caa a22 4500 606180354 CHVBK 20210128100805.0 cr unu---uuuuu 210128e20150201xx s 000 0 eng 10.1007/s11136-014-0776-7 doi (NATIONALLICENCE)springer-10.1007/s11136-014-0776-7 A qualitative evaluation of the validity of published health utilities and generic health utility measures for capturing health-related quality of life (HRQL) impact of differentiated thyroid cancer (DTC) at different treatment phases [Elektronische Daten] [Katy Gallop, Cicely Kerr, Stacey Simmons, Bryan McIver, Ezra Cohen] Purpose: This study explored the impact of differentiated thyroid cancer (DTC) on health-related quality of life (HRQL) at different treatment phases and evaluated the validity of published DTC utilities and generic health utility measures (EQ-5D and SF-6D) for economic evaluation of treatments for radio-iodine (RAI) refractory DTC. Methods: Focus groups and interviews were conducted with DTC patients grouped by treatment phase. Qualitative thematic analysis was conducted on interview/focus group transcripts. A thematic coding framework was developed to compare experiences between treatment phases and inform development of a conceptual model. Model concepts were mapped to EQ-5D and SF-6D domains/items. Results: Eight focus groups and 11 individual interviews were conducted with 52 DTC patients. Fifty symptoms and HRQL concepts were identified. The impact of DTC and DTC treatment on emotional and cognitive functioning was reported across the treatment phases. The impact on daily activities, mobility, and energy levels was greatest for patients with recurring/persistent or RAI-refractory DTC. Of the 50 concepts, 25 and 27 mapped directly onto domains/items in the EQ-5D and SF-6D, respectively. The SF-6D covered a broader range of DTC impact on emotional/physical problems and daily/social activities than did the EQ-5D. Conclusions: The conceptual model summarizes the wide-ranging impact of DTC and its treatment on patients' HRQL, particularly for those with recurring/persistent or RAI-refractory DTC. Findings suggest that published DTC utilities lack validity for RAI-refractory DTC and that the SF-6D may be more sensitive to HRQL impact of DTC than the EQ-5D. Springer International Publishing Switzerland, 2014 Differentiated thyroid cancer nationallicence Radio-iodine refractory nationallicence Health-related quality of life nationallicence Qualitative methods nationallicence Conceptual model nationallicence Health utility nationallicence Gallop Katy ICON Patient Reported Outcomes, Seacourt Tower, West Way, OX2 0JJ, Oxford, UK aut Kerr Cicely ICON Patient Reported Outcomes, Seacourt Tower, West Way, OX2 0JJ, Oxford, UK aut Simmons Stacey Eisai Inc., 100 Tice Blvd., 07677, Woodcliff Lake, NJ, USA aut McIver Bryan Moffitt Cancer Center, 12902 Magnolia Drive, Tampa, FL, USA aut Cohen Ezra University of California San Diego Moores Cancer Center, 3855 Health Sciences Dr., 92093, La Jolla, CA, USA aut Quality of Life Research Springer International Publishing 24/2(2015-02-01), 325-338 0962-9343 24:2<325 2015 24 11136 https://doi.org/10.1007/s11136-014-0776-7 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s11136-014-0776-7 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Gallop Katy ICON Patient Reported Outcomes, Seacourt Tower, West Way, OX2 0JJ, Oxford, UK aut NATIONALLICENCE 700 1- Kerr Cicely ICON Patient Reported Outcomes, Seacourt Tower, West Way, OX2 0JJ, Oxford, UK aut NATIONALLICENCE 700 1- Simmons Stacey Eisai Inc., 100 Tice Blvd., 07677, Woodcliff Lake, NJ, USA aut NATIONALLICENCE 700 1- McIver Bryan Moffitt Cancer Center, 12902 Magnolia Drive, Tampa, FL, USA aut NATIONALLICENCE 700 1- Cohen Ezra University of California San Diego Moores Cancer Center, 3855 Health Sciences Dr., 92093, La Jolla, CA, USA aut NATIONALLICENCE 773 0- Quality of Life Research Springer International Publishing 24/2(2015-02-01), 325-338 0962-9343 24:2<325 2015 24 11136