caa a22 4500 606180079 CHVBK 20210128100804.0 cr unu---uuuuu 210128e20150501xx s 000 0 eng 10.1007/s11136-014-0853-y doi (NATIONALLICENCE)springer-10.1007/s11136-014-0853-y Identifying changes in scores on the EORTC-QLQ-C30 representing a change in patients' supportive care needs [Elektronische Daten] [Claire Snyder, Amanda Blackford, Jonathan Sussman, Daryl Bainbridge, Doris Howell, Hsien Seow, Michael Carducci, Albert Wu] Purpose: Using health-related quality-of-life measures for patient management requires knowing what changes in scores require clinical attention. We estimated changes on the European Organization for Research and Treatment of Cancer Quality-of-Life-Questionnaire-Core-30 (EORTC-QLQ-C30), representing important changes by comparing to patient-reported changes in supportive care needs. Methods: This secondary analysis used data from 193 newly diagnosed cancer patients (63% breast, 37% colorectal; mean age 60years; 20% male) from 28 Canadian surgical practices. Participants completed the Supportive Care Needs Survey-Short Form-34 (SCNS-SF34) and EORTC-QLQ-C30 at baseline, 3, and 8weeks. We calculated mean changes in EORTC-QLQ-C30 scores associated with improvement, worsening, and no change in supportive care needs based on the SCNS-SF34. Mean changes in the EORTC-QLQ-C30 scores associated with the SCNS-SF34 improved and worsened categories were used to estimate clinically important changes, and the ‘no change' category to estimate insignificant changes. Results: EORTC-QLQ-C30 score changes ranged from 6 to 32 points for patients reporting improved supportive care needs; statistically significant changes were 10-32 points. EORTC-QLQ-C30 score changes ranged from 21-point worsening to 21-point improvement for patients reporting worsening supportive care needs; statistically significant changes were 9-21 points in the hypothesized direction and a 21-point statistically significant change in the opposite direction. EORTC-QLQ-C30 score changes ranged from a 1-point worsening to 16-point improvement for patients reporting stable supportive care needs. Conclusion: These data suggest 10-point EORTC-QLQ-C30 score changes represent changes in supportive care needs. When using the EORTC-QLQ-C30 in clinical practice, scores changing ≥10 points should be highlighted for clinical attention. Springer International Publishing Switzerland, 2014 EORTC-QLQ-C30 nationallicence Supportive care needs nationallicence Patient-reported outcomes nationallicence Clinical practice nationallicence Cancer nationallicence Clinically important differences nationallicence AUC : Area under the curve nationallicence EORTC-QLQ-C30 : European Organization for the Research and Treatment of Cancer Quality-of-Life-Questionnaire-Core-30 nationallicence GEE : Generalized estimating equation nationallicence HRQOL : Health-related quality of life nationallicence MID : Minimal important difference nationallicence PRO : Patient-reported outcome nationallicence RCT : Randomized controlled trial nationallicence ROC : Receiver operating characteristic nationallicence SCNS-SF34 : Supportive Care Needs Survey-Short Form-34 nationallicence Snyder Claire Division of General Internal Medicine, Johns Hopkins School of Medicine, 624 N. Broadway, Room 649, 21205, Baltimore, MD, USA aut Blackford Amanda Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD, USA aut Sussman Jonathan McMaster University, Hamilton, ON, Canada aut Bainbridge Daryl McMaster University, Hamilton, ON, Canada aut Howell Doris University Health Network/Princess Margaret Hospital, Toronto, ON, Canada aut Seow Hsien McMaster University, Hamilton, ON, Canada aut Carducci Michael Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD, USA aut Wu Albert Division of General Internal Medicine, Johns Hopkins School of Medicine, 624 N. Broadway, Room 649, 21205, Baltimore, MD, USA aut Quality of Life Research Springer International Publishing 24/5(2015-05-01), 1207-1216 0962-9343 24:5<1207 2015 24 11136 https://doi.org/10.1007/s11136-014-0853-y text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s11136-014-0853-y text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Snyder Claire Division of General Internal Medicine, Johns Hopkins School of Medicine, 624 N. Broadway, Room 649, 21205, Baltimore, MD, USA aut NATIONALLICENCE 700 1- Blackford Amanda Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD, USA aut NATIONALLICENCE 700 1- Sussman Jonathan McMaster University, Hamilton, ON, Canada aut NATIONALLICENCE 700 1- Bainbridge Daryl McMaster University, Hamilton, ON, Canada aut NATIONALLICENCE 700 1- Howell Doris University Health Network/Princess Margaret Hospital, Toronto, ON, Canada aut NATIONALLICENCE 700 1- Seow Hsien McMaster University, Hamilton, ON, Canada aut NATIONALLICENCE 700 1- Carducci Michael Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD, USA aut NATIONALLICENCE 700 1- Wu Albert Division of General Internal Medicine, Johns Hopkins School of Medicine, 624 N. Broadway, Room 649, 21205, Baltimore, MD, USA aut NATIONALLICENCE 773 0- Quality of Life Research Springer International Publishing 24/5(2015-05-01), 1207-1216 0962-9343 24:5<1207 2015 24 11136