caa a22 4500 60618239X CHVBK 20210128100815.0 cr unu---uuuuu 210128e20150101xx s 000 0 eng 10.1007/s00405-014-2954-1 doi (NATIONALLICENCE)springer-10.1007/s00405-014-2954-1 Expression of hypoxic signaling markers in head and neck squamous cell carcinoma and its clinical significance [Elektronische Daten] [Hyo Choi, Jin-Soo Kim, Ki Kim, Kwang Kim, Myung-Whun Sung, Ji-Young Choe, Ji Kim, Young Jung] Hypoxia is a consistent finding in fast-growing tumors; it contributes to tumor progression and therapeutic responses. We explored the expression of hypoxia-associated biomarkers in head and neck squamous cell carcinoma (HNSCC) to assess their relationship with clinical factors in HNSCC. In total, 90 patients with HNSCC were enrolled. Expression of HIF-1α, HSP70, HSP90, VEGF, IGF-1R, and P16 was investigated by immunohistochemistry. Their correlations with clinical factors, including location of primary sites, T stage, N stage, M stage, HPV status, primary treatment success/failure, recurrences, disease-free survival (DFS), and overall survival, were analyzed. HIF-1α, HPS70, HPS90, VEGF, and IGF-1R were positive in 33 of 89 (37.1%), 62 of 87 (71.3%), 83 of 89 (93.3%), 41 of 87 (47.1%), and 50 of 56 (89.3%) cases, respectively. Expression levels of some of these markers were correlated. High HIF-1α or HSP 70 correlated with poor DFS, and expression of HSP70 correlated with LN metastasis. HPV-related carcinomas showed high HSP 70 and IGF-1R expression. Hypoxia-associated proteins were highly expressed and associated with aggressive clinical features in HNSCC. Expression of HIF-1α or HSP70 can be considered poor prognostic indicator in HNSCC. Our results suggest that hypoxic signaling is activated in HNSCC, especially in HPV-related tumors. Springer-Verlag Berlin Heidelberg, 2014 Hypoxia-inducible factor 1 nationallicence Alpha subunit nationallicence HSP70 heat-shock proteins nationallicence HSP90 heat-shock proteins nationallicence Vascular endothelial growth factor A nationallicence Receptor nationallicence IGF Type 1 nationallicence Tumor markers nationallicence Biological nationallicence Choi Hyo Department of Otorhinolaryngology-Head and Neck Surgery, Hallym University Sacred Heart Hospital, Anyang, Korea aut Kim Jin-Soo Department of Internal Medicine, Seoul National University Boramae Hospital, Seoul, Korea aut Kim Ki Department of Internal Medicine, Seoul National University Boramae Hospital, Seoul, Korea aut Kim Kwang Department of Otorhinolaryngology-Head and Neck Surgery, Seoul National University Boramae Hospital, Seoul National University College of Medicine, 39, Boramae-Gil, Dongjak-Gu, 156-707, Seoul, Korea aut Sung Myung-Whun Department of Otorhinolaryngology-Head and Neck Surgery, Seoul National University Hospital, Seoul, Korea aut Choe Ji-Young Department of Pathology, Seoul National University Boramae Hospital, Seoul National University College of Medicine, 39, Boramae-Gil, Dongjak-Gu, 156-707, Seoul, Korea aut Kim Ji Department of Pathology, Seoul National University Boramae Hospital, Seoul National University College of Medicine, 39, Boramae-Gil, Dongjak-Gu, 156-707, Seoul, Korea aut Jung Young Department of Otorhinolaryngology-Head and Neck Surgery, Seoul National University Boramae Hospital, Seoul National University College of Medicine, 39, Boramae-Gil, Dongjak-Gu, 156-707, Seoul, Korea aut European Archives of Oto-Rhino-Laryngology Springer Berlin Heidelberg 272/1(2015-01-01), 219-228 0937-4477 272:1<219 2015 272 405 https://doi.org/10.1007/s00405-014-2954-1 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00405-014-2954-1 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Choi Hyo Department of Otorhinolaryngology-Head and Neck Surgery, Hallym University Sacred Heart Hospital, Anyang, Korea aut NATIONALLICENCE 700 1- Kim Jin-Soo Department of Internal Medicine, Seoul National University Boramae Hospital, Seoul, Korea aut NATIONALLICENCE 700 1- Kim Ki Department of Internal Medicine, Seoul National University Boramae Hospital, Seoul, Korea aut NATIONALLICENCE 700 1- Kim Kwang Department of Otorhinolaryngology-Head and Neck Surgery, Seoul National University Boramae Hospital, Seoul National University College of Medicine, 39, Boramae-Gil, Dongjak-Gu, 156-707, Seoul, Korea aut NATIONALLICENCE 700 1- Sung Myung-Whun Department of Otorhinolaryngology-Head and Neck Surgery, Seoul National University Hospital, Seoul, Korea aut NATIONALLICENCE 700 1- Choe Ji-Young Department of Pathology, Seoul National University Boramae Hospital, Seoul National University College of Medicine, 39, Boramae-Gil, Dongjak-Gu, 156-707, Seoul, Korea aut NATIONALLICENCE 700 1- Kim Ji Department of Pathology, Seoul National University Boramae Hospital, Seoul National University College of Medicine, 39, Boramae-Gil, Dongjak-Gu, 156-707, Seoul, Korea aut NATIONALLICENCE 700 1- Jung Young Department of Otorhinolaryngology-Head and Neck Surgery, Seoul National University Boramae Hospital, Seoul National University College of Medicine, 39, Boramae-Gil, Dongjak-Gu, 156-707, Seoul, Korea aut NATIONALLICENCE 773 0- European Archives of Oto-Rhino-Laryngology Springer Berlin Heidelberg 272/1(2015-01-01), 219-228 0937-4477 272:1<219 2015 272 405