caa a22 4500 606180044 CHVBK 20210128100804.0 cr unu---uuuuu 210128e20150801xx s 000 0 eng 10.1007/s11136-014-0913-3 doi (NATIONALLICENCE)springer-10.1007/s11136-014-0913-3 Conceptual structure of the Taiwan Chinese version of the EORTC QLQ-C30 [Elektronische Daten] [Chi-Cheng Huang, Shih-Hsin Tu, Heng-Hui Lien, Ching-Shui Huang, Pa-Chun Wang, Wei-Chu Chie] Objective: This study aimed to evaluate the conceptual structure of the European Organization for Research and Treatment of Cancer Quality of Life Core Questionnaire 30 (EORTC QLQ-C30) by analyzing data collected from patients with major cancers in Taiwan. The conceptual structure underlying QLQ-C30, including higher-order factors, was explored by structural equation modeling (SEM). Methods: The Taiwan Chinese version of the EORTC QLQ-C30 was used as the measuring instrument. Higher-order models, including mental health/physical health, mental function/physical burden, symptom burden/function, single latent health-related quality of life, formative symptom burden/function, and formative health-related quality of life, were tested. Results: Study subjects included 283 patients with breast, lung, and nasopharyngeal cancers. The original QLQ-C30 multi-factorial structure demonstrated poor composite reliability of the cognitive function subscale. The formative symptom/burden model was favored by model fit indices, further supporting causal-indicator duality, but was compromised by unexpected associations between symptomatic subscales and latent factors. The formative health-related quality of life was proposed with a single second-order latent factor where symptomatic subscales remained formative. Two additional symptom measures from the formal cognitive function subscale with the formative health-related quality-of-life model were proposed as the alterative conceptual structure for the Taiwan Chinese QLQ-C30. Conclusions: Results of the current study represent the complete SEM approach for the EORTC QLQ-C30. The formative health-related quality-of-life model with elimination of cognitive function enhances the conceptual structure of the Taiwan Chinese version with parsimonious fit and interpretability. Springer International Publishing Switzerland, 2015 Quality of life nationallicence EORTC QLQ-C30 nationallicence Taiwan Chinese nationallicence Cancer nationallicence Conceptual structure nationallicence Higher-order factor nationallicence Huang Chi-Cheng Cathay General Hospital SiJhih, New Taipei City, Taiwan aut Tu Shih-Hsin School of Medicine, Taipei Medical University, Taipei City, Taiwan aut Lien Heng-Hui School of Medicine, Fu-Jen Catholic University, New Taipei City, Taiwan aut Huang Ching-Shui School of Medicine, Taipei Medical University, Taipei City, Taiwan aut Wang Pa-Chun Quality Management Center, Cathay General Hospital, Taipei City, Taiwan aut Chie Wei-Chu Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei City, Taiwan aut Quality of Life Research Springer International Publishing 24/8(2015-08-01), 1999-2013 0962-9343 24:8<1999 2015 24 11136 https://doi.org/10.1007/s11136-014-0913-3 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s11136-014-0913-3 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Huang Chi-Cheng Cathay General Hospital SiJhih, New Taipei City, Taiwan aut NATIONALLICENCE 700 1- Tu Shih-Hsin School of Medicine, Taipei Medical University, Taipei City, Taiwan aut NATIONALLICENCE 700 1- Lien Heng-Hui School of Medicine, Fu-Jen Catholic University, New Taipei City, Taiwan aut NATIONALLICENCE 700 1- Huang Ching-Shui School of Medicine, Taipei Medical University, Taipei City, Taiwan aut NATIONALLICENCE 700 1- Wang Pa-Chun Quality Management Center, Cathay General Hospital, Taipei City, Taiwan aut NATIONALLICENCE 700 1- Chie Wei-Chu Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei City, Taiwan aut NATIONALLICENCE 773 0- Quality of Life Research Springer International Publishing 24/8(2015-08-01), 1999-2013 0962-9343 24:8<1999 2015 24 11136