caa a22 4500 606180613 CHVBK 20210128100807.0 cr unu---uuuuu 210128e20151101xx s 000 0 eng 10.1007/s11136-015-1005-8 doi (NATIONALLICENCE)springer-10.1007/s11136-015-1005-8 Complex coevolution of depression and health-related quality of life in old age [Elektronische Daten] [André Hajek, Christian Brettschneider, Annette Ernst, Carolin Lange, Birgitt Wiese, Jana Prokein, Siegfried Weyerer, Jochen Werle, Michael Pentzek, Angela Fuchs, Janine Stein, Horst Bickel, Edelgard Mösch, Kathrin Heser, Frank Jessen, Wolfgang Maier, Martin Scherer, Steffi Riedel-Heller, Hans-Helmut König] Purpose: To investigate the coevolution of depression and health-related quality of life (HRQoL) in old age. Methods: In a representative survey of the German general population aged 75years and older, the course of HRQoL and depression was observed over 4.5years (3 waves). HRQoL was assessed by the Visual Analogue Scale (EQ VAS) of the EQ-5D instrument, while the Geriatric Depression Scale was used to measure depression. A panel vector autoregressive model was used to account for the complex coevolution of depression and HRQoL. Unobserved heterogeneity was taken into account by taking the first differences. Results: We revealed a robust negative association between an initial change in HRQoL and a subsequent change in depression score, with substantial sex differences: In women there was a robust association, while in men the significance of this association depended on the model specification. Surprisingly, in the total sample and in both sexes, no robust association between an initial increase in depression and a subsequent change in HRQoL was found. Conclusion: Findings indicate that the direction of evolution from HRQoL to depression deserves more attention. Furthermore, treatment of depression in late life should aim at improving HRQoL in which remission of depressive symptoms is necessary but not sufficient. Springer International Publishing Switzerland, 2015 Health-related quality of life nationallicence Depression nationallicence Depressive symptoms nationallicence Vector autoregressive model nationallicence Older people nationallicence Longitudinal studies nationallicence Hajek André Department of Health Economics and Health Services Research, Hamburg Center for Health Economics, University Medical Center Hamburg-Eppendorf, Martinistr. 52, 20246, Hamburg, Germany aut Brettschneider Christian Department of Health Economics and Health Services Research, Hamburg Center for Health Economics, University Medical Center Hamburg-Eppendorf, Martinistr. 52, 20246, Hamburg, Germany aut Ernst Annette Department of Primary Medical Care, Center for Psychosocial Medicine, University Medical Center Hamburg-Eppendorf, Martinistr. 52, 20246, Hamburg, Germany aut Lange Carolin Department of Primary Medical Care, Center for Psychosocial Medicine, University Medical Center Hamburg-Eppendorf, Martinistr. 52, 20246, Hamburg, Germany aut Wiese Birgitt Institute of General Practice, Hannover Medical School, Carl-Neuberg-Str. 1, 30625, Hannover, Germany aut Prokein Jana Institute of General Practice, Hannover Medical School, Carl-Neuberg-Str. 1, 30625, Hannover, Germany aut Weyerer Siegfried Central Institute of Mental Health, Medical Faculty Mannheim/Heidelberg University, J5, 68159, Mannheim, Germany aut Werle Jochen Central Institute of Mental Health, Medical Faculty Mannheim/Heidelberg University, J5, 68159, Mannheim, Germany aut Pentzek Michael Institute of General Practice, Medical Faculty, Heinrich-Heine-University Düsseldorf, Moorenstr. 5, 40225, Düsseldorf, Germany aut Fuchs Angela Institute of General Practice, Medical Faculty, Heinrich-Heine-University Düsseldorf, Moorenstr. 5, 40225, Düsseldorf, Germany aut Stein Janine Institute of Social Medicine, Occupational Health and Public Health, University of Leipzig, Ph.-Rosenthal-Str. 55, 04103, Leipzig, Germany aut Bickel Horst Department of Psychiatry, Technical University of Munich, Arcisstr. 21, 80333, Munich, Germany aut Mösch Edelgard Department of Psychiatry, Technical University of Munich, Arcisstr. 