caa a22 4500 60617981X CHVBK 20210128100803.0 cr unu---uuuuu 210128e20150801xx s 000 0 eng 10.1007/s11136-015-0930-x doi (NATIONALLICENCE)springer-10.1007/s11136-015-0930-x Validity of the 12-item World Health Organization Disability Assessment Schedule 2.0 (WHODAS 2.0) in individuals with Huntington disease (HD) [Elektronische Daten] [Noelle Carlozzi, Anna Kratz, Nancy Downing, Siera Goodnight, Jennifer Miner, Nicholas Migliore, Jane Paulsen] Purpose: The reliability and construct validity of the 12-item World Health Organization Disability Assessment Schedule 2.0 (WHODAS 2.0) were examined in individuals with Huntington disease (HD). Methods: We examined factor structure (confirmatory factor analysis), internal consistency reliability (Cronbach's alpha), floor and ceiling effects, convergent validity (Pearson correlations), and known-groups validity (multivariate analysis). Results: Results of a confirmatory factor analysis replicated the six-factor latent model that reflects the six separate scales within the WHODAS 2.0 (understanding and communicating; getting around; self-care; getting along with others; life activities; participation). Cronbach's alpha for the scale was 0.94, suggesting good internal consistency reliability. The WHODAS demonstrated a ceiling effect for 19.5% of participants; there were no floor effects. There was evidence for convergent validity; the WHODAS demonstrated moderate significant correlations with other general measures of health-related quality of life (HRQOL; i.e., RAND-12, EQ5D). Multivariate analyses indicated that late-stage HD participants indicated poorer HRQOL than both early-stage HD and prodromal HD participants for all HRQOL measures. Conclusions: Findings provide support for both the reliability and validity of the WHODAS 2.0 in individuals with HD. Springer International Publishing Switzerland, 2015 Neuropsychology nationallicence Neuropsychological assessment nationallicence World Health Organization Disability Assessment Schedule 2.0 (WHODAS 2.0) nationallicence Confirmatory factor analysis nationallicence Psychometrics nationallicence Carlozzi Noelle Department of Physical Medicine and Rehabilitation, University of Michigan, North Campus Research Complex, 2800 Plymouth Road, 48109-2800, Ann Arbor, MI, USA aut Kratz Anna Department of Physical Medicine and Rehabilitation, University of Michigan, North Campus Research Complex, 2800 Plymouth Road, 48109-2800, Ann Arbor, MI, USA aut Downing Nancy College of Nursing, The University of Iowa, Iowa City, IA, USA aut Goodnight Siera Department of Physical Medicine and Rehabilitation, University of Michigan, North Campus Research Complex, 2800 Plymouth Road, 48109-2800, Ann Arbor, MI, USA aut Miner Jennifer Department of Physical Medicine and Rehabilitation, University of Michigan, North Campus Research Complex, 2800 Plymouth Road, 48109-2800, Ann Arbor, MI, USA aut Migliore Nicholas Department of Physical Medicine and Rehabilitation, University of Michigan, North Campus Research Complex, 2800 Plymouth Road, 48109-2800, Ann Arbor, MI, USA aut Paulsen Jane Department of Psychiatry, Carver College of Medicine, The University of Iowa, Iowa City, IA, USA aut Quality of Life Research Springer International Publishing 24/8(2015-08-01), 1963-1971 0962-9343 24:8<1963 2015 24 11136 https://doi.org/10.1007/s11136-015-0930-x text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s11136-015-0930-x text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Carlozzi Noelle Department of Physical Medicine and Rehabilitation, University of Michigan, North Campus Research Complex, 2800 Plymouth Road, 48109-2800, Ann Arbor, MI, USA aut NATIONALLICENCE 700 1- Kratz Anna Department of Physical Medicine and Rehabilitation, University of Michigan, North Campus Research Complex, 2800 Plymouth Road, 48109-2800, Ann Arbor, MI, USA aut NATIONALLICENCE 700 1- Downing Nancy College of Nursing, The University of Iowa, Iowa City, IA, USA aut NATIONALLICENCE 700 1- Goodnight Siera Department of Physical Medicine and Rehabilitation, University of Michigan, North Campus Research Complex, 2800 Plymouth Road, 48109-2800, Ann Arbor, MI, USA aut NATIONALLICENCE 700 1- Miner Jennifer Department of Physical Medicine and Rehabilitation, University of Michigan, North Campus Research Complex, 2800 Plymouth Road, 48109-2800, Ann Arbor, MI, USA aut NATIONALLICENCE 700 1- Migliore Nicholas Department of Physical Medicine and Rehabilitation, University of Michigan, North Campus Research Complex, 2800 Plymouth Road, 48109-2800, Ann Arbor, MI, USA aut NATIONALLICENCE 700 1- Paulsen Jane Department of Psychiatry, Carver College of Medicine, The University of Iowa, Iowa City, IA, USA aut NATIONALLICENCE 773 0- Quality of Life Research Springer International Publishing 24/8(2015-08-01), 1963-1971 0962-9343 24:8<1963 2015 24 11136