caa a22 4500 606180486 CHVBK 20210128100806.0 cr unu---uuuuu 210128e20150201xx s 000 0 eng 10.1007/s11136-014-0781-x doi (NATIONALLICENCE)springer-10.1007/s11136-014-0781-x PedsQL™ Gastrointestinal Symptoms Scales and Gastrointestinal Worry Scales in pediatric patients with functional and organic gastrointestinal diseases in comparison to healthy controls [Elektronische Daten] [James Varni, Cristiane Bendo, Jolanda Denham, Robert Shulman, Mariella Self, Deborah Neigut, Samuel Nurko, Ashish Patel, James Franciosi, Miguel Saps, Alyson Yeckes, Annette Langseder, Shehzad Saeed, John Pohl] Objective: The primary objective was to compare the gastrointestinal (GI) symptoms and worry of pediatric patients with functional GI disorders (FGIDs) and organic GI diseases to healthy controls utilizing the Pediatric Quality of Life Inventory™ (PedsQL™) Gastrointestinal Symptoms and Worry Scales for patient self-reports ages 5-18years and parent proxy-reports for ages 2-18years. The secondary objective was to compare FGIDs and organic GI diseases to each other. Methods: The PedsQL™ Gastrointestinal Symptoms and Worry Scales were completed in a 9-site study by 587 pediatric patients with GI disorders and 685 parents of patients. Patients had physician-diagnosed GI disorders (chronic constipation, functional abdominal pain, irritable bowel syndrome, functional dyspepsia, Crohn's disease, ulcerative colitis, and gastroesophageal reflux disease). Ten Gastrointestinal Symptoms Scales measuring Stomach Pain, Stomach Discomfort When Eating, Food and Drink Limits, Trouble Swallowing, Heartburn and Reflux, Nausea and Vomiting, Gas and Bloating, Constipation, Blood, and Diarrhea were administered along with two Gastrointestinal Worry Scales. Five hundred and thirteen healthy children and 337 parents of healthy children completed the PedsQL™ Gastrointestinal Scales in an Internet panel survey. Results: The PedsQL™ Gastrointestinal Symptoms and Worry Scales distinguished between pediatric patients with FGIDs and organic GI diseases in comparison with healthy controls, supporting known-groups validity. Patients with FGIDs reported more GI symptoms and worry than patients with organic GI diseases. Conclusions: The PedsQL™ Gastrointestinal Symptoms and Worry Scales may be utilized as common metrics across pediatric patient groups with FGIDs and organic GI diseases and healthy samples to measure GI-specific symptoms in clinical research and practice. Springer International Publishing Switzerland, 2014 PedsQL nationallicence Gastrointestinal nationallicence Gastroenterology nationallicence Symptoms nationallicence Pediatrics nationallicence Patient-reported outcomes nationallicence Health-related quality of life nationallicence PedsQL™ : Pediatric Quality of Life Inventory™ nationallicence FDA : Food and Drug Administration nationallicence HRQOL : Health-related quality of life nationallicence GI : Gastrointestinal nationallicence FGIDs : Functional gastrointestinal disorders nationallicence PRO : Patient-reported outcome nationallicence Varni James Department of Pediatrics, College of Medicine, Texas A&M University, College Station, TX, USA aut Bendo Cristiane Department of Pediatric Dentistry and Orthodontics, Faculty of Dentistry, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil aut Denham Jolanda Division of Pediatric Gastroenterology, Nationwide Children's Hospital, Ohio State University School of Medicine, Columbus, OH, USA aut Shulman Robert Department of Pediatrics, Baylor College of Medicine, Children's Nutrition Research Center, Texas Children's Hospital, Houston, TX, USA aut Self Mariella Departments of Psychiatry and Pediatrics, Baylor College of Medicine, Texas Children's Hospital, Houston, TX, USA aut Neigut Deborah Division of Gastroenterology, Hepatology and Nutrition, Children's Hospital