caa a22 4500 606182888 CHVBK 20210128100818.0 cr unu---uuuuu 210128e20150601xx s 000 0 eng 10.1007/s00405-014-2947-0 doi (NATIONALLICENCE)springer-10.1007/s00405-014-2947-0 Chemical labyrinthectomy for the worse ear of adult Nigerians with bilateral Meniere's disease: preliminary report of treatment outcomes [Elektronische Daten] [A. Olusesi, S. Hassan, Y. Oyeyipo, U. Ukwuije, O. Oyeniran] The objective of this study was to assess the effectiveness of variable titration, low-dose intratympanic gentamycin (ITG) into the worse affected ear of patients with bilateral Meniere's disease (MD). It is a prospective analytic case series conducted in a tertiary care referral hospital in a developing economy and a tertiary care otologic private ENT clinic. Patients with MD who failed or are intolerant to medical treatment were recruited based on the criteria of definite MD and bilateral ear involvement. 0.75cc of low-dose (40mg/ml) buffered gentamycin was injected into the worse affected ear and patients followed up every 2months, and the regime repeated only if subjective vertigo persists. The patient's age, sex, duration of MD symptom, ear first affected, ear selected for ITG, pure tone threshold at each visit, duration of caloric response (in seconds) for the injected ear, status of tinnitus in both ipsilateral (injected) and contralateral ears, total number of injections before last follow-up, and time since last follow-up are entered into the study protocol and analyzed. Nine patients with a mean age of 45years and mean duration of symptoms of 59months were treated. The mean total number of injections was 2.8 with a mean follow-up period of 34months. Three cases showed drop in pure tone average threshold (2.5-7.5dB) while an increase in threshold was noted in six cases (2.5-5dB). All cases demonstrated decrease in duration of response to iced water caloric stimulation in ipsilateral ear, and 4/9 of contralateral ear. The variable titration method using low-dose intratympanic gentamycin directed at worse ear of adult Nigerians with bilateral Meniere's disease appears to be highly effective. More studies are needed. Springer-Verlag Berlin Heidelberg, 2014 Chemical labyrinthectomy nationallicence Transtympanic gentamycin nationallicence Meniere's disease nationallicence Nigeria nationallicence Africa nationallicence Olusesi A. Department of Ear, Nose and Throat, National Hospital Abuja, Plot 132, Central Area, Garki (Phase 2), 900001, Abuja, FCT, Nigeria aut Hassan S. Department of Ear, Nose and Throat, National Hospital Abuja, Plot 132, Central Area, Garki (Phase 2), 900001, Abuja, FCT, Nigeria aut Oyeyipo Y. Department of Ear, Nose and Throat, National Hospital Abuja, Plot 132, Central Area, Garki (Phase 2), 900001, Abuja, FCT, Nigeria aut Ukwuije U. Department of Ear, Nose and Throat, National Hospital Abuja, Plot 132, Central Area, Garki (Phase 2), 900001, Abuja, FCT, Nigeria aut Oyeniran O. Department of Ear, Nose and Throat, National Hospital Abuja, Plot 132, Central Area, Garki (Phase 2), 900001, Abuja, FCT, Nigeria aut European Archives of Oto-Rhino-Laryngology Springer Berlin Heidelberg 272/6(2015-06-01), 1383-1387 0937-4477 272:6<1383 2015 272 405 https://doi.org/10.1007/s00405-014-2947-0 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00405-014-2947-0 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Olusesi A. Department of Ear, Nose and Throat, National Hospital Abuja, Plot 132, Central Area, Garki (Phase 2), 900001, Abuja, FCT, Nigeria aut NATIONALLICENCE 700 1- Hassan S. Department of Ear, Nose and Throat, National Hospital Abuja, Plot 132, Central Area, Garki (Phase 2), 900001, Abuja, FCT, Nigeria aut NATIONALLICENCE 700 1- Oyeyipo Y. Department of Ear, Nose and Throat, National Hospital Abuja, Plot 132, Central Area, Garki (Phase 2), 900001, Abuja, FCT, Nigeria aut NATIONALLICENCE 700 1- Ukwuije U. Department of Ear, Nose and Throat, National Hospital Abuja, Plot 132, Central Area, Garki (Phase 2), 900001, Abuja, FCT, Nigeria aut NATIONALLICENCE 700 1- Oyeniran O. Department of Ear, Nose and Throat, National Hospital Abuja, Plot 132, Central Area, Garki (Phase 2), 900001, Abuja, FCT, Nigeria aut NATIONALLICENCE 773 0- European Archives of Oto-Rhino-Laryngology Springer Berlin Heidelberg 272/6(2015-06-01), 1383-1387 0937-4477 272:6<1383 2015 272 405