caa a22 4500 606182977 CHVBK 20210128100819.0 cr unu---uuuuu 210128e20150601xx s 000 0 eng 10.1007/s00405-014-2942-5 doi (NATIONALLICENCE)springer-10.1007/s00405-014-2942-5 Preliminary results of a novel quorum sensing inhibitor against pneumococcal infection and biofilm formation with special interest to otitis media and cochlear implantation [Elektronische Daten] [Raşit Cevizci, Mehmet Düzlü, Yasemin Dündar, Ningur Noyanalpan, Nedim Sultan, Hakan Tutar, Yıldırım Bayazıt] The purpose of the study is to assess the effect of a novel quorum sensing inhibitor (QSI), coded as ‘yd 47', against otitis media and biofilm formation on Cochlear implants (CIs). Small pieces cut from cochlear implant were implanted under the skin in the retroauricular area on both sides of four guinea pigs. The implant pieces in the study and control sides were implanted in Streptococcus pneumoniae strain solution and saline, respectively. The right and left middle ears were also instilled with a solution containing pneumococci and saline, respectively. The animals were only given an intraperitoneal ‘yd 47' twice daily for three months to be assessed later with electron microscopy. Clinical examination with palpation, inspection and otoscopy did not reveal any sign of implant infection or otitis media. In the study and control implant materials, soft tissues around the implant and tympanic membranes, there was no biofilm formation by pneumococci. Contamination by various cells and some rod-shaped bacteria (not diplococcic) were seen in some of the materials. In conclusion, the novel QSI seems promising in the prevention of otitis media and biofilm formation on CIs by pneumococci. Springer-Verlag Berlin Heidelberg, 2014 Biofilm nationallicence Quorum sensing nationallicence Cochlear implant infection nationallicence Cevizci Raşit Otorhinolaryngology Department, Medipol University Faculty of Medicine, Bağcılar, 34200, Istanbul, Turkey aut Düzlü Mehmet Otorhinolaryngology Department, Gazi University Faculty of Medicine, Ankara, Turkey aut Dündar Yasemin Gazi University Faculty of Pharmacy, Ankara, Turkey aut Noyanalpan Ningur Gazi University Faculty of Pharmacy, Ankara, Turkey aut Sultan Nedim Microbiology Department, Gazi University Faculty of Medicine, Ankara, Turkey aut Tutar Hakan Otorhinolaryngology Department, Gazi University Faculty of Medicine, Ankara, Turkey aut Bayazıt Yıldırım Otorhinolaryngology Department, Medipol University Faculty of Medicine, Bağcılar, 34200, Istanbul, Turkey aut European Archives of Oto-Rhino-Laryngology Springer Berlin Heidelberg 272/6(2015-06-01), 1389-1393 0937-4477 272:6<1389 2015 272 405 https://doi.org/10.1007/s00405-014-2942-5 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00405-014-2942-5 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Cevizci Raşit Otorhinolaryngology Department, Medipol University Faculty of Medicine, Bağcılar, 34200, Istanbul, Turkey aut NATIONALLICENCE 700 1- Düzlü Mehmet Otorhinolaryngology Department, Gazi University Faculty of Medicine, Ankara, Turkey aut NATIONALLICENCE 700 1- Dündar Yasemin Gazi University Faculty of Pharmacy, Ankara, Turkey aut NATIONALLICENCE 700 1- Noyanalpan Ningur Gazi University Faculty of Pharmacy, Ankara, Turkey aut NATIONALLICENCE 700 1- Sultan Nedim Microbiology Department, Gazi University Faculty of Medicine, Ankara, Turkey aut NATIONALLICENCE 700 1- Tutar Hakan Otorhinolaryngology Department, Gazi University Faculty of Medicine, Ankara, Turkey aut NATIONALLICENCE 700 1- Bayazıt Yıldırım Otorhinolaryngology Department, Medipol University Faculty of Medicine, Bağcılar, 34200, Istanbul, Turkey aut NATIONALLICENCE 773 0- European Archives of Oto-Rhino-Laryngology Springer Berlin Heidelberg 272/6(2015-06-01), 1389-1393 0937-4477 272:6<1389 2015 272 405