caa a22 4500 606180990 CHVBK 20210128100809.0 cr unu---uuuuu 210128e20150101xx s 000 0 eng 10.1007/s10876-014-0786-1 doi (NATIONALLICENCE)springer-10.1007/s10876-014-0786-1 New Tungsten Cluster Based Contrast Agents for X-ray Computed Tomography [Elektronische Daten] [Detlev Sülzle, Marcus Bauser, Thomas Frenzel, Gregor Jost, Hubertus Pietsch, Martina Schäfer, Markus Berger, Jorma Hassfeld, Heribert Schmitt-Willich] In recognition of the seminal contributions of F. A. Cotton and A. Bino to the field of aqueous chemistry of organometallic, trinuclear cluster compounds of tungsten, we describe their modifications and use as contrast agents for X-ray computed tomography. To enable their fundamental work for an advantageous diagnostic application in medicine a new generation of polydentate W3O2 complexes with improved hydrolytical stability has been synthesized and characterized. The applicability as new metal based contrast agent has been demonstrated in a computed tomography angiography animal study with increased signal intensity. Especially the bis tridentate W3O2 complexes with their reduced stereochemical complexity represent a promising new class in the field of X-ray contrast agents. Springer Science+Business Media New York, 2014 Tungsten nationallicence X-ray contrast agent nationallicence Regio isomers nationallicence W3O2 complexes nationallicence Ligand design nationallicence Sülzle Detlev Global Drug Discovery, Bayer Pharma AG, 13342, Berlin, Germany aut Bauser Marcus Global Drug Discovery, Bayer Pharma AG, 13342, Berlin, Germany aut Frenzel Thomas Global Drug Discovery, Bayer Pharma AG, 13342, Berlin, Germany aut Jost Gregor Global Drug Discovery, Bayer Pharma AG, 13342, Berlin, Germany aut Pietsch Hubertus Global Drug Discovery, Bayer Pharma AG, 13342, Berlin, Germany aut Schäfer Martina Global Drug Discovery, Bayer Pharma AG, 13342, Berlin, Germany aut Berger Markus Global Drug Discovery, Bayer Pharma AG, 13342, Berlin, Germany aut Hassfeld Jorma Global Chemical Development, Bayer Pharma AG, 42096, Wuppertal, Germany aut Schmitt-Willich Heribert Piramal Imaging GmbH, Tegeler Str. 6-7, 13353, Berlin, Germany aut Journal of Cluster Science Springer US; http://www.springer-ny.com 26/1(2015-01-01), 111-118 1040-7278 26:1<111 2015 26 10876 https://doi.org/10.1007/s10876-014-0786-1 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10876-014-0786-1 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Sülzle Detlev Global Drug Discovery, Bayer Pharma AG, 13342, Berlin, Germany aut NATIONALLICENCE 700 1- Bauser Marcus Global Drug Discovery, Bayer Pharma AG, 13342, Berlin, Germany aut NATIONALLICENCE 700 1- Frenzel Thomas Global Drug Discovery, Bayer Pharma AG, 13342, Berlin, Germany aut NATIONALLICENCE 700 1- Jost Gregor Global Drug Discovery, Bayer Pharma AG, 13342, Berlin, Germany aut NATIONALLICENCE 700 1- Pietsch Hubertus Global Drug Discovery, Bayer Pharma AG, 13342, Berlin, Germany aut NATIONALLICENCE 700 1- Schäfer Martina Global Drug Discovery, Bayer Pharma AG, 13342, Berlin, Germany aut NATIONALLICENCE 700 1- Berger Markus Global Drug Discovery, Bayer Pharma AG, 13342, Berlin, Germany aut NATIONALLICENCE 700 1- Hassfeld Jorma Global Chemical Development, Bayer Pharma AG, 42096, Wuppertal, Germany aut NATIONALLICENCE 700 1- Schmitt-Willich Heribert Piramal Imaging GmbH, Tegeler Str. 6-7, 13353, Berlin, Germany aut NATIONALLICENCE 773 0- Journal of Cluster Science Springer US; http://www.springer-ny.com 26/1(2015-01-01), 111-118 1040-7278 26:1<111 2015 26 10876