Colorado, Aurora, CO, USA aut Nurko Samuel Center for Motility and Functional Gastrointestinal Disorders, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA aut Patel Ashish Division of Pediatric Gastroenterology, Children's Medical Center of Dallas, University of Texas Southwestern Medical School, Dallas, TX, USA aut Franciosi James Division of Gastroenterology, Hepatology and Nutrition, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA aut Saps Miguel Division of Gastroenterology, Hepatology and Nutrition, Lurie Children's Hospital of Chicago, Northwestern University Feinberg School of Medicine, Chicago, IL, USA aut Yeckes Alyson Division of Gastroenterology, Hepatology and Nutrition, Children's Hospital Colorado, Aurora, CO, USA aut Langseder Annette Division of Pediatric Gastroenterology, Hepatology and Nutrition, Goryeb Children's Hospital, Morristown Medical Center, Morristown, NJ, USA aut Saeed Shehzad Division of Gastroenterology, Hepatology and Nutrition, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA aut Pohl John Department of Pediatric Gastroenterology, Primary Children's Hospital, University of Utah, Salt Lake City, UT, USA aut Quality of Life Research Springer International Publishing 24/2(2015-02-01), 363-378 0962-9343 24:2<363 2015 24 11136 https://doi.org/10.1007/s11136-014-0781-x text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s11136-014-0781-x text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Varni James Department of Pediatrics, College of Medicine, Texas A&M University, College Station, TX, USA aut NATIONALLICENCE 700 1- Bendo Cristiane Department of Pediatric Dentistry and Orthodontics, Faculty of Dentistry, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil aut NATIONALLICENCE 700 1- Denham Jolanda Division of Pediatric Gastroenterology, Nationwide Children's Hospital, Ohio State University School of Medicine, Columbus, OH, USA aut NATIONALLICENCE 700 1- Shulman Robert Department of Pediatrics, Baylor College of Medicine, Children's Nutrition Research Center, Texas Children's Hospital, Houston, TX, USA aut NATIONALLICENCE 700 1- Self Mariella Departments of Psychiatry and Pediatrics, Baylor College of Medicine, Texas Children's Hospital, Houston, TX, USA aut NATIONALLICENCE 700 1- Neigut Deborah Division of Gastroenterology, Hepatology and Nutrition, Children's Hospital Colorado, Aurora, CO, USA aut NATIONALLICENCE 700 1- Nurko Samuel Center for Motility and Functional Gastrointestinal Disorders, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA aut NATIONALLICENCE 700 1- Patel Ashish Division of Pediatric Gastroenterology, Children's Medical Center of Dallas, University of Texas Southwestern Medical School, Dallas, TX, USA aut NATIONALLICENCE 700 1- Franciosi James Division of Gastroenterology, Hepatology and Nutrition, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA aut NATIONALLICENCE 700 1- Saps Miguel Division of Gastroenterology, Hepatology and Nutrition, Lurie Children's Hospital of Chicago, Northwestern University Feinberg School of Medicine, Chicago, IL, USA aut NATIONALLICENCE 700 1- Yeckes Alyson Division of Gastroenterology, Hepatology and Nutrition, Children's Hospital Colorado, Aurora, CO, USA aut NATIONALLICENCE 700 1- Langseder Annette Division of Pediatric Gastroenterology, Hepatology and Nutrition, Goryeb Children's Hospital, Morristown Medical Center, Morristown, NJ, USA aut NATIONALLICENCE 700 1- Saeed Shehzad Division of Gastroenterology, Hepatology and Nutrition, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA aut NATIONALLICENCE 700 1- Pohl John Department of Pediatric Gastroenterology, Primary Children's Hospital, University of Utah, Salt Lake City, UT, USA aut NATIONALLICENCE 773 0- Quality of Life Research Springer International Publishing 24/2(2015-02-01), 363-378 0962-9343 24:2<363 2015 24 11136