caa a22 4500 606180796 CHVBK 20210128100808.0 cr unu---uuuuu 210128e20151101xx s 000 0 eng 10.1007/s11136-015-1000-0 doi (NATIONALLICENCE)springer-10.1007/s11136-015-1000-0 Fatigue trajectories during the first 8months after breast cancer diagnosis [Elektronische Daten] [Hanne Bødtcher, Pernille Bidstrup, Ingelise Andersen, Jane Christensen, Birgitte Mertz, Christoffer Johansen, Susanne Dalton] Purpose: The objective of this study was to identify distinct groups of fatigue trajectories among women with breast cancer and to evaluate whether age, anxiety symptoms, physical activity, and type of treatment were associated with belonging to the most adverse fatigue group. Methods: Women scheduled for breast cancer surgery at Copenhagen University Hospital, Denmark, were consecutively invited to participate in the study (n=424), resulting in 290 women included in the analyses. Semiparametric group-based mixture modeling was used to identify distinct trajectories of fatigue assessed the week before surgery and 4 and 8months later. Logistic regression analysis was used to evaluate differences in the distinct fatigue groups. Results: Two distinct groups of fatigue trajectories were identified. One group (21%) had a high mean level, while the second group (79%) had a low mean level of fatigue throughout the study. In multivariate analyses, sedentary physical activity (OR 5.78; 95% CI 1.41-23.75), low physical activity (OR 3.17; 95% CI 1.15-8.74), and increasing anxiety symptoms (OR 1.23; 95% CI 1.14-1.33) before surgery were significantly associated with being in the high-fatigue group. Conclusions: The results show that one-fifth of women with breast cancer experience continuously high fatigue up to 8months after surgery and may have been more anxious and physically inactive. This knowledge is important in targeting interventions to women with fatigue throughout their treatment and who do not return to a low fatigue level with existing treatment, self-management, or support. Springer International Publishing Switzerland, 2015 Fatigue nationallicence Breast cancer nationallicence Semiparametric group-based mixture modeling nationallicence Anxiety symptoms nationallicence Physical activity nationallicence Bødtcher Hanne Survivorship Unit, Danish Cancer Society Research Center, Strandboulevarden 49, 2100, Copenhagen, Denmark aut Bidstrup Pernille Survivorship Unit, Danish Cancer Society Research Center, Strandboulevarden 49, 2100, Copenhagen, Denmark aut Andersen Ingelise Department of Social Medicine, Institute of Public Health, University of Copenhagen, Copenhagen, Denmark aut Christensen Jane Statistics, Bioinformatics and Registry, Danish Cancer Society Research Center, Copenhagen, Denmark aut Mertz Birgitte Breast Surgery Clinic, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark aut Johansen Christoffer Survivorship Unit, Danish Cancer Society Research Center, Strandboulevarden 49, 2100, Copenhagen, Denmark aut Dalton Susanne Survivorship Unit, Danish Cancer Society Research Center, Strandboulevarden 49, 2100, Copenhagen, Denmark aut Quality of Life Research Springer International Publishing 24/11(2015-11-01), 2671-2679 0962-9343 24:11<2671 2015 24 11136 https://doi.org/10.1007/s11136-015-1000-0 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s11136-015-1000-0 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Bødtcher Hanne Survivorship Unit, Danish Cancer Society Research Center, Strandboulevarden 49, 2100, Copenhagen, Denmark aut NATIONALLICENCE 700 1- Bidstrup Pernille Survivorship Unit, Danish Cancer Society Research Center, Strandboulevarden 49, 2100, Copenhagen, Denmark aut NATIONALLICENCE 700 1- Andersen Ingelise Department of Social Medicine, Institute of Public Health, University of Copenhagen, Copenhagen, Denmark aut NATIONALLICENCE 700 1- Christensen Jane Statistics, Bioinformatics and Registry, Danish Cancer Society Research Center, Copenhagen, Denmark aut NATIONALLICENCE 700 1- Mertz Birgitte Breast Surgery Clinic, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark aut NATIONALLICENCE 700 1- Johansen Christoffer Survivorship Unit, Danish Cancer Society Research Center, Strandboulevarden 49, 2100, Copenhagen, Denmark aut NATIONALLICENCE 700 1- Dalton Susanne Survivorship Unit, Danish Cancer Society Research Center, Strandboulevarden 49, 2100, Copenhagen, Denmark aut NATIONALLICENCE 773 0- Quality of Life Research Springer International Publishing 24/11(2015-11-01), 2671-2679 0962-9343 24:11<2671 2015 24 11136