caa a22 4500 606181512 CHVBK 20210128100811.0 cr unu---uuuuu 210128e20150701xx s 000 0 eng 10.1007/s10876-014-0798-x doi (NATIONALLICENCE)springer-10.1007/s10876-014-0798-x Water Soluble Melanin of Streptomyces lusitanus DMZ3 Persuade Synthesis of Enhanced Bio-medically Active Silver Nanoparticles [Elektronische Daten] [D. Madhusudhan, Dayanand Agsar, M. Sulochana] Enhanced bio-medically active silver nanoparticles were produced from water soluble melanin of Streptomyces lusitanus DMZ3. Synthesis of silver nanoparticles within 80s was facilitated by microwave radiation. Melanin silver nanoparticles produced in the range of 13-22nm sizes were confirmed and characterized by UV-Vis spectrum, transmission electron microscopy, dynamic light scattering, X-ray diffraction and Fourier transform infrared spectroscopy analysis. Silver nanoparticles produced from water soluble melanin showed potential biomedical attributes. Promising antioxidant activity of melanin silver nanoparticles with 130µg/mL IC50 (50% inhibition concentration) and 82.5µg/mL EC50 (50% effective concentration) functional potentials were recorded following DPPH (2,2′diphenyl-1-picryldrazyl) method and phosphomolybdate assay respectively. These melanin silver nanoparticles were found to be potential cytotoxic agent with 0.34µg/mL LC50 (50% lethal concentration) employing brine shrimps. Water soluble melanin, explored in the study, naturally would be a strategic biological reducing agent to produce melanin silver nanoparticles with greater biomedical activities. Springer Science+Business Media New York, 2014 Streptomyces nationallicence Soluble melanin nationallicence Microwave radiation nationallicence Silver nanoparticles nationallicence Bio-medical attributes nationallicence Madhusudhan D. A-DBT Research Laboratory, Department of Microbiology, Gulbarga University, 585 106, Gulbarga, India aut Agsar Dayanand A-DBT Research Laboratory, Department of Microbiology, Gulbarga University, 585 106, Gulbarga, India aut Sulochana M. Department of Biotechnology, Gulbarga University, 585 106, Gulbarga, India aut Journal of Cluster Science Springer US; http://www.springer-ny.com 26/4(2015-07-01), 1077-1089 1040-7278 26:4<1077 2015 26 10876 https://doi.org/10.1007/s10876-014-0798-x text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10876-014-0798-x text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Madhusudhan D. A-DBT Research Laboratory, Department of Microbiology, Gulbarga University, 585 106, Gulbarga, India aut NATIONALLICENCE 700 1- Agsar Dayanand A-DBT Research Laboratory, Department of Microbiology, Gulbarga University, 585 106, Gulbarga, India aut NATIONALLICENCE 700 1- Sulochana M. Department of Biotechnology, Gulbarga University, 585 106, Gulbarga, India aut NATIONALLICENCE 773 0- Journal of Cluster Science Springer US; http://www.springer-ny.com 26/4(2015-07-01), 1077-1089 1040-7278 26:4<1077 2015 26 10876