caa a22 4500 60618029X CHVBK 20210128100805.0 cr unu---uuuuu 210128e20150501xx s 000 0 eng 10.1007/s11136-014-0851-0 doi (NATIONALLICENCE)springer-10.1007/s11136-014-0851-0 Health-related quality of life in women referred for bone density assessment: relationships with bone mineral density, fracture and co-morbidity [Elektronische Daten] [Sally Wilson, Christopher Sharp, Michael Davie] Purpose: To identify variables that might influence health-related quality of life (HRQoL) in patients with and without a history of fracture, attending bone mineral density (BMD) assessment prior to diagnosis of osteoporosis. Methods: This cross-sectional study included 312 newly referred postmenopausal women attending for a DXA scan, without a diagnosis of osteoporosis. Data were obtained from the medical history and the General Practitioner's letter. HRQoL, using SF36 was scored using published algorithms with reference to an age-related population from England. Regression analyses were used to determine relationships between HRQoL and BMD, age, fracture status and co-morbidities. Results: For all patients, the age-related physical component summary (PCS) and mental component summary (MCS) scores were 46±10 and 47±10, respectively. Controlling for confounding variables, low BMD at the femoral neck was associated with worse PCS scores (p=0.010) and MCS scores (p=0.034) in patients without fracture. In patients with a history of fracture, this relationship was less evident, and younger age (p<0.00), increasing BMI (p=0.016) and number of co-morbidities (p=0.042) were associated with reductions in PCS scores. Conclusions: Patients referred for BMD assessment before a diagnosis of osteoporosis had reduced PCS scores. In patients without fracture, low BMD contributed to this reduction in health-related quality of life. Low PCS scores in patients with fracture were seen only in younger subjects with osteoporosis. Springer International Publishing Switzerland, 2014 Bone density nationallicence Osteoporosis nationallicence Fracture nationallicence HRQoL nationallicence SF36 nationallicence Wilson Sally School of Sport Health and Exercise Sciences, Bangor University, George Building, Holyhead Road, LL57 2PZ, Bangor, Gwynedd, UK aut Sharp Christopher Division of Clinical Chemistry, Department of Clinical and Experimental Medicine, Linköping University, 581 85, Linköping, Sweden aut Davie Michael Bone Health Service, Charles Salt Laboratories, Robert Jones & Agnes Hunt Orthopaedic Hospital NHS Foundation Trust, SY10 7AG, Oswestry, Shropshire, UK aut Quality of Life Research Springer International Publishing 24/5(2015-05-01), 1235-1243 0962-9343 24:5<1235 2015 24 11136 https://doi.org/10.1007/s11136-014-0851-0 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s11136-014-0851-0 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Wilson Sally School of Sport Health and Exercise Sciences, Bangor University, George Building, Holyhead Road, LL57 2PZ, Bangor, Gwynedd, UK aut NATIONALLICENCE 700 1- Sharp Christopher Division of Clinical Chemistry, Department of Clinical and Experimental Medicine, Linköping University, 581 85, Linköping, Sweden aut NATIONALLICENCE 700 1- Davie Michael Bone Health Service, Charles Salt Laboratories, Robert Jones & Agnes Hunt Orthopaedic Hospital NHS Foundation Trust, SY10 7AG, Oswestry, Shropshire, UK aut NATIONALLICENCE 773 0- Quality of Life Research Springer International Publishing 24/5(2015-05-01), 1235-1243 0962-9343 24:5<1235 2015 24 11136