caa a22 4500 606180087 CHVBK 20210128100804.0 cr unu---uuuuu 210128e20150501xx s 000 0 eng 10.1007/s11136-014-0844-z doi (NATIONALLICENCE)springer-10.1007/s11136-014-0844-z Genetic variations underlying self-reported physical functioning: a review [Elektronische Daten] [Melissa Thong, Mirjam Sprangers, Jeff Sloan, Donald Patrick, Ping Yang, Cornelis van Noorden] Purpose: Genetic associations with self-reported physical functioning (SPF) are less well-studied than genetic associations with performance-measured physical functioning (PPF). We review the literature on the associations of genetic variations on SPF. We provide an overview of SPF assessment, genetic contributions to SPF including heritability, effects of genetic variations and mutations, and effects of interventions on the gene-SPF relationship. We also aim to provide directions for future research. Methods: A computerized literature search using PubMed, Web of Science, and PsychInfo was conducted to select relevant literature published up to November 2013. Inclusion criteria were the use of an SPF questionnaire, original articles in English on human subjects, published in peer-reviewed journals and reporting significant associations between SPF and the genome. Results: Nineteen articles were included. SPF was commonly assessed with the Short Form-36 questionnaire involving mainly convenience samples of either older persons or chronically ill. Heritability estimates were 10-30%. Candidate genes associated with SPF could be ascribed to biological pathways associated with neurodegeneration, physiological systems regulation, or cell regulation. The APOE gene associated with neurodegeneration was most studied (n=3). Three papers included both SPF and PPF assessments. No genome-wide association study on SPF has been conducted. Conclusions: Associations between SPF and the genome have been investigated in selected populations in a limited number of publications. Future research should consider increasing sample variation and incorporate both SPF and PPF assessments. Also, longitudinal studies should be conducted in order to elicit stronger conclusions regarding the genetic associations with SPF. Springer International Publishing Switzerland, 2014 Biological markers nationallicence Genetics nationallicence Health-related quality of life nationallicence Physical functioning nationallicence Self-report nationallicence Thong Melissa CoRPS - Center of Research on Psychology in Somatic Diseases, Tilburg University, P.O. Box 90153, 5000 LE, Tilburg, The Netherlands aut Sprangers Mirjam Department of Medical Psychology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands aut Sloan Jeff Section of Cancer Center Statistics, Division of Biomedical Statistics and Informatics, Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA aut Patrick Donald Department of Health Services, University of Washington, Seattle, WA, USA aut Yang Ping Department of Health Services, University of Washington, Seattle, WA, USA aut van Noorden Cornelis Division of Epidemiology, Department of Health Science Research, Mayo Clinic, Rochester, MN, USA aut Quality of Life Research Springer International Publishing 24/5(2015-05-01), 1163-1177 0962-9343 24:5<1163 2015 24 11136 https://doi.org/10.1007/s11136-014-0844-z text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 review-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s11136-014-0844-z text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Thong Melissa CoRPS - Center of Research on Psychology in Somatic Diseases, Tilburg University, P.O. Box 90153, 5000 LE, Tilburg, The Netherlands aut NATIONALLICENCE 700 1- Sprangers Mirjam Department of Medical Psychology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands aut NATIONALLICENCE 700 1- Sloan Jeff Section of Cancer Center Statistics, Division of Biomedical Statistics and Informatics, Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA aut NATIONALLICENCE 700 1- Patrick Donald Department of Health Services, University of Washington, Seattle, WA, USA aut NATIONALLICENCE 700 1- Yang Ping Department of Health Services, University of Washington, Seattle, WA, USA aut NATIONALLICENCE 700 1- van Noorden Cornelis Division of Epidemiology, Department of Health Science Research, Mayo Clinic, Rochester, MN, USA aut NATIONALLICENCE 773 0- Quality of Life Research Springer International Publishing 24/5(2015-05-01), 1163-1177 0962-9343 24:5<1163 2015 24 11136