caa a22 4500 606182837 CHVBK 20210128100818.0 cr unu---uuuuu 210128e20150601xx s 000 0 eng 10.1007/s00405-014-3434-3 doi (NATIONALLICENCE)springer-10.1007/s00405-014-3434-3 Effect of antibiotic use on bacterial flora of tonsil core in patients with recurrent tonsillitis [Elektronische Daten] [Uzeyir Yildizoglu, Bahtiyar Polat, Ramazan Gumral, Abdullah Kilic, Fuat Tosun, Mustafa Gerek] The aim of this study was to investigate the effects of commonly used antibiotics on bacterial flora of the tonsil core. Patients who underwent tonsillectomy for recurrent chronic tonsillitis were included in the study. Three groups were formed: group 1 was treated for 10days preoperatively with amoxicillin/clavulanic acid; group 2 was treated for 10days preoperatively with clarithromycin; and group 3 included patients who underwent tonsillectomy without preoperative antibiotic use. The removed palatine tonsils were sent to our microbiology department in sterile tubes for bacteriological analysis. Seventy-three patients (group 1=19, group 2=20, group 3=34 patients) aged 3-18years (mean 7years) were included in the study. At least one bacterium was isolated from all tonsils, except for two cases in group 1; the difference in single bacterial growth among groups was not significant (p=0.06). On the other hand, the numbers of patients with pathogenic bacterial growth was significantly lower in group 2 (n=2) compared with group 1 (n=10) and group 3 (n=27) (p<0.001). The bacterium isolated most frequently from the tonsils was Streptococcus viridans. Pseudomonas aeruginosa was the only pathogenic bacterium that grew in all three groups. Clarithromycin was more effective than amoxicillin/clavulanic acid in eradicating pathogenic bacteria in the tonsil core. Pseudomonas aeruginosa might be responsible for resistant or recurrent tonsil infections. To prevent endocarditis, antibiotic prophylaxis toward S. viridians, which is the most prevalent bacterium in the tonsil core, should be kept in mind for patients with heart valve damage. Springer-Verlag Berlin Heidelberg, 2014 Chronic tonsillitis nationallicence Tonsillectomy nationallicence Tonsil core nationallicence Bacterial flora nationallicence Antibiotic usage nationallicence Yildizoglu Uzeyir Department of Otorhinolaryngology Head and Neck Surgery, Beytepe Military Hospital, 06800, Cankaya, Ankara, Turkey aut Polat Bahtiyar Department of Otorhinolaryngology Head and Neck Surgery, Gelibolu Military Hospital, 17500, Gelibolu, Ankara, Turkey aut Gumral Ramazan Department of Microbiology, Gulhane Military Medical Academy, 06018, Etlik, Ankara, Turkey aut Kilic Abdullah Department of Microbiology, Gulhane Military Medical Academy, 06018, Etlik, Ankara, Turkey aut Tosun Fuat Department of Otorhinolaryngology Head and Neck Surgery, Gulhane Military Medical Academy, 06018, Etlik, Ankara, Turkey aut Gerek Mustafa Department of Otorhinolaryngology Head and Neck Surgery, Gulhane Military Medical Academy, 06018, Etlik, Ankara, Turkey aut European Archives of Oto-Rhino-Laryngology Springer Berlin Heidelberg 272/6(2015-06-01), 1525-1528 0937-4477 272:6<1525 2015 272 405 https://doi.org/10.1007/s00405-014-3434-3 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00405-014-3434-3 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Yildizoglu Uzeyir Department of Otorhinolaryngology Head and Neck Surgery, Beytepe Military Hospital, 06800, Cankaya, Ankara, Turkey aut NATIONALLICENCE 700 1- Polat Bahtiyar Department of Otorhinolaryngology Head and Neck Surgery, Gelibolu Military Hospital, 17500, Gelibolu, Ankara, Turkey aut NATIONALLICENCE 700 1- Gumral Ramazan Department of Microbiology, Gulhane Military Medical Academy, 06018, Etlik, Ankara, Turkey aut NATIONALLICENCE 700 1- Kilic Abdullah Department of Microbiology, Gulhane Military Medical Academy, 06018, Etlik, Ankara, Turkey aut NATIONALLICENCE 700 1- Tosun Fuat Department of Otorhinolaryngology Head and Neck Surgery, Gulhane Military Medical Academy, 06018, Etlik, Ankara, Turkey aut NATIONALLICENCE 700 1- Gerek Mustafa Department of Otorhinolaryngology Head and Neck Surgery, Gulhane Military Medical Academy, 06018, Etlik, Ankara, Turkey aut NATIONALLICENCE 773 0- European Archives of Oto-Rhino-Laryngology Springer Berlin Heidelberg 272/6(2015-06-01), 1525-1528 0937-4477 272:6<1525 2015 272 405