21, 80333, Munich, Germany aut Heser Kathrin Department of Psychiatry, University of Bonn, Sigmund-Freud-Str. 25, 53127, Bonn, Germany aut Jessen Frank Department of Psychiatry and Psychotherapy, University of Cologne, Kerpener Strasse 62, 50924, Cologne, Germany aut Maier Wolfgang Department of Psychiatry, University of Bonn, Sigmund-Freud-Str. 25, 53127, Bonn, Germany aut Scherer Martin Department of Primary Medical Care, Center for Psychosocial Medicine, University Medical Center Hamburg-Eppendorf, Martinistr. 52, 20246, Hamburg, Germany aut Riedel-Heller Steffi Institute of Social Medicine, Occupational Health and Public Health, University of Leipzig, Ph.-Rosenthal-Str. 55, 04103, Leipzig, Germany aut König Hans-Helmut Department of Health Economics and Health Services Research, Hamburg Center for Health Economics, University Medical Center Hamburg-Eppendorf, Martinistr. 52, 20246, Hamburg, Germany aut Quality of Life Research Springer International Publishing 24/11(2015-11-01), 2713-2722 0962-9343 24:11<2713 2015 24 11136 https://doi.org/10.1007/s11136-015-1005-8 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s11136-015-1005-8 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Hajek André Department of Health Economics and Health Services Research, Hamburg Center for Health Economics, University Medical Center Hamburg-Eppendorf, Martinistr. 52, 20246, Hamburg, Germany aut NATIONALLICENCE 700 1- Brettschneider Christian Department of Health Economics and Health Services Research, Hamburg Center for Health Economics, University Medical Center Hamburg-Eppendorf, Martinistr. 52, 20246, Hamburg, Germany aut NATIONALLICENCE 700 1- Ernst Annette Department of Primary Medical Care, Center for Psychosocial Medicine, University Medical Center Hamburg-Eppendorf, Martinistr. 52, 20246, Hamburg, Germany aut NATIONALLICENCE 700 1- Lange Carolin Department of Primary Medical Care, Center for Psychosocial Medicine, University Medical Center Hamburg-Eppendorf, Martinistr. 52, 20246, Hamburg, Germany aut NATIONALLICENCE 700 1- Wiese Birgitt Institute of General Practice, Hannover Medical School, Carl-Neuberg-Str. 1, 30625, Hannover, Germany aut NATIONALLICENCE 700 1- Prokein Jana Institute of General Practice, Hannover Medical School, Carl-Neuberg-Str. 1, 30625, Hannover, Germany aut NATIONALLICENCE 700 1- Weyerer Siegfried Central Institute of Mental Health, Medical Faculty Mannheim/Heidelberg University, J5, 68159, Mannheim, Germany aut NATIONALLICENCE 700 1- Werle Jochen Central Institute of Mental Health, Medical Faculty Mannheim/Heidelberg University, J5, 68159, Mannheim, Germany aut NATIONALLICENCE 700 1- Pentzek Michael Institute of General Practice, Medical Faculty, Heinrich-Heine-University Düsseldorf, Moorenstr. 5, 40225, Düsseldorf, Germany aut NATIONALLICENCE 700 1- Fuchs Angela Institute of General Practice, Medical Faculty, Heinrich-Heine-University Düsseldorf, Moorenstr. 5, 40225, Düsseldorf, Germany aut NATIONALLICENCE 700 1- Stein Janine Institute of Social Medicine, Occupational Health and Public Health, University of Leipzig, Ph.-Rosenthal-Str. 55, 04103, Leipzig, Germany aut NATIONALLICENCE 700 1- Bickel Horst Department of Psychiatry, Technical University of Munich, Arcisstr. 21, 80333, Munich, Germany aut NATIONALLICENCE 700 1- Mösch Edelgard Department of Psychiatry, Technical University of Munich, Arcisstr. 21, 80333, Munich, Germany aut NATIONALLICENCE 700 1- Heser Kathrin Department of Psychiatry, University of Bonn, Sigmund-Freud-Str. 25, 53127, Bonn, Germany aut NATIONALLICENCE 700 1- Jessen Frank Department of Psychiatry and Psychotherapy, University of Cologne, Kerpener Strasse 62, 50924, Cologne, Germany aut NATIONALLICENCE 700 1- Maier Wolfgang Department of Psychiatry, University of Bonn, Sigmund-Freud-Str. 25, 53127, Bonn, Germany aut NATIONALLICENCE 700 1- Scherer Martin Department of Primary Medical Care, Center for Psychosocial Medicine, University Medical Center Hamburg-Eppendorf, Martinistr. 52, 20246, Hamburg, Germany aut NATIONALLICENCE 700 1- Riedel-Heller Steffi Institute of Social Medicine, Occupational Health and Public Health, University of Leipzig, Ph.-Rosenthal-Str. 55, 04103, Leipzig, Germany aut NATIONALLICENCE 700 1- König Hans-Helmut Department of Health Economics and Health Services Research, Hamburg Center for Health Economics, University Medical Center Hamburg-Eppendorf, Martinistr. 52, 20246, Hamburg, Germany aut NATIONALLICENCE 773 0- Quality of Life Research Springer International Publishing 24/11(2015-11-01), 2713-2722 0962-9343 24:11<2713 2015 24 11136