caa a22 4500 606180036 CHVBK 20210128100804.0 cr unu---uuuuu 210128e20150801xx s 000 0 eng 10.1007/s11136-015-0940-8 doi (NATIONALLICENCE)springer-10.1007/s11136-015-0940-8 Psychometric properties of the Hamilton Depression Rating Scale in multiple sclerosis [Elektronische Daten] [Simona Raimo, Luigi Trojano, Daniele Spitaleri, Vittorio Petretta, Dario Grossi, Gabriella Santangelo] Background: Multiple sclerosis (MS) is frequently associated with depressive symptoms and major depression. Objective: We assessed psychometric properties of the Hamilton Depression Rating Scale (HDRS, 17-item version) for assessing depressive symptomatology in a sample of MS patients. Methods: Seventy patients (aged 43.3±10.3years) completed the HDRS and a thorough clinical and neuropsychological assessment, including diagnosis of major depression according to the established clinical criteria. Results: HDRS was easy to administer and acceptable, and showed fair internal consistency (Cronbach's alpha=0.8). The HDRS showed good convergent validity with respect to neuropsychiatric inventory (NPI) subdomain of depression (r rho=.85) and good divergent validity with respect to remaining NPI subdomains (r rho<.30). Moreover, HDRS's total score correlated moderately with functional disability and apathetic symptomatology, and poorly with general cognitive status. Receiver operating characteristics curve analysis demonstrated that a cutoff >14.5 can identify clinically relevant depressive symptoms with good sensitivity (93%) and specificity (97%) with respect to the diagnosis of major depression. Such a cutoff identified clinically relevant depressive symptoms in 42% of our MS sample, whereas 44.2% patients met established clinical criteria for major depression. Conclusion: The HDRS can be considered as an easy, reliable, and valid tool to assess depressive symptomatology for clinical and research purposes in non-demented MS patients. Springer International Publishing Switzerland, 2015 Multiple sclerosis nationallicence Hamilton depression rating scale nationallicence Validation study and depression nationallicence Raimo Simona Department of Psychology, Second University of Naples, Viale Ellittico, 31, Caserta, Italy aut Trojano Luigi Department of Psychology, Second University of Naples, Viale Ellittico, 31, Caserta, Italy aut Spitaleri Daniele Institute of Neurology San G. Moscati Hospital, Avellino, Italy aut Petretta Vittorio Institute of Neurology San G. Moscati Hospital, Avellino, Italy aut Grossi Dario Department of Psychology, Second University of Naples, Viale Ellittico, 31, Caserta, Italy aut Santangelo Gabriella Department of Psychology, Second University of Naples, Viale Ellittico, 31, Caserta, Italy aut Quality of Life Research Springer International Publishing 24/8(2015-08-01), 1973-1980 0962-9343 24:8<1973 2015 24 11136 https://doi.org/10.1007/s11136-015-0940-8 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s11136-015-0940-8 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Raimo Simona Department of Psychology, Second University of Naples, Viale Ellittico, 31, Caserta, Italy aut NATIONALLICENCE 700 1- Trojano Luigi Department of Psychology, Second University of Naples, Viale Ellittico, 31, Caserta, Italy aut NATIONALLICENCE 700 1- Spitaleri Daniele Institute of Neurology San G. Moscati Hospital, Avellino, Italy aut NATIONALLICENCE 700 1- Petretta Vittorio Institute of Neurology San G. Moscati Hospital, Avellino, Italy aut NATIONALLICENCE 700 1- Grossi Dario Department of Psychology, Second University of Naples, Viale Ellittico, 31, Caserta, Italy aut NATIONALLICENCE 700 1- Santangelo Gabriella Department of Psychology, Second University of Naples, Viale Ellittico, 31, Caserta, Italy aut NATIONALLICENCE 773 0- Quality of Life Research Springer International Publishing 24/8(2015-08-01), 1973-1980 0962-9343 24:8<1973 2015 24 11136