caa a22 4500 606181059 CHVBK 20210128100809.0 cr unu---uuuuu 210128e20151101xx s 000 0 eng 10.1007/s10876-015-0908-4 doi (NATIONALLICENCE)springer-10.1007/s10876-015-0908-4 Effect of Formulation and Processing Variables on Dexamethasone Entrapment and Release of Niosomes [Elektronische Daten] [Mohammad Mavaddati, Fathollah Moztarzadeh, Fatemeh Baghbani] Multilamellar niosomes entrapping Dexamethasone (Dex) were prepared by thin film hydration, sonication, respectively. The influence of different processing variables (sonication time, temperature) and formulation variable (cholesterol content) on Dex entrapment efficiency % (EE) was demonstrated. Also, the Dex release from the prepared niosomes in phosphate buffer (pH 7.4) was illustrated. Results indicated that cholesterol increased or decreased the noisome size and EE % depending on its concentration within the formulae. The maximum loading efficiency was 29.2% when the span 60:cholesterol molar ratio was 100:50 and the hydrating step was conducted by 30min sonication. Increasing sonication time also increased and then decreased the EE% of Dex into niosomes. Finally, results indicated that in vitro release profiles of Dex from all niosome formulations is an apparently biphasic release process and 5-15% of drug released from niosomes after 8h incubation in buffer, depending on the type of niosome. Springer Science+Business Media New York, 2015 Niosome nationallicence Cholesterol nationallicence Sonication nationallicence Dexamethasone nationallicence Mavaddati Mohammad Institute of Inorganic Chemistry II, Ulm University, Ulm, Germany aut Moztarzadeh Fathollah Biomaterials Group, Faculty of Biomedical Engineering (Center of Excellence), Amirkabir University of Technology, P.O Box 15875-4413, Tehran, Iran aut Baghbani Fatemeh Biomaterials Group, Faculty of Biomedical Engineering (Center of Excellence), Amirkabir University of Technology, P.O Box 15875-4413, Tehran, Iran aut Journal of Cluster Science Springer US; http://www.springer-ny.com 26/6(2015-11-01), 2065-2078 1040-7278 26:6<2065 2015 26 10876 https://doi.org/10.1007/s10876-015-0908-4 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10876-015-0908-4 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Mavaddati Mohammad Institute of Inorganic Chemistry II, Ulm University, Ulm, Germany aut NATIONALLICENCE 700 1- Moztarzadeh Fathollah Biomaterials Group, Faculty of Biomedical Engineering (Center of Excellence), Amirkabir University of Technology, P.O Box 15875-4413, Tehran, Iran aut NATIONALLICENCE 700 1- Baghbani Fatemeh Biomaterials Group, Faculty of Biomedical Engineering (Center of Excellence), Amirkabir University of Technology, P.O Box 15875-4413, Tehran, Iran aut NATIONALLICENCE 773 0- Journal of Cluster Science Springer US; http://www.springer-ny.com 26/6(2015-11-01), 2065-2078 1040-7278 26:6<2065 2015 26 10876