caa a22 4500 606182500 CHVBK 20210128100816.0 cr unu---uuuuu 210128e20150101xx s 000 0 eng 10.1007/s00405-014-2987-5 doi (NATIONALLICENCE)springer-10.1007/s00405-014-2987-5 Analysis of acute impact of oleoresin capsicum on rat nasal mucosa using scanning electron microscopy [Elektronische Daten] [Tolgahan Catli, Mustafa Acar, Yüksel Olgun, İlknur Dağ, Betül Cengiz, Cemal Cingi] Analysis of acute cellular changes seen in nasal mucosa of Wistar-Albino rats exposed to different doses of oleoresin capsicum for various time periods by means of scanning electron microscopy. Thirty-five Wistar-Albino rats were divided into five groups of seven rats each. 6-gram oleoresin capsicum per second was sprayed into cages of the groups except group 1. Spray times and duration of exposure to pepper gasses were different for each group. Thirty minutes after the exposure, the animals were killed and specimens from their nasal mucosas were harvested and examined under scanning electron microscope. Mucosal damage was scored from 0-4 points. Mean values of nasal mucosa damage scores of the groups were calculated and compared statistically. Average damage scores of the groups exposed to identical doses of oleoresin capsicum for various exposure times were compared and a statistically significant difference was seen between Groups 2 and 3 (p<0.05), however the difference between Groups 4 and 5 was insignificant (p>0.05). Average damage scores of the groups exposed to various doses for identical exposure times were compared, and statistically significant differences were observed between Groups 2 and 4 and also Groups 3 and 5 (p<0.05). Outcomes of our study have demonstrated that pepper gas exerts destructive changes on rat nasal mucosa. The extent of these destructive changes increases with the prolonged exposure to higher doses. Besides, exposure time also stands out as an influential factor on the extent of the destructive changes. Springer-Verlag Berlin Heidelberg, 2014 Pepper spray nationallicence Capsaicin nationallicence Electron microscopy nationallicence Catli Tolgahan Department of Otorhinolaryngology, Bozyaka Teaching and Research Hospital, 35170, Izmir, Turkey aut Acar Mustafa Department of Otorhinolaryngology, Yunus Emre State Hospital, Eskisehir, Turkey aut Olgun Yüksel Department of Otorhinolaryngology, Bozyaka Teaching and Research Hospital, 35170, Izmir, Turkey aut Dağ İlknur Department of Electron Microscopy, Osmangazi University Medical Faculty, Eskisehir, Turkey aut Cengiz Betül Department of Pathology, Yunus Emre State Hospital, Eskisehir, Turkey aut Cingi Cemal Department of Otorhinolaryngology, Osmangazi University Medical Faculty, Eskisehir, Turkey aut European Archives of Oto-Rhino-Laryngology Springer Berlin Heidelberg 272/1(2015-01-01), 9-13 0937-4477 272:1<9 2015 272 405 https://doi.org/10.1007/s00405-014-2987-5 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 review-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00405-014-2987-5 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Catli Tolgahan Department of Otorhinolaryngology, Bozyaka Teaching and Research Hospital, 35170, Izmir, Turkey aut NATIONALLICENCE 700 1- Acar Mustafa Department of Otorhinolaryngology, Yunus Emre State Hospital, Eskisehir, Turkey aut NATIONALLICENCE 700 1- Olgun Yüksel Department of Otorhinolaryngology, Bozyaka Teaching and Research Hospital, 35170, Izmir, Turkey aut NATIONALLICENCE 700 1- Dağ İlknur Department of Electron Microscopy, Osmangazi University Medical Faculty, Eskisehir, Turkey aut NATIONALLICENCE 700 1- Cengiz Betül Department of Pathology, Yunus Emre State Hospital, Eskisehir, Turkey aut NATIONALLICENCE 700 1- Cingi Cemal Department of Otorhinolaryngology, Osmangazi University Medical Faculty, Eskisehir, Turkey aut NATIONALLICENCE 773 0- European Archives of Oto-Rhino-Laryngology Springer Berlin Heidelberg 272/1(2015-01-01), 9-13 0937-4477 272:1<9 2015 272 405