Institut de Neuropsiquiatria i Addiccions, Parc de Salut Mar, Barcelona, Spain aut NATIONALLICENCE 700 1- Alonso Jordi Universitat Pompeu Fabra (UPF), Department of Experimental and Health Sciences, Barcelona, Spain aut NATIONALLICENCE 700 1- Forero Carlos Health Services Research Unit, IMIM-Institut Hospital del Mar d'Investigacions Mèdiques, Carrer del Doctor Aiguader, 88, Edifici PRBB, 08003, Barcelona, Spain aut NATIONALLICENCE 773 0- Quality of Life Research Springer International Publishing 24/4(2015-04-01), 979-992 0962-9343 24:4<979 2015 24 